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HAMAP rule MF_00247

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General rule information [?]

Accession MF_00247
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 31)
Name SthA
Scope
Bacteria
Template P27306 (STHA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
STHA
Protein name
RecName: Full=Soluble pyridine nucleotide transhydrogenase;
Short=STH;
EC 1.6.1.1;
AltName: Full=NAD(P)(+) transhydrogenase [B-specific];
case <OC:Enterobacteriaceae>
Gene name
sthA, udhA
end case
case not <OC:Enterobacteriaceae>
Gene name
sthA
end case

Comments [?]

Function Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
Catalytic activity RHEA:11692: NAD(+) + NADPH = NADH + NADP(+)
EC 1.6.1.1
Cofactor FAD
Note: Binds 1 FAD per subunit.
Subcellular location Cytoplasm.
Similarity Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Keywords [?]

Cytoplasm
Oxidoreductase
Flavoprotein
FAD
NADP
NAD

Gene Ontology [?]

GO:0003957; Molecular function: NAD(P)+ transhydrogenase (B-specific) activity.
GO:0006739; Biological process: NADP metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00070; Pyr_redox; 1;
PF07992; Pyr_redox_2; 1;
PF02852; Pyr_redox_dim; 1;
PRINTS PR00368; FADPNR; 1;
PR00945; HGRDTASE; 1;

Features [?]

From: STHA_ECOLI (P27306)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     36     45       /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692        

Additional information [?]

Size range 463-471 amino acids
Related rules None
Fusion None


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