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HAMAP rule MF_00161

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General rule information [?]

Accession MF_00161
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 43)
Name LspA
Scope
Bacteria
Templates P00804 (LSPA_ECOLI); Q45479 (LSPA_BACSU); Q9HVM5 (LSPA_PSEAE); Q2FHP2 (LSPA_STAA3): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LSPA
Protein name
RecName: Full=Lipoprotein signal peptidase;
EC 3.4.23.36;
AltName: Full=Prolipoprotein signal peptidase;
AltName: Full=Signal peptidase II;
Short=SPase II;
Gene name
lspA

Comments [?]

Function This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Catalytic activity Reaction=Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.; EC=3.4.23.36;
Pathway Protein modification; lipoprotein biosynthesis (signal peptide cleavage).
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the peptidase A8 family.

Keywords [?]

Hydrolase
Protease
Aspartyl protease
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0004190; Molecular function: aspartic-type endopeptidase activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01252; Peptidase_A8; 1;
PRINTS PR00781; LIPOSIGPTASE; 1;
NCBIfam TIGR00077; LspA; 1;
PROSITE PS00855; SPASE_II; 1;

Computed features [?]

General Transmembrane; -; 4-5; trigger=yes;

Features [?]

From: LSPA_PSEAE (Q9HVM5)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     124     124             D  
ACT_SITE     143     143             D  

Additional information [?]

Size range 145-304 amino acids
Related rules None
Fusion Nter: <Unknown>; Cter: None


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