HAMAP rule MF_00161
General rule information
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| Accession | MF_00161 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 43) |
| Name | LspA |
| Scope(s) |
Bacteria |
| Template(s) | P00804 (LSPA_ECOLI); Q45479 (LSPA_BACSU); Q9HVM5 (LSPA_PSEAE); Q2FHP2 (LSPA_STAA3); [ Recover all ] |
| Triggered by |
HAMAP; MF_00161 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LSPA |
| Protein name | RecName: Full=Lipoprotein signal peptidase; EC=3.4.23.36; AltName: Full=Prolipoprotein signal peptidase; AltName: Full=Signal peptidase II; Short=SPase II; |
| Gene name | Name=lspA; |
Comments
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| FUNCTION | This protein specifically catalyzes the removal of signal peptides from prolipoproteins. |
| CATALYTIC ACTIVITY | Reaction=Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.; EC=3.4.23.36; |
| PATHWAY | Protein modification; lipoprotein biosynthesis (signal peptide cleavage). |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the peptidase A8 family. |
Keywords
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| Hydrolase | |
| Protease | |
| Aspartyl protease | |
| Cell membrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0004190; Molecular function:aspartic-type endopeptidase activity |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01252; Peptidase_A8; 1; |
| PRINTS | PR00781; LIPOSIGPTASE; 1; |
| NCBIfam | TIGR00077; LspA; 1; |
| PROSITE | PS00855; SPASE_II; 1; |
| General | Transmembrane; -; 4-5; |
Features
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| From: LSPA_PSEAE (Q9HVM5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 124 | 124 | D | |||||||||
| ACT_SITE | 143 | 143 | D | |||||||||
Additional information
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| Size range | 145-304 amino acids |
| Related rules |
None |
| Fusion | Nter: <Unknown> Cter: None |