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Annotation rule MF_00151
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General rule information [?]

Accession MF_00151
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 28)
Name PPAT_bact
Scope
Bacteria
Templates P0A6I6 (COAD_ECOLI); O26010 (COAD_HELPY); P9WPA5 (COAD_MYCTU); P63820 (COAD_STAAW); Q8DNE6 (COAD_STRR6); O34797 (COAD_BACSU); Q3JW91 (COAD_BURP1); Q831P9 (COAD_ENTFA); B7V2S6 (COAD_PSEA8); P63819 (COAD_STAAN); Q9WZK0 (COAD_THEMA); Q5SJS9 (COAD_THET8); Q8ZJN9 (COAD_YERPE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COAD
Protein name
RecName: Full=Phosphopantetheine adenylyltransferase;
EC 2.7.7.3;
AltName: Full=Dephospho-CoA pyrophosphorylase;
AltName: Full=Pantetheine-phosphate adenylyltransferase;
Short=PPAT;
Gene name
coaD

Comments [?]

Function Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity RHEA:19801: ATP + D-pantetheine 4'-phosphate + H(+) = 3'-dephospho-CoA + diphosphate
EC 2.7.7.3
Cofactor Mg(2+)
Pathway Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Subunit Homohexamer.
Subcellular location Cytoplasm.
Similarity Belongs to the bacterial CoaD family.

Keywords [?]


Gene Ontology [?]

GO:0004595; Molecular function: pantetheine-phosphate adenylyltransferase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01467; CTP_transf_2; 1;
PRINTS PR01020; LPSBIOSNTHSS; 1;
TIGRFAMs TIGR01510; CoaD_prev_kdtB; 1;
TIGR00125; Cyt_tran_rel; 1;

Features [?]

From: COAD_ECOLI (P0A6I6)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     10     11       ATP     [TS]-[FYL]  
NP_BIND     89     91       ATP     G-x-R  
NP_BIND     124     130       ATP        
BINDING     10     10       Substrate     [TS]  
BINDING     18     18       ATP     H  
BINDING     42     42       Substrate     K  
BINDING     74     74       Substrate; via amide nitrogen     [MLVIATS]  
BINDING     88     88       Substrate     [RK]  
BINDING     99     99       ATP     E  
SITE     18     18       Transition state stabilizer     H  

Additional information [?]

Size range 140-191 amino acids
Related rules None
Fusion None
Comments Possible wrong start in ZYMMO