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Annotation rule MF_00110 |
Accession | MF_00110 |
Dates | 1-JUN-2001 (Created) 31-MAY-2021 (Last updated, Version 42) |
Name | DHQ_synthase |
Scope | Bacteria
Archaea |
Templates | P07639 (AROB_ECOLI); Q6GGU4 (AROB_STAAR); P9WPX9 (AROB_MYCTU); P56081 (AROB_HELPY): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). |
Catalytic activity | RHEA:21968: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
EC 4.2.3.4 |
Cofactor | NAD(+) |
Co(2+) Zn(2+) Note: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+) |
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Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. |
Pfam | PF01761; DHQ_synthase; 1; |
TIGRFAMs | TIGR01357; aroB; 1; |
PIRSF | PIRSF001455; DHQ_synth; 1; |
From: AROB_MYCTU (P9WPX9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND (Optional) | 73 | 78 | NAD | [DES]-[GA]-E-x-x-K | ||||||||
NP_BIND (Optional) | 107 | 111 | NAD | G-[AV]-x-x-D | ||||||||
NP_BIND (Optional) | 131 | 132 | NAD | T-[TS] | ||||||||
NP_BIND (Optional) | 171 | 174 | NAD | [CFT]-x-x-T | ||||||||
METAL | 186 | 186 | Zinc | E | ||||||||
METAL | 249 | 249 | Zinc; via tele nitrogen | H | ||||||||
METAL | 265 | 265 | Zinc; via tele nitrogen | H | ||||||||
BINDING | 144 | 144 | NAD; via carbonyl oxygen | K | ||||||||
BINDING | 153 | 153 | NAD | K |
Size range | 331-394 amino acids |
Related rules | MF_03143 (ARO1 supersedes the current rule) |
Fusion | Nter: MF_00109 (aroK); Cter: <gppA / PPX> |
Comments | Possible wrong start in CHLPN |