HAMAP rule MF_00159
General rule information
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Accession | MF_00159 |
Dates | 18-JAN-2002 (Created) 1-JUN-2023 (Last updated, Version 38) |
Name | IspG |
Scope | Bacteria |
Templates | P62620 (ISPG_ECOLI); Q84GJ3 (ISPG_THETH); O67496 (ISPG_AQUAE); Q72H18 (ISPG_THET2): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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case <OC:Cyanobacteriota>
Protein name |
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else
Protein name |
|
end case
Gene name |
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Comments
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Function | Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. |
case <OC:Cyanobacteriota> or <OG:Chloroplast>
Catalytic activity | RHEA:26119: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
EC 1.17.7.1 |
else
Catalytic activity | RHEA:43604: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]
EC 1.17.7.3 |
end case
case <FTGroup:1>
Cofactor | [4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster. |
end case
Pathway | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6. |
Similarity | Belongs to the IspG family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
end case
GO:0046429; Molecular function: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity.
GO:0016114; Biological process: terpenoid biosynthetic process.
GO:0016114; Biological process: terpenoid biosynthetic process.
Cross-references
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Features
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From: ISPG_AQUAE (O67496) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 265 | 265 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 268 | 268 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 300 | 300 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 307 | 307 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | E | 1 |
Additional information
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Size range | 344-663 amino acids |
Related rules | None |
Fusion | None |
Comments | Insertion in BACFN, BACFR, BACTN, CHLAB, CHLCV, CHLMU, CHLPN, CHLTE, CHLTR, LEPIC, LEPIN, PARUW and PORGI. Possible wrong start in CHLTE, DESVH and RHOPA. |