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Annotation rule MF_00246
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General rule information [?]

Accession MF_00246
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 29)
Name Galactokinase
Scope
Bacteria
Archaea
Templates P0A6T3 (GAL1_ECOLI); Q9HHB6 (GAL1_PYRFU); Q9R7D7 (GAL1_LACLA); O58107 (GAL1_PYRHO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GAL1
Protein name
RecName: Full=Galactokinase;
EC 2.7.1.6;
AltName: Full=Galactose kinase;
Gene name
galK

Comments [?]

Function Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
Catalytic activity RHEA:13553: alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)
EC 2.7.1.6
Pathway Carbohydrate metabolism; galactose metabolism.
Subcellular location Cytoplasm.
Similarity Belongs to the GHMP kinase family. GalK subfamily.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0004335; Molecular function: galactokinase activity.
GO:0006012; Biological process: galactose metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF10509; GalKase_gal_bdg; 1;
PF08544; GHMP_kinases_C; 1;
PF00288; GHMP_kinases_N; 1;
PIRSF PIRSF000530; Galactokinase; 1;
PRINTS PR00473; GALCTOKINASE; 1;
PR00959; MEVGALKINASE; 1;
TIGRFAMs TIGR00131; Gal_kin; 1;
PROSITE PS00106; GALACTOKINASE; 1;
PS00627; GHMP_KINASES_ATP; 1;

Features [?]

From: GAL1_PYRFU (Q9HHB6)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     101     107       ATP     [GAS]-[AS]-[GS]-x-S-S-S  
REGION     17     20       Substrate binding     E-[HY]-x-D  
ACT_SITE     151     151       Proton acceptor     D  
METAL     107     107       Magnesium     S  
METAL     139     139       Magnesium     E  
BINDING (Optional)     49     49       ATP     S  
BINDING     200     200       Substrate     Y  
SITE     11     11       Transition state stabilizer     R  

Additional information [?]

Size range 350-399 amino acids
Related rules None
Fusion None
Comments Divergent galK in TREPA: TP0418; not included in alignment