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Annotation rule MF_00110
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General rule information [?]

Accession MF_00110
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 41)
Name DHQ_synthase
Scope
Bacteria
Archaea
Templates P07639 (AROB_ECOLI); Q6GGU4 (AROB_STAAR); P9WPX9 (AROB_MYCTU); P56081 (AROB_HELPY): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AROB
Protein name
RecName: Full=3-dehydroquinate synthase;
Short=DHQS;
EC 4.2.3.4;
Gene name
aroB

Comments [?]

Function Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalytic activity RHEA:21968: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
EC 4.2.3.4
Cofactor NAD(+)
Co(2+)
Zn(2+)
Note: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+)
Pathway Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Subcellular location Cytoplasm.
Similarity Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.

Keywords [?]


Gene Ontology [?]

GO:0003856; Molecular function: 3-dehydroquinate synthase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01761; DHQ_synthase; 1;
TIGRFAMs TIGR01357; aroB; 1;
PIRSF PIRSF001455; DHQ_synth; 1;

Features [?]

From: AROB_MYCTU (P9WPX9)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     73     78       NAD     [DES]-[GA]-E-x-x-K  
NP_BIND (Optional)     107     111       NAD     G-[AV]-x-x-D  
NP_BIND (Optional)     131     132       NAD     T-[TS]  
NP_BIND (Optional)     171     174       NAD     [CFT]-x-x-T  
METAL     186     186       Cobalt or zinc     E  
METAL     249     249       Cobalt or zinc; via tele nitrogen     H  
METAL     265     265       Cobalt or zinc; via tele nitrogen     H  
BINDING     144     144       NAD; via carbonyl oxygen     K  
BINDING     153     153       NAD     K  

Additional information [?]

Size range 331-394 amino acids
Related rules MF_03143 (ARO1 supersedes the current rule)
Fusion Nter: MF_00109 (aroK); Cter: <gppA / PPX>
Comments Possible wrong start in CHLPN