HAMAP rule MF_00090
General rule information
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Accession | MF_00090 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32) |
Name | PIMT |
Scope(s) |
Bacteria Archaea |
Template(s) | Q56308 (PIMT_THEMA); Q8TZR3 (PIMT_PYRFU); [ Recover all ] |
Triggered by |
HAMAP; MF_00090 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PIMT |
Protein name | RecName: Full=Protein-L-isoaspartate O-methyltransferase; EC=2.1.1.77; AltName: Full=L-isoaspartyl protein carboxyl methyltransferase; AltName: Full=Protein L-isoaspartyl methyltransferase; AltName: Full=Protein-beta-aspartate methyltransferase; Short=PIMT; |
Gene name | Name=pcm; |
Comments
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FUNCTION | Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. |
CATALYTIC ACTIVITY | Reaction=[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:12705, Rhea:RHEA-COMP:12143, Rhea:RHEA- COMP:12144, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90596, ChEBI:CHEBI:90598; EC=2.1.1.77; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. |
Keywords
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Gene Ontology
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GO:0004719; Molecular function:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity |
GO:0036211; Biological process:protein modification process |
GO:0030091; Biological process:protein repair |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: PIMT_ECOLI (P0A7A5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 59 | 59 | S |
Additional information
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Size range | 198-327 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: <Unknown> |
Comments | Possible wrong starts. Unknown C-terminal domain in THEMA. |