HAMAP rule MF_00247
General rule information
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| Accession | MF_00247 |
| Dates | 1-JUN-2001 (Created)
28-JUN-2024 (Last updated, Version 32) |
| Name | SthA |
| Scope(s) |
Bacteria |
| Template(s) | P27306 (STHA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00247 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | STHA |
| Protein name | RecName: Full=Soluble pyridine nucleotide transhydrogenase; Short=STH; EC=1.6.1.1; AltName: Full=NAD(P)(+) transhydrogenase [B-specific]; |
| case <OC:Enterobacteriaceae> | |
| Gene name | Name=sthA; Synonyms=udhA; |
| end case | |
| case not <OC:Enterobacteriaceae> | |
| Gene name | Name=sthA; |
| end case | |
Comments
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| FUNCTION | Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. |
| CATALYTIC ACTIVITY | Reaction=NAD(+) + NADPH = NADH + NADP(+); Xref=Rhea:RHEA:11692, ChEBI:CHEBI:57540, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=1.6.1.1; |
| COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. |
Keywords
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Gene Ontology
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| GO:0003957; Molecular function:NAD(P)+ transhydrogenase (Si-specific) activity |
| GO:0006739; Biological process:NADP metabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00070; Pyr_redox; 1; |
| Pfam | PF07992; Pyr_redox_2; 1; |
| Pfam | PF02852; Pyr_redox_dim; 1; |
| PRINTS | PR00368; FADPNR; 1; |
| PRINTS | PR00945; HGRDTASE; 1; |
Features
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| From: STHA_ECOLI (P27306) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 36 | 45 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
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Additional information
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| Size range | 463-471 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |