HAMAP rule MF_03138

General rule information [?]

Accession	MF_03138
Dates	2-NOV-2010 (Created) 1-JUN-2023 (Last updated, Version 11)
Name	GUFP
Scope(s)	Eukaryota Viridiplantae Plastid
Template(s)	Q9FNM5 (GUFP_ARATH); [ Recover all ]
Triggered by	case c? <OC:Eukaryota> or <OG:Plastid> HAMAP; MF_03138 (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GUFP
case <OG:Organellar chromatophore>
RecName: Full=Translation factor GUF1 homolog, organellar chromatophore;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.5.n1">3.6.5.n1</a>;<br /> AltName: Full=Elongation factor 4 homolog;<br />                  Short=EF-4;<br /> AltName: Full=GTPase GUF1 homolog;<br /> AltName: Full=Ribosomal back-translocase;
else
RecName: Full=Translation factor GUF1 homolog, chloroplastic;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.5.n1">3.6.5.n1</a>;<br /> AltName: Full=Elongation factor 4 homolog;<br />                  Short=EF-4;<br /> AltName: Full=GTPase GUF1 homolog;<br /> AltName: Full=Ribosomal back-translocase;
end case
case <OG:Organellar chromatophore>
Gene name	Name=lepA;
end case

Comments [?]

case <OG:Organellar chromatophore>
FUNCTION	Promotes protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.
else
FUNCTION	Promotes chloroplast protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.
end case
CATALYTIC ACTIVITY	Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.n1;
case <OG:Organellar chromatophore>
SUBCELLULAR LOCATION	Plastid, organellar chromatophore.
else
SUBCELLULAR LOCATION	Plastid, chloroplast.
end case
case not <OG:Organellar chromatophore> and not <AnyFeature:TransitC>
MISCELLANEOUS	This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITY	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.

Keywords [?]

case <OG:Organellar chromatophore>
Organellar chromatophore
else
Chloroplast
end case
Plastid
GTP-binding
Hydrolase
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

case <OG:Organellar chromatophore>
GO:0070111; Cellular component:organellar chromatophore
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0009507; Cellular component:chloroplast
end case
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
GO:0045727; Biological process:positive regulation of translation

Cross-references [?]

Features [?]

From: GUFP_ARATH (Q9FNM5)

Key

From

Description

Tag

Condition

FTGroup

BINDING

100

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

[AS]-H-[IV]-D-[HS]-G-K-[ST]

BINDING

158

162

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

D-T-[CP]-G-H

BINDING

212

215

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

[NT]-K-[IMV]-D

Additional information [?]