HAMAP rule MF_00090

Accession	MF_00090
Dates	1-JUN-2001 (Created) 3-MAY-2022 (Last updated, Version 31)

Name

PIMT

Scope

Bacteria Archaea

Templates

Q56308 (PIMT_THEMA); Q8TZR3 (PIMT_PYRFU): [Recover all]

Triggered by

HAMAP; MF_00090 (Get profile general information and statistics)

Identifier

PIMT

Protein name

RecName: Full=Protein-L-isoaspartate O-methyltransferase; EC 2.1.1.77; AltName: Full=L-isoaspartyl protein carboxyl methyltransferase; AltName: Full=Protein L-isoaspartyl methyltransferase; AltName: Full=Protein-beta-aspartate methyltransferase; Short=PIMT;

Gene name

pcm

Function	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Catalytic activity	RHEA:12705: [protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine EC 2.1.1.77
Subcellular location	Cytoplasm.
Similarity	Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

Cytoplasm
Transferase
Methyltransferase
S-adenosyl-L-methionine

GO:0004719; Molecular function: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity.
GO:0036211; Biological process: protein modification process.
GO:0030091; Biological process: protein repair.
GO:0005737; Cellular component: cytoplasm.

Pfam	PF01135; PCMT; 1;
TIGRFAMs	TIGR00080; Pimt; 1;
PROSITE	PS01279; PCMT; 1;

From: PIMT_ECOLI (P0A7A5)

Key

From

To

Description

Tag

Condition

FTGroup

ACT_SITE

59

59

S

Size range	198-327 amino acids
Related rules	None
Fusion	Nter: None; Cter: <Unknown>
Comments	Possible wrong starts. Unknown C-terminal domain in THEMA.

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