HAMAP rule MF_00076

General rule information [?]

Accession	MF_00076
Dates	14-JUN-2002 (Created) 20-NOV-2019 (Last updated, Version 33)

Name

HisB

Scope

Bacteria

Archaea

Template

Q02134 (HIS7_LACLA)

Triggered by

HAMAP; MF_00076 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HIS7

Protein name

RecName:		Full=Imidazoleglycerol-phosphate dehydratase;
		Short=IGPD;
		EC 4.2.1.19;

Gene name

hisB

Comments [?]

Catalytic activity	RHEA:11040: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O EC 4.2.1.19
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
Subcellular location	Cytoplasm.
Similarity	Belongs to the imidazoleglycerol-phosphate dehydratase family.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Histidine biosynthesis
Lyase

Gene Ontology [?]

GO:0004424; Molecular function: imidazoleglycerol-phosphate dehydratase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00475; IGPD; 1;
PROSITE	PS00954; IGP_DEHYDRATASE_1; 1;
	PS00955; IGP_DEHYDRATASE_2; 1;

Additional information [?]

Size range	176-216 amino acids
Related rules	MF_01022 (HIS7 supersedes the current rule)
Fusion	None
Comments	Longer N-terminal in NEIMA and NEIMB; not shown in alignment and not taken into account in size range. See MF_01022 for bifunctional hisB.

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