HAMAP rule MF_03227
General rule information
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| Accession | MF_03227 |
| Dates | 17-JUN-2019 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | But_acet_CoA_trans |
| Scope(s) |
Bacteria |
| Template(s) | G2SYC0 (BCACT_ROSHA); B0MC58 (BCACT_ANACD); [ Recover all ] |
| Triggered by |
HAMAP; MF_03227 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | BCACT |
| Protein name | RecName: Full=Butyryl-CoA:acetate CoA-transferase; Short=Butyryl-CoA CoA-transferase; EC=2.8.3.-; |
Comments
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| FUNCTION | Coenzyme A-transferase that converts butyryl-CoA to butyrate. |
| CATALYTIC ACTIVITY | Reaction=acetyl-CoA + butanoate = acetate + butanoyl-CoA; Xref=Rhea:RHEA:30071, ChEBI:CHEBI:17968, ChEBI:CHEBI:30089, ChEBI:CHEBI:57288, ChEBI:CHEBI:57371; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:30073; |
| PATHWAY | Lipid metabolism; butanoate metabolism. |
| SIMILARITY | Belongs to the acetyl-CoA hydrolase/transferase family. Butyryl-CoA CoA-transferase subfamily. |
Keywords
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Gene Ontology
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| GO:0016740; Molecular function:transferase activity |
| GO:0006084; Biological process:acetyl-CoA metabolic process |
| GO:0046358; Biological process:butyrate biosynthetic process |
Cross-references
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| Pfam | PF13336; AcetylCoA_hyd_C; 1; |
| Pfam | PF02550; AcetylCoA_hydro; 1; |
| NCBIfam | TIGR03948; butyr_acet_CoA; 1; |
Features
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| From: BCACT_ROSHA (G2SYC0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 220 | 224 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
G-x-G-x-M | ||||||||
| ACT_SITE | 245 | 245 | /note="5-glutamyl coenzyme A thioester intermediate" | E | ||||||||
| BINDING | 320 | 320 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
[ILVM] | ||||||||
| BINDING | 343 | 343 | /ligand="CoA" /ligand_id="ChEBI:CHEBI:57287" |
G | ||||||||
Additional information
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| Size range | 443-453 amino acids |
| Related rules |
MF_03228 |
| Fusion | Nter: None Cter: None |
| Comments | The fermentation acid butyrate is of special interest, as it has been shown to serve as the preferred energy source for the gut wall and also influences cell differentiation and apoptosis in the colon, and this seems to aid in protection against colon cancer and inflammatory bowel disease. Formation of butyrate via butyryl-CoA CoA-transferase is the only available route for butyrate synthesis in the majority of human gut isolates. |