HAMAP rule MF_02101

General rule information [?]

Accession	MF_02101
Dates	15-MAY-2009 (Created) 17-FEB-2023 (Last updated, Version 12)
Name	DHNA_CoA_hydrolase
Scope(s)	Bacteria Cyanobacteriota
Template(s)	Q55777 (DNCH_SYNY3); [ Recover all ]
Triggered by	HAMAP; MF_02101 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DNCH
Protein name	RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase; Short=DHNA-CoA hydrolase; EC=3.1.2.28; AltName: Full=DHNA-CoA thioesterase;

Comments [?]

FUNCTION	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
CATALYTIC ACTIVITY	Reaction=1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2- naphthoate + CoA + H(+); Xref=Rhea:RHEA:26309, ChEBI:CHEBI:11173, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58897; EC=3.1.2.28;
PATHWAY	Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
PATHWAY	Cofactor biosynthesis; phylloquinone biosynthesis.
SIMILARITY	Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function:thiolester hydrolase activity

GO:0042372; Biological process:phylloquinone biosynthetic process

Cross-references [?]

PROSITE	PS01328; 4HBCOA_THIOESTERASE; 1;
Pfam	PF03061; 4HBT; 1;

Features [?]

From: DNCH_SYNY3 (Q55777)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

Additional information [?]