HAMAP rule MF_00151
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00151 |
| Accession | MF_00151 |
| Dates | 28-FEB-2005 (Created)
01-JUN-2023 (Last updated, Version 25) |
| Name | PPAT_bact |
| Scope(s) |
Bacteria |
| Template(s) | P0A6I6; O26010; P9WPA5; P63820; Q8DNE6; O34797; Q3JW91; Q831P9; B7V2S6; P63819; Q9WZK0; Q5SJS9; Q8ZJN9; [ Recover all ] |
| Triggered by |
HAMAP; MF_00151 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | COAD |
| Protein name | RecName: Full=Phosphopantetheine adenylyltransferase; EC=2.7.7.3; AltName: Full=Dephospho-CoA pyrophosphorylase; AltName: Full=Pantetheine-phosphate adenylyltransferase; Short=PPAT; |
| Gene name | Name=coaD; |
Comments
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| FUNCTION | Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. |
| CATALYTIC ACTIVITY | Reaction=(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate; Xref=Rhea:RHEA:19801, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57328, ChEBI:CHEBI:61723; EC=2.7.7.3; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)- pantothenate: step 4/5. |
| SUBUNIT | Homohexamer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the bacterial CoaD family. |
Keywords
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| ATP-binding |
| Coenzyme A biosynthesis |
| Cytoplasm |
| Magnesium |
| Nucleotide-binding |
| Nucleotidyltransferase |
| Transferase |
Gene Ontology
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| GO:0004595; Molecular function:pantetheine-phosphate adenylyltransferase activity |
| GO:0015937; Biological process:coenzyme A biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01467; CTP_transf_2; 1; |
| PRINTS | PR01020; LPSBIOSNTHSS; 1; |
| NCBIfam | TIGR01510; CoaD_prev_kdtB; 1; |
| NCBIfam | TIGR00125; Cyt_tran_rel; 1; |
Features
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| From: COAD_ECOLI (P0A6I6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS]-[FYL] | ||||||||
| BINDING | 89 | 91 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-R | ||||||||
| BINDING | 124 | 130 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| BINDING | 10 | 10 | /ligand="substrate" | [TS] | ||||||||
| BINDING | 18 | 18 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
H | ||||||||
| BINDING | 42 | 42 | /ligand="substrate" | K | ||||||||
| BINDING | 74 | 74 | /ligand="substrate" | [MLVIATS] | ||||||||
| BINDING | 88 | 88 | /ligand="substrate" | [RK] | ||||||||
| BINDING | 99 | 99 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
E | ||||||||
| SITE | 18 | 18 | /note="Transition state stabilizer" | H | ||||||||
Additional information
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| Size range | 140-191 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in ZYMMO |