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Annotation rule MF_00100 |
General rule information
[?]
Accession |
MF_00100 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 50) |
Scope |
Bacteria
Archaea
Plastid |
case <OC:Bacteria> or <OG:Chloroplast>
end case
case <OC:Archaea>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Bacteria>
Protein name |
RecName:
|
Full=Translation initiation factor IF-2;
|
|
end case
case <OG:Chloroplast>
Protein name |
RecName:
|
Full=Translation initiation factor IF-2, chloroplastic;
|
|
end case
case <OC:Archaea>
Protein name |
RecName:
|
Full=Probable translation initiation factor IF-2;
|
|
end case
case <OC:Bacteria>
Function |
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. |
Subcellular location |
Cytoplasm. |
end case
case <OC:Archaea>
Function |
Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. |
end case
case <OG:Chloroplast>
Function |
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. |
Subcellular location |
Plastid, chloroplast. |
end case
Similarity |
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. |
case <OC:Bacteria>
end case
GO:0003924; Molecular function: GTPase activity.
GO:0003743; Molecular function: translation initiation factor activity.
GO:0006413; Biological process: translational initiation.
case <OC:Bacteria>
end case
case <OG:Chloroplast>
end case
case <OC:Bacteria> or <OG:Chloroplast>
From: IF2_ECOLI (P0A705) |
Key
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From
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|
To
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|
Description
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|
Tag
|
|
Condition
|
|
FTGroup
|
NP_BIND
|
|
398
|
|
405
|
|
GTP
|
|
|
|
G-H-V-D-H-G-K-T
|
|
|
NP_BIND
|
|
444
|
|
448
|
|
GTP
|
|
|
|
D-T-P-G-H
|
|
|
NP_BIND
|
|
498
|
|
501
|
|
GTP
|
|
|
|
[NST]-K-[LIVCMT]-D
|
|
|
REGION
|
|
392
|
|
540
|
|
G-domain
|
|
|
|
|
|
|
end case
case <OC:Archaea>
From: IF2P_METTH (O26359) |
NP_BIND
|
|
12
|
|
19
|
|
GTP
|
|
|
|
G-H-V-D-[HVA]-G-K-T
|
|
|
NP_BIND
|
|
76
|
|
80
|
|
GTP
|
|
|
|
D-T-P-G-H
|
|
|
NP_BIND
|
|
130
|
|
133
|
|
GTP
|
|
|
|
[NT]-K-[LIV]-D
|
|
|
end case
Additional information
[?]
case <OC:Bacteria>
Size range |
571-1183 amino acids |
end case
case <OC:Archaea>
Size range |
589-620 amino acids |
end case
Related rules |
None |
Fusion |
None |
Comments |
Intein in some members. |