HAMAP rule MF_00177

General rule information [?]

Accession	MF_00177
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 35)

Name	Lys_tRNA_synth_class1

Scope

Bacteria

Archaea

Templates

O57963 (SYK_PYRHO); O51603 (SYK_BORBU); P0CW67 (SYK_METMP): [Recover all]

Triggered by

HAMAP; MF_00177 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SYK

Protein name

RecName:		Full=Lysine--tRNA ligase;
		EC 6.1.1.6;
AltName:		Full=Lysyl-tRNA synthetase;
		Short=LysRS;

Gene name

lysS

Comments [?]

Catalytic activity	RHEA:20792: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys) EC 6.1.1.6
Subcellular location	Cytoplasm.
Similarity	Belongs to the class-I aminoacyl-tRNA synthetase family.

Keywords [?]

Cytoplasm
Aminoacyl-tRNA synthetase
Protein biosynthesis
Ligase
ATP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004824; Molecular function: lysine-tRNA ligase activity.
GO:0006430; Biological process: lysyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01921; tRNA-synt_1f; 1;
TIGRFAMs	TIGR00467; LysS_arch; 1;
PROSITE	PS00178; AA_TRNA_LIGASE_I; 1;

Features [?]

From: SYK_RICPR (Q9ZDF8)

Key From To Description Tag Condition FTGroup

MOTIF 44 52 'HIGH' region [AIPTV]-S-G-x-[ILPQV]-H-[ILMV]-G-[HNRST]

MOTIF 290 294 'KMSKS' region [ADKP]-[FILM]-[HKS]-[GKS]-S

BINDING 293 293 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 K

Additional information [?]

Size range	493-580 amino acids
Related rules	None
Fusion	None
Comments	Lysyl-tRNA synthesis is catalyzed by two unrelated families of tRNA synthetase; class-I or class-II. Usually only one or the other is present, however Methanosarcina seem to have both.

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