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Annotation rule MF_00139
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General rule information [?]

Accession MF_00139
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 32)
Name PurH
Scope
Bacteria
Templates P31335 (PUR9_CHICK); P31939 (PUR9_HUMAN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PUR9
Protein name
RecName: Full=Bifunctional purine biosynthesis protein PurH;
Includes:
RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase;
EC 2.1.2.3;
AltName: Full=AICAR transformylase;
Includes:
RecName: Full=IMP cyclohydrolase;
EC 3.5.4.10;
AltName: Full=ATIC;
AltName: Full=IMP synthase;
AltName: Full=Inosinicase;
Gene name
purH

Comments [?]

Catalytic activity RHEA:22192: (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
EC 2.1.2.3
RHEA:18445: H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
EC 3.5.4.10
Pathway Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.
Domain The IMP cyclohydrolase activity resides in the N-terminal region.
Similarity Belongs to the PurH family.

Keywords [?]

case (<OC:Escherichia> or <OC:Shigella>) and <FT:1>
Acetylation
end case
Hydrolase
Multifunctional enzyme
Purine biosynthesis
Transferase

Gene Ontology [?]

GO:0003937; Molecular function: IMP cyclohydrolase activity.
GO:0004643; Molecular function: phosphoribosylaminoimidazolecarboxamide formyltransferase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

Pfam PF01808; AICARFT_IMPCHas; 1;
PF02142; MGS; 1;
TIGRFAMs TIGR00355; PurH; 1;
PROSITE PS51855; MGS; 1; trigger=PRU01202;

Features [?]

case <OC:Escherichia> or <OC:Shigella>
From: PUR9_ECOLI (P15639)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     287     287       N6-acetyllysine     K  
end case

Additional information [?]

Size range 492-545 amino acids
Related rules None
Fusion None
Comments Divergent THEMA; sequence not included in alignment and not taken into account in size range


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