HAMAP rule MF_00246

General rule information [?]

Accession	MF_00246
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 32)

Name	Galactokinase

Scope

Bacteria

Archaea

Templates

P0A6T3 (GAL1_ECOLI); Q9HHB6 (GAL1_PYRFU); Q9R7D7 (GAL1_LACLA); O58107 (GAL1_PYRHO): [Recover all]

Triggered by

HAMAP; MF_00246 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GAL1

Protein name

RecName:		Full=Galactokinase;
		EC 2.7.1.6;
AltName:		Full=Galactose kinase;

Gene name

galK

Comments [?]

Function	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
Catalytic activity	RHEA:13553: alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+) EC 2.7.1.6
Pathway	Carbohydrate metabolism; galactose metabolism.
Subcellular location	Cytoplasm.
Similarity	Belongs to the GHMP kinase family. GalK subfamily.

Keywords [?]

ATP-binding
Carbohydrate metabolism
Cytoplasm
Galactose metabolism
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0004335; Molecular function: galactokinase activity.
GO:0006012; Biological process: galactose metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF10509; GalKase_gal_bdg; 1;
	PF08544; GHMP_kinases_C; 1;
	PF00288; GHMP_kinases_N; 1;
PIRSF	PIRSF000530; Galactokinase; 1;
PRINTS	PR00473; GALCTOKINASE; 1;
	PR00959; MEVGALKINASE; 1;
TIGRFAMs	TIGR00131; Gal_kin; 1;
PROSITE	PS00106; GALACTOKINASE; 1;
	PS00627; GHMP_KINASES_ATP; 1;

Features [?]

From: GAL1_PYRFU (Q9HHB6)

Key From To Description Tag Condition FTGroup

BINDING 101 107 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [GAS]-[AS]-[GS]-x-S-S-S

BINDING 17 20 /ligand="substrate E-[HY]-x-D

ACT_SITE 151 151 Proton acceptor D

BINDING 107 107 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 S

BINDING 139 139 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E

BINDING (Optional) 49 49 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 S

BINDING 200 200 /ligand="substrate Y

SITE 11 11 Transition state stabilizer R

Additional information [?]

Size range	350-399 amino acids
Related rules	None
Fusion	None
Comments	Divergent galK in TREPA: TP0418; not included in alignment

View rule in raw text format (no links)