HAMAP rule MF_00217
General rule information
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Accession | MF_00217 |
Dates | 1-JUN-2001 (Created)
12-MAR-2024 (Last updated, Version 28) |
Name | Mevalonate_kinase |
Scope(s) |
Archaea |
Template(s) | Q58487 (MVK_METJA); Q980D2 (MVK_SACS2); [ Recover all ] |
Triggered by |
HAMAP; MF_00217 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MVK |
Protein name | RecName: Full=Mevalonate kinase; Short=MK; Short=MVK; EC=2.7.1.36; |
Gene name | Name=mvk; |
Comments
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FUNCTION | Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. |
CATALYTIC ACTIVITY | Reaction=(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+); Xref=Rhea:RHEA:17065, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36464, ChEBI:CHEBI:58146, ChEBI:CHEBI:456216; EC=2.7.1.36; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
PATHWAY | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the GHMP kinase family. Mevalonate kinase subfamily. |
Keywords
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Cytoplasm |
Transferase |
Kinase |
ATP-binding |
Nucleotide-binding |
Magnesium |
Isoprene biosynthesis |
Lipid biosynthesis |
Lipid metabolism |
Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0000287; Molecular function:magnesium ion binding |
GO:0004496; Molecular function:mevalonate kinase activity |
GO:0019287; Biological process:isopentenyl diphosphate biosynthetic process, mevalonate pathway |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF08544; GHMP_kinases_C; 1; |
Pfam | PF00288; GHMP_kinases_N; 1; |
PRINTS | PR00959; MEVGALKINASE; 1; |
NCBIfam | TIGR00549; Mevalon_kin; 1; |
PROSITE | PS00627; GHMP_KINASES_ATP; 1; |
Features
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From: MVK_METJA (Q58487) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 104 | 114 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
P-x(3)-G-L-G-S-S-A-[SA] | ||||||||
ACT_SITE | 155 | 155 | /note="Proton acceptor" | D |
Additional information
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Size range | 284-337 amino acids |
Related rules |
MF_00384 |
Fusion | Nter: None Cter: None |