HAMAP rule MF_00049
General rule information
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Accession | MF_00049 |
Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 35) |
Name | Leu_tRNA_synth |
Scope | Bacteria
Archaea |
Template | P07813 (SYL_ECOLI) |
case <OC:Bacteria>
Triggered by |
end case
case <OC:Archaea>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Catalytic activity | RHEA:11688: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
EC 6.1.1.4 |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class-I aminoacyl-tRNA synthetase family. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0004823; Molecular function: leucine-tRNA ligase activity.
GO:0006429; Biological process: leucyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0004823; Molecular function: leucine-tRNA ligase activity.
GO:0006429; Biological process: leucyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00133; tRNA-synt_1; 1; |
PRINTS | PR00985; TRNASYNTHLEU; 1; |
TIGRFAMs | TIGR00395; LeuS_arch; 1; |
TIGR00396; LeuS_bact; 1; | |
PROSITE | PS00178; AA_TRNA_LIGASE_I; 1; |
Features
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case <OC:Bacteria>
From: SYL_ECOLI (P07813) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 42 | 52 | 'HIGH' region | [SP]-[YF]-[PLVT]-[SN]-[GAS]-x(1,3)-H-[LIVMA]-G-[HS] | ||||||||
MOTIF | 619 | 623 | 'KMSKS' region | [KRTA]-[MLI]-[SGA]-[KS]-[SA] | ||||||||
BINDING | 622 | 622 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K |
end case
case <OC:Archaea>
From: SYL_METJA (Q58050) | ||||||||||||
MOTIF | 41 | 51 | 'HIGH' region | P-Y-x-[SN]-[GAS]-x(2)-H-[LIVMA]-G-[HS] | ||||||||
MOTIF | 633 | 637 | 'KMSKS' region | |||||||||
BINDING | 636 | 636 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K |
end case
Additional information
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case <OC:Bacteria>
Size range | 792-990 amino acids |
end case
case <OC:Archaea>
Size range | 910-977 amino acids |
end case
Related rules | None |
Fusion | None |
Comments | The AQUAE leuS is cut into two subunits. It is not shown in the alignment. There is a shorter second copy in SULTO, which is not shown in the alignment, nor are HALSA or NANEQ as they are quite divergent. |