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Annotation rule MF_00090
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General rule information [?]

Accession MF_00090
Dates 1-JUN-2001 (Created)
20-NOV-2019 (Last updated, Version 28)
Name PIMT
Scope
Bacteria
Archaea
Templates Q56308 (PIMT_THEMA); Q8TZR3 (PIMT_PYRFU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PIMT
Protein name
RecName: Full=Protein-L-isoaspartate O-methyltransferase;
EC 2.1.1.77;
AltName: Full=L-isoaspartyl protein carboxyl methyltransferase;
AltName: Full=Protein L-isoaspartyl methyltransferase;
AltName: Full=Protein-beta-aspartate methyltransferase;
Short=PIMT;
Gene name
pcm

Comments [?]

Function Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Catalytic activity RHEA:12705: [protein]-L-beta-isoaspartate + S-adenosyl-L-methionine = [protein]-L-beta-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine
EC 2.1.1.77
Subcellular location Cytoplasm.
Similarity Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

Keywords [?]


Gene Ontology [?]

GO:0004719; Molecular function: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity.
GO:0006464; Biological process: cellular protein modification process.
GO:0030091; Biological process: protein repair.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01135; PCMT; 1;
TIGRFAMs TIGR00080; Pimt; 1;
PROSITE PS01279; PCMT; 1;

Features [?]

From: PIMT_ECOLI (P0A7A5)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     59     59             S  

Additional information [?]

Size range 198-327 amino acids
Related rules None
Fusion Nter: None; Cter: <Unknown>
Comments Possible wrong starts. Unknown C-terminal domain in THEMA.