HAMAP rule MF_00177
General rule information
[?]
Accession | MF_00177 |
Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 36) |
Name | Lys_tRNA_synth_class1 |
Scope(s) |
Bacteria Archaea |
Template(s) | O57963 (SYK_PYRHO); O51603 (SYK_BORBU); P0CW67 (SYK_METMP); [ Recover all ] |
Triggered by |
HAMAP; MF_00177 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | SYK |
Protein name | RecName: Full=Lysine--tRNA ligase; EC=6.1.1.6; AltName: Full=Lysyl-tRNA synthetase; Short=LysRS; |
Gene name | Name=lysS; |
Comments
[?]
CATALYTIC ACTIVITY | Reaction=ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl- tRNA(Lys); Xref=Rhea:RHEA:20792, Rhea:RHEA-COMP:9696, Rhea:RHEA- COMP:9697, ChEBI:CHEBI:30616, ChEBI:CHEBI:32551, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78529, ChEBI:CHEBI:456215; EC=6.1.1.6; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class-I aminoacyl-tRNA synthetase family. |
Keywords
[?]
Gene Ontology
[?]
GO:0005524; Molecular function:ATP binding |
GO:0004824; Molecular function:lysine-tRNA ligase activity |
GO:0006430; Biological process:lysyl-tRNA aminoacylation |
GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
Pfam | PF01921; tRNA-synt_1f; 1; |
NCBIfam | TIGR00467; LysS_arch; 1; |
PROSITE | PS00178; AA_TRNA_LIGASE_I; 1; |
Features
[?]
From: SYK_RICPR (Q9ZDF8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 44 | 52 | /note="'HIGH' region" | [AIPTV]-S-G-x-[ILPQV]-H-[ILMV]-G-[HNRST] | ||||||||
MOTIF | 290 | 294 | /note="'KMSKS' region" | [ADKP]-[FILM]-[HKS]-[GKS]-S | ||||||||
BINDING | 293 | 293 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K |
Additional information
[?]
Size range | 493-580 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Lysyl-tRNA synthesis is catalyzed by two unrelated families of tRNA synthetase; class-I or class-II. Usually only one or the other is present, however Methanosarcina seem to have both. |