HAMAP rule MF_00076
General rule information
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| Accession | MF_00076 |
| Dates | 14-JUN-2002 (Created)
28-JUN-2024 (Last updated, Version 34) |
| Name | HisB |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q02134 (HIS7_LACLA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00076 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HIS7 |
| Protein name | RecName: Full=Imidazoleglycerol-phosphate dehydratase; Short=IGPD; EC=4.2.1.19; |
| Gene name | Name=hisB; |
Comments
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| CATALYTIC ACTIVITY | Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol- 4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040, ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19; |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the imidazoleglycerol-phosphate dehydratase family. |
Keywords
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Gene Ontology
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| GO:0004424; Molecular function:imidazoleglycerol-phosphate dehydratase activity |
| GO:0000105; Biological process:L-histidine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00475; IGPD; 1; |
| PROSITE | PS00954; IGP_DEHYDRATASE_1; 1; |
| PROSITE | PS00955; IGP_DEHYDRATASE_2; 1; |
Features
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Additional information
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| Size range | 176-216 amino acids |
| Related rules |
MF_01022 |
| Fusion | Nter: None Cter: None |
| Comments | Longer N-terminal in NEIMA and NEIMB; not shown in alignment and not taken into account in size range. See MF_01022 for bifunctional hisB. |