HAMAP rule MF_00145

General rule information [?]

Accession	MF_00145
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 39)

Name	Phosphoglyc_kinase

Scope

Bacteria

Archaea

Templates

P18912 (PGK_GEOSE); Q8GIZ5 (PGK_LACDL); P36204 (PGKT_THEMA); P09403 (PGK_THET8); P61884 (PGK_PYRWO): [Recover all]

Triggered by

HAMAP; MF_00145 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PGK

Protein name

RecName:		Full=Phosphoglycerate kinase;
		EC 2.7.2.3;

Gene name

pgk

Comments [?]

Catalytic activity	RHEA:14801: (2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP EC 2.7.2.3
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.
Subunit	Monomer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the phosphoglycerate kinase family.

Keywords [?]

case <FT:10>

Acetylation

end case

Cytoplasm
ATP-binding
Glycolysis
Kinase
Nucleotide-binding
Transferase

case <FT:11> or <FT:12>

Phosphoprotein

end case

Gene Ontology [?]

GO:0004618; Molecular function: phosphoglycerate kinase activity.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00162; PGK; 1;
PRINTS	PR00477; PHGLYCKINASE; 1;
PROSITE	PS00111; PGLYCERATE_KINASE; 1;

Features [?]

From: PGKT_THEMA (P36204)

Key From To Description Tag Condition FTGroup

BINDING 353 356 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-G-[DEH]-[STAILFM]

BINDING 21 23 /ligand="substrate D-[LFMYVI]-N

BINDING 59 62 /ligand="substrate [HQR]-x-[GSDRK]-[RGKNDP]

BINDING (Optional) 36 36 /ligand="substrate R

BINDING (Optional) 118 118 /ligand="substrate R

BINDING (Optional) 151 151 /ligand="substrate R

BINDING (Optional) 201 201 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 K

BINDING (Optional) 293 293 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G

BINDING (Optional) 324 324 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 E

case <OC:Escherichia> or <OC:Shigella>

From: PGK_ECOLI (P0A799)

MOD_RES 84 84 N6-acetyllysine K

end case

case <OC:Bacillaceae>

From: PGK_BACSU (P40924)

MOD_RES 183 183 Phosphoserine S

MOD_RES 299 299 Phosphothreonine T

end case

Additional information [?]

Size range	385-419 amino acids
Related rules	None
Fusion	Nter: None; Cter: MF_00147 (tpiA), <Unknown>

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