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HAMAP rule MF_00217

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General rule information [?]

Accession MF_00217
Dates 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 27)
Name Mevalonate_kinase
Scope(s) Archaea
Template(s) Q58487 (MVK_METJA); Q980D2 (MVK_SACS2); [ Recover all ]
Triggered by HAMAP; MF_00217 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MVK
Protein name RecName: Full=Mevalonate kinase;
                 Short=MK;
                 Short=MVK;
                 EC=2.7.1.36;
Gene name Name=mvk;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
CATALYTIC ACTIVITY Reaction=(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+); Xref=Rhea:RHEA:17065, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36464, ChEBI:CHEBI:58146, ChEBI:CHEBI:456216; EC=2.7.1.36;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the GHMP kinase family. Mevalonate kinase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0000287; Molecular function:magnesium ion binding
GO:0004496; Molecular function:mevalonate kinase activity
GO:0008299; Biological process:isoprenoid biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF08544; GHMP_kinases_C; 1;
Pfam PF00288; GHMP_kinases_N; 1;
PRINTS PR00959; MEVGALKINASE; 1;
NCBIfam TIGR00549; Mevalon_kin; 1;
PROSITE PS00627; GHMP_KINASES_ATP; 1;

Features [?]

From: MVK_METJA (Q58487)
Key From To Description Tag Condition FTGroup
BINDING 104 114 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
P-x(3)-G-L-G-S-S-A-[SA]
ACT_SITE 155 155 /note="Proton acceptor" D

Additional information [?]

Size range 284-337 amino acids
Related rules MF_00384
Fusion Nter: None Cter: None



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