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HAMAP rule MF_00076

General rule information [?]

Accession	MF_00076
Dates	14-JUN-2002 (Created) 28-JUN-2024 (Last updated, Version 34)
Name	HisB
Scope(s)	Bacteria Archaea
Template(s)	Q02134 (HIS7_LACLA); [ Recover all ]
Triggered by	HAMAP; MF_00076 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HIS7
Protein name	RecName: Full=Imidazoleglycerol-phosphate dehydratase; Short=IGPD; EC=4.2.1.19;
Gene name	Name=hisB;

Comments [?]

CATALYTIC ACTIVITY	Reaction=D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol- 4-yl)-2-oxopropyl phosphate + H2O; Xref=Rhea:RHEA:11040, ChEBI:CHEBI:15377, ChEBI:CHEBI:57766, ChEBI:CHEBI:58278; EC=4.2.1.19;
PATHWAY	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the imidazoleglycerol-phosphate dehydratase family.

Keywords [?]

Gene Ontology [?]

GO:0004424; Molecular function:imidazoleglycerol-phosphate dehydratase activity

GO:0000105; Biological process:L-histidine biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]

Size range	176-216 amino acids
Related rules	MF_01022
Fusion	Nter: None Cter: None
Comments	Longer N-terminal in NEIMA and NEIMB; not shown in alignment and not taken into account in size range. See MF_01022 for bifunctional hisB.