HAMAP rule MF_00217

General rule information [?]

Accession	MF_00217
Dates	1-JUN-2001 (Created) 12-MAR-2024 (Last updated, Version 28)
Name	Mevalonate_kinase
Scope(s)	Archaea
Template(s)	Q58487 (MVK_METJA); Q980D2 (MVK_SACS2); [ Recover all ]
Triggered by	HAMAP; MF_00217 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MVK
Protein name	RecName: Full=Mevalonate kinase; Short=MK; Short=MVK; EC=2.7.1.36;
Gene name	Name=mvk;

Comments [?]

FUNCTION	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
CATALYTIC ACTIVITY	Reaction=(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+); Xref=Rhea:RHEA:17065, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36464, ChEBI:CHEBI:58146, ChEBI:CHEBI:456216; EC=2.7.1.36;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAY	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
SUBUNIT	Homodimer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0000287; Molecular function:magnesium ion binding

GO:0004496; Molecular function:mevalonate kinase activity

GO:0019287; Biological process:isopentenyl diphosphate biosynthetic process, mevalonate pathway

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: MVK_METJA (Q58487)

Key

From

Description

Tag

Condition

FTGroup

BINDING

104

114

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

P-x(3)-G-L-G-S-S-A-[SA]

ACT_SITE

155

/note="Proton acceptor"

Additional information [?]