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Annotation rule MF_00159 |
General rule information
[?]
Accession |
MF_00159 |
Dates |
18-JAN-2002 (Created) 18-NOV-2019 (Last updated, Version 34) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Cyanobacteria>
Protein name |
RecName:
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Full=4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin);
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EC 1.17.7.1;
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AltName:
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Full=1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase;
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else
Protein name |
RecName:
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Full=4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin);
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EC 1.17.7.3;
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AltName:
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Full=1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase;
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end case
Function |
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. |
case <OC:Cyanobacteria> or <OG:Chloroplast>
Catalytic activity |
RHEA:26119: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
EC 1.17.7.1
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else
Catalytic activity |
RHEA:43604: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]
EC 1.17.7.3
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end case
case <FTGroup:1>
end case
Pathway |
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6. |
Similarity |
Belongs to the IspG family. |
case <FTGroup:1>
end case
case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
end case
GO:0046429; Molecular function: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.
From: ISPG_AQUAE (O67496) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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METAL
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265
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265
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Iron-sulfur (4Fe-4S)
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C
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1
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METAL
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268
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268
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Iron-sulfur (4Fe-4S)
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C
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1
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METAL
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300
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300
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Iron-sulfur (4Fe-4S)
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C
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1
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METAL
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307
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307
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Iron-sulfur (4Fe-4S)
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E
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1
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Additional information
[?]
Size range |
344-663 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Insertion in BACFN, BACFR, BACTN, CHLAB, CHLCV, CHLMU, CHLPN, CHLTE, CHLTR, LEPIC, LEPIN, PARUW and PORGI. Possible wrong start in CHLTE, DESVH and RHOPA. |