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Annotation rule MF_00139 |
General rule information
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Accession |
MF_00139 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 32) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Bifunctional purine biosynthesis protein PurH;
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Includes:
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RecName:
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Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase;
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EC 2.1.2.3;
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AltName:
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Full=AICAR transformylase;
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Includes:
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RecName:
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Full=IMP cyclohydrolase;
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EC 3.5.4.10;
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AltName:
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Full=ATIC;
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AltName:
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Full=IMP synthase;
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AltName:
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Full=Inosinicase;
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Catalytic activity |
RHEA:22192: (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
EC 2.1.2.3
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RHEA:18445: H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
EC 3.5.4.10
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Pathway |
Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. |
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Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. |
Domain |
The IMP cyclohydrolase activity resides in the N-terminal region. |
Similarity |
Belongs to the PurH family. |
case (<OC:Escherichia> or <OC:Shigella>) and <FT:1>
end case
GO:0003937; Molecular function: IMP cyclohydrolase activity.
GO:0004643; Molecular function: phosphoribosylaminoimidazolecarboxamide formyltransferase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.
case <OC:Escherichia> or <OC:Shigella>
From: PUR9_ECOLI (P15639) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOD_RES
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287
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287
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N6-acetyllysine
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K
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end case
Additional information
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Size range |
492-545 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Divergent THEMA; sequence not included in alignment and not taken into account in size range |