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HAMAP rule MF_00246
General rule information
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| Accession | MF_00246 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | Galactokinase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A6T3 (GAL1_ECOLI); Q9HHB6 (GAL1_PYRFU); Q9R7D7 (GAL1_LACLA); O58107 (GAL1_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00246 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GAL1 |
| Protein name | RecName: Full=Galactokinase; EC=2.7.1.6; AltName: Full=Galactose kinase; |
| Gene name | Name=galK; |
Comments
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| FUNCTION | Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). |
| CATALYTIC ACTIVITY | Reaction=alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+); Xref=Rhea:RHEA:13553, ChEBI:CHEBI:15378, ChEBI:CHEBI:28061, ChEBI:CHEBI:30616, ChEBI:CHEBI:58336, ChEBI:CHEBI:456216; EC=2.7.1.6; |
| PATHWAY | Carbohydrate metabolism; galactose metabolism. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the GHMP kinase family. GalK subfamily. |
Keywords
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| ATP-binding |
| Carbohydrate metabolism |
| Cytoplasm |
| Galactose metabolism |
| Kinase |
| Magnesium |
| Metal-binding |
| Nucleotide-binding |
| Transferase |
Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0005524; Molecular function:ATP binding |
| GO:0004335; Molecular function:galactokinase activity |
| GO:0006012; Biological process:galactose metabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF10509; GalKase_gal_bdg; 1; |
| Pfam | PF08544; GHMP_kinases_C; 1; |
| Pfam | PF00288; GHMP_kinases_N; 1; |
| PIRSF | PIRSF000530; Galactokinase; 1; |
| PRINTS | PR00473; GALCTOKINASE; 1; |
| PRINTS | PR00959; MEVGALKINASE; 1; |
| NCBIfam | TIGR00131; Gal_kin; 1; |
| PROSITE | PS00106; GALACTOKINASE; 1; |
| PROSITE | PS00627; GHMP_KINASES_ATP; 1; |
Features
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| From: GAL1_PYRFU (Q9HHB6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 101 | 107 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GAS]-[AS]-[GS]-x-S-S-S | ||||||||
| BINDING | 17 | 20 | /ligand="substrate" | E-[HY]-x-D | ||||||||
| ACT_SITE | 151 | 151 | /note="Proton acceptor" | D | ||||||||
| BINDING | 107 | 107 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
S | ||||||||
| BINDING | 139 | 139 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 49 | 49 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
S | ||||||||
| BINDING | 200 | 200 | /ligand="substrate" | Y | ||||||||
| SITE | 11 | 11 | /note="Transition state stabilizer" | R | ||||||||
Additional information
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| Size range | 350-399 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Divergent galK in TREPA: TP0418; not included in alignment |