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Annotation rule MF_00076
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General rule information [?]

Accession MF_00076
Dates 14-JUN-2002 (Created)
20-NOV-2019 (Last updated, Version 33)
Name HisB
Scope
Bacteria
Archaea
Template Q02134 (HIS7_LACLA)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HIS7
Protein name
RecName: Full=Imidazoleglycerol-phosphate dehydratase;
Short=IGPD;
EC 4.2.1.19;
Gene name
hisB

Comments [?]

Catalytic activity RHEA:11040: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
EC 4.2.1.19
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
Subcellular location Cytoplasm.
Similarity Belongs to the imidazoleglycerol-phosphate dehydratase family.

Keywords [?]


Gene Ontology [?]

GO:0004424; Molecular function: imidazoleglycerol-phosphate dehydratase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00475; IGPD; 1;
PROSITE PS00954; IGP_DEHYDRATASE_1; 1;
PS00955; IGP_DEHYDRATASE_2; 1;

Additional information [?]

Size range 176-216 amino acids
Related rules MF_01022 (HIS7 supersedes the current rule)
Fusion None
Comments Longer N-terminal in NEIMA and NEIMB; not shown in alignment and not taken into account in size range. See MF_01022 for bifunctional hisB.