HAMAP rule MF_00049
General rule information
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| Accession | MF_00049 |
| Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 36) |
| Name | Leu_tRNA_synth |
| Scope | Bacteria
Archaea |
| Template | P07813 (SYL_ECOLI) |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Catalytic activity | RHEA:11688: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
EC 6.1.1.4 |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the class-I aminoacyl-tRNA synthetase family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0004823; Molecular function: leucine-tRNA ligase activity.
GO:0006429; Biological process: leucyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0004823; Molecular function: leucine-tRNA ligase activity.
GO:0006429; Biological process: leucyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00133; tRNA-synt_1; 1; |
| PRINTS | PR00985; TRNASYNTHLEU; 1; |
| NCBIfam | TIGR00395; LeuS_arch; 1; |
| TIGR00396; LeuS_bact; 1; | |
| PROSITE | PS00178; AA_TRNA_LIGASE_I; 1; |
Features
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case <OC:Bacteria>
| From: SYL_ECOLI (P07813) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 42 | 52 | 'HIGH' region | [SP]-[YF]-[PLVT]-[SN]-[GAS]-x(1,3)-H-[LIVMA]-G-[HS] | ||||||||
| MOTIF | 619 | 623 | 'KMSKS' region | [KRTA]-[MLI]-[SGA]-[KS]-[SA] | ||||||||
| BINDING | 622 | 622 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K | ||||||||
end case
case <OC:Archaea>
| From: SYL_METJA (Q58050) | ||||||||||||
| MOTIF | 41 | 51 | 'HIGH' region | P-Y-x-[SN]-[GAS]-x(2)-H-[LIVMA]-G-[HS] | ||||||||
| MOTIF | 633 | 637 | 'KMSKS' region | |||||||||
| BINDING | 636 | 636 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K | ||||||||
end case
Additional information
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case <OC:Bacteria>
| Size range | 792-990 amino acids |
end case
case <OC:Archaea>
| Size range | 910-977 amino acids |
end case
| Related rules | None |
| Fusion | None |
| Comments | The AQUAE leuS is cut into two subunits. It is not shown in the alignment. There is a shorter second copy in SULTO, which is not shown in the alignment, nor are HALSA or NANEQ as they are quite divergent. |