HAMAP rule MF_00247
General rule information
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Accession | MF_00247 |
Dates | 1-JUN-2001 (Created)
28-JUN-2024 (Last updated, Version 32) |
Name | SthA |
Scope(s) |
Bacteria |
Template(s) | P27306 (STHA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00247 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | STHA |
Protein name | RecName: Full=Soluble pyridine nucleotide transhydrogenase; Short=STH; EC=1.6.1.1; AltName: Full=NAD(P)(+) transhydrogenase [B-specific]; |
case <OC:Enterobacteriaceae> | |
Gene name | Name=sthA; Synonyms=udhA; |
end case | |
case not <OC:Enterobacteriaceae> | |
Gene name | Name=sthA; |
end case |
Comments
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FUNCTION | Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. |
CATALYTIC ACTIVITY | Reaction=NAD(+) + NADPH = NADH + NADP(+); Xref=Rhea:RHEA:11692, ChEBI:CHEBI:57540, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=1.6.1.1; |
COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. |
Keywords
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Gene Ontology
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GO:0003957; Molecular function:NAD(P)+ transhydrogenase (Si-specific) activity |
GO:0006739; Biological process:NADP metabolic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00070; Pyr_redox; 1; |
Pfam | PF07992; Pyr_redox_2; 1; |
Pfam | PF02852; Pyr_redox_dim; 1; |
PRINTS | PR00368; FADPNR; 1; |
PRINTS | PR00945; HGRDTASE; 1; |
Features
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From: STHA_ECOLI (P27306) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 36 | 45 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
Additional information
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Size range | 463-471 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |