HAMAP rule MF_00145
General rule information
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| Accession | MF_00145 |
| Dates | 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 39) |
| Name | Phosphoglyc_kinase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P18912 (PGK_GEOSE); Q8GIZ5 (PGK_LACDL); P36204 (PGKT_THEMA); P09403 (PGK_THET8); P61884 (PGK_PYRWO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00145 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PGK |
| Protein name | RecName: Full=Phosphoglycerate kinase; EC=2.7.2.3; |
| Gene name | Name=pgk; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3; |
| PATHWAY | Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 2/5. |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the phosphoglycerate kinase family. |
Keywords
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| case <FT:10> | |
| Acetylation | |
| end case | |
| Cytoplasm | |
| ATP-binding | |
| Glycolysis | |
| Kinase | |
| Nucleotide-binding | |
| Transferase | |
| case <FT:11> or <FT:12> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0004618; Molecular function:phosphoglycerate kinase activity |
| GO:0006096; Biological process:glycolytic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: PGKT_THEMA (P36204) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 353 | 356 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-G-[DEH]-[STAILFM] | ||||||||
| BINDING | 21 | 23 | /ligand="substrate" | D-[LFMYVI]-N | ||||||||
| BINDING | 59 | 62 | /ligand="substrate" | [HQR]-x-[GSDRK]-[RGKNDP] | ||||||||
| BINDING | 36 | 36 | /ligand="substrate" | R | ||||||||
| BINDING | 118 | 118 | /ligand="substrate" | R | ||||||||
| BINDING | 151 | 151 | /ligand="substrate" | R | ||||||||
| BINDING | 201 | 201 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 293 | 293 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| BINDING | 324 | 324 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
E | ||||||||
| From: PGK_ECOLI (P0A799) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| MOD_RES | 84 | 84 | /note="N6-acetyllysine" | K | ||||||||
| end case | ||||||||||||
| From: PGK_BACSU (P40924) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacillaceae> | ||||||||||||
| MOD_RES | 183 | 183 | /note="Phosphoserine" | S | ||||||||
| MOD_RES | 299 | 299 | /note="Phosphothreonine" | T | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 385-419 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: MF_00147 (tpiA); <Unknown> |