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Annotation rule MF_00132
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General rule information [?]

Accession MF_00132
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 34)
Name Top6A
Scope
Archaea
Bacteria
Templates Q57815 (TOP6A_METJA); Q8PUB7 (TOP6A_METMA); O05208 (TOP6A_SACSH): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TOP6A
Protein name
RecName: Full=Type 2 DNA topoisomerase 6 subunit A;
EC 5.6.2.2;
AltName: Full=Type II DNA topoisomerase VI subunit A;
Gene name
top6A

Comments [?]

Function Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Catalytic activity Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2;
Cofactor Mg(2+)
Subunit Homodimer. Heterotetramer of two Top6A and two Top6B chains.
Similarity Belongs to the TOP6A family.

Keywords [?]


Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006265; Biological process: DNA topological change.
GO:0006268; Biological process: DNA unwinding involved in DNA replication.

Cross-references [?]

Pfam PF04406; TP6A_N; 1;
PRINTS PR01550; TOP6AFAMILY; 1;
PR01552; TPISMRASE6A; 1;

Features [?]

From: TOP6A_METJA (Q57815)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     103     103       Nucleophile     Y  
METAL     197     197       Magnesium     E  
METAL     249     249       Magnesium     D  

Additional information [?]

Size range 340-453 amino acids
Related rules None
Fusion None