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Annotation rule MF_00217
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General rule information [?]

Accession MF_00217
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 24)
Name Mevalonate_kinase
Scope
Archaea
Templates Q58487 (MVK_METJA); Q980D2 (MVK_SACS2): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MVK
Protein name
RecName: Full=Mevalonate kinase;
Short=MK;
Short=MVK;
EC 2.7.1.36;
Gene name
mvk

Comments [?]

Function Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Catalytic activity RHEA:17065: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)
EC 2.7.1.36
Cofactor Mg(2+)
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0004496; Molecular function: mevalonate kinase activity.
GO:0008299; Biological process: isoprenoid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF08544; GHMP_kinases_C; 1;
PF00288; GHMP_kinases_N; 1;
PRINTS PR00959; MEVGALKINASE; 1;
TIGRFAMs TIGR00549; Mevalon_kin; 1;
PROSITE PS00627; GHMP_KINASES_ATP; 1;

Features [?]

From: MVK_METJA (Q58487)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     104     114       ATP     P-x(3)-G-L-G-S-S-A-[SA]  
ACT_SITE     155     155       Proton acceptor     D  

Additional information [?]

Size range 284-337 amino acids
Related rules MF_00384 (KHSE)
Fusion None