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HAMAP rule MF_00110

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General rule information [?]

Accession MF_00110
Dates 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 46)
Name DHQ_synthase
Scope(s) Bacteria
Archaea
Template(s) P07639 (AROB_ECOLI); Q6GGU4 (AROB_STAAR); P9WPX9 (AROB_MYCTU); P56081 (AROB_HELPY); [ Recover all ]
Triggered by HAMAP; MF_00110 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AROB
Protein name RecName: Full=3-dehydroquinate synthase;
                 Short=DHQS;
                 EC=4.2.3.4;
Gene name Name=aroB;

Comments [?]

FUNCTIONCatalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
CATALYTIC ACTIVITY Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3- dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364, ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4;
COFACTOR Name=NAD(+); Xref=ChEBI:CHEBI:57540;
COFACTOR Name=Co(2+); Xref=ChEBI:CHEBI:48828; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+)
PATHWAYMetabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.

Keywords [?]


Gene Ontology [?]

GO:0003856; Molecular function:3-dehydroquinate synthase activity
GO:0009423; Biological process:chorismate biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01761; DHQ_synthase; 1;
NCBIfam TIGR01357; aroB; 1;
PIRSF PIRSF001455; DHQ_synth; 1;

Features [?]

From: AROB_MYCTU (P9WPX9)
Key From To Description Tag Condition FTGroup
BINDING 73 78 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
[DES]-[GA]-E-x-x-K
BINDING 107 111 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
G-[AV]-x-x-D
BINDING 131 132 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
T-[TS]
BINDING 171 174 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
[CFT]-x-x-T
BINDING 186 186 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
E
BINDING 249 249 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
H
BINDING 265 265 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
H
BINDING 144 144 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
K
BINDING 153 153 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
K

Additional information [?]

Size range 331-394 amino acids
Related rules MF_03143
Fusion Nter: MF_00109 (aroK) Cter: <gppA / PPX>
Comments Possible wrong start in CHLPN



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