HAMAP rule MF_00110
General rule information
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| Accession | MF_00110 |
| Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 44) |
| Name | DHQ_synthase |
| Scope | Bacteria
Archaea |
| Templates | P07639 (AROB_ECOLI); Q6GGU4 (AROB_STAAR); P9WPX9 (AROB_MYCTU); P56081 (AROB_HELPY): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). |
| Catalytic activity | RHEA:21968: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate
EC 4.2.3.4 |
| Cofactor | NAD(+) |
| Co(2+) Zn(2+) Note: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+) |
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| Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. |
Keywords
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Amino-acid biosynthesis
Aromatic amino acid biosynthesis
Cobalt
Cytoplasm
Lyase
Metal-binding
NAD
Nucleotide-binding
Zinc
Aromatic amino acid biosynthesis
Cobalt
Cytoplasm
Lyase
Metal-binding
NAD
Nucleotide-binding
Zinc
Gene Ontology
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GO:0003856; Molecular function: 3-dehydroquinate synthase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF01761; DHQ_synthase; 1; |
| TIGRFAMs | TIGR01357; aroB; 1; |
| PIRSF | PIRSF001455; DHQ_synth; 1; |
Features
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| From: AROB_MYCTU (P9WPX9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 73 | 78 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [DES]-[GA]-E-x-x-K | ||||||||
| BINDING (Optional) | 107 | 111 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | G-[AV]-x-x-D | ||||||||
| BINDING (Optional) | 131 | 132 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | T-[TS] | ||||||||
| BINDING (Optional) | 171 | 174 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [CFT]-x-x-T | ||||||||
| BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | E | ||||||||
| BINDING | 249 | 249 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | ||||||||
| BINDING | 265 | 265 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 | H | ||||||||
| BINDING | 144 | 144 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | K | ||||||||
| BINDING | 153 | 153 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | K | ||||||||
Additional information
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| Size range | 331-394 amino acids |
| Related rules | MF_03143 (ARO1 supersedes the current rule) |
| Fusion | Nter: MF_00109 (aroK); Cter: <gppA / PPX> |
| Comments | Possible wrong start in CHLPN |