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Annotation rule MF_00132 |
General rule information
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Accession |
MF_00132 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 34) |
case <OC:Bacteria> or <OC:Archaea>
end case
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Type 2 DNA topoisomerase 6 subunit A;
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EC 5.6.2.2;
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AltName:
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Full=Type II DNA topoisomerase VI subunit A;
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Function |
Relaxes both positive and negative superturns and exhibits a strong decatenase activity. |
Catalytic activity |
Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
Cofactor |
Mg(2+) |
Subunit |
Homodimer. Heterotetramer of two Top6A and two Top6B chains. |
Similarity |
Belongs to the TOP6A family. |
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006265; Biological process: DNA topological change.
GO:0006268; Biological process: DNA unwinding involved in DNA replication.
From: TOP6A_METJA (Q57815) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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103
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103
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Nucleophile
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Y
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METAL
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197
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197
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Magnesium
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E
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METAL
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249
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249
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Magnesium
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D
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Additional information
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Size range |
340-453 amino acids |
Related rules |
None |
Fusion |
None |