HAMAP rule MF_00110
General rule information
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| Accession | MF_00110 |
| Dates | 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 46) |
| Name | DHQ_synthase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P07639 (AROB_ECOLI); Q6GGU4 (AROB_STAAR); P9WPX9 (AROB_MYCTU); P56081 (AROB_HELPY); [ Recover all ] |
| Triggered by |
HAMAP; MF_00110 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AROB |
| Protein name | RecName: Full=3-dehydroquinate synthase; Short=DHQS; EC=4.2.3.4; |
| Gene name | Name=aroB; |
Comments
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| FUNCTION | Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). |
| CATALYTIC ACTIVITY | Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3- dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364, ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4; |
| COFACTOR | Name=NAD(+); Xref=ChEBI:CHEBI:57540; |
| COFACTOR | Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+) |
| PATHWAY | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. |
Keywords
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| Amino-acid biosynthesis |
| Aromatic amino acid biosynthesis |
| Cobalt |
| Cytoplasm |
| Lyase |
| Metal-binding |
| NAD |
| Nucleotide-binding |
| Zinc |
Gene Ontology
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| GO:0003856; Molecular function:3-dehydroquinate synthase activity |
| GO:0009423; Biological process:chorismate biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01761; DHQ_synthase; 1; |
| NCBIfam | TIGR01357; aroB; 1; |
| PIRSF | PIRSF001455; DHQ_synth; 1; |
Features
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| From: AROB_MYCTU (P9WPX9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 73 | 78 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[DES]-[GA]-E-x-x-K | ||||||||
| BINDING | 107 | 111 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G-[AV]-x-x-D | ||||||||
| BINDING | 131 | 132 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
T-[TS] | ||||||||
| BINDING | 171 | 174 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[CFT]-x-x-T | ||||||||
| BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
E | ||||||||
| BINDING | 249 | 249 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 265 | 265 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 144 | 144 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K | ||||||||
| BINDING | 153 | 153 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K | ||||||||
Additional information
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| Size range | 331-394 amino acids |
| Related rules |
MF_03143 |
| Fusion | Nter: MF_00109 (aroK) Cter: <gppA / PPX> |
| Comments | Possible wrong start in CHLPN |