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HAMAP rule MF_00247

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General rule information [?]

Accession MF_00247
Dates 1-JUN-2001 (Created)
28-JUN-2024 (Last updated, Version 32)
Name SthA
Scope(s) Bacteria
Template(s) P27306 (STHA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00247 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier STHA
Protein name RecName: Full=Soluble pyridine nucleotide transhydrogenase;
                 Short=STH;
                 EC=1.6.1.1;
AltName: Full=NAD(P)(+) transhydrogenase [B-specific];
case <OC:Enterobacteriaceae>
Gene name Name=sthA; Synonyms=udhA;
end case
case not <OC:Enterobacteriaceae>
Gene name Name=sthA;
end case

Comments [?]

FUNCTIONConversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
CATALYTIC ACTIVITY Reaction=NAD(+) + NADPH = NADH + NADP(+); Xref=Rhea:RHEA:11692, ChEBI:CHEBI:57540, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945, ChEBI:CHEBI:58349; EC=1.6.1.1;
COFACTOR Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Keywords [?]


Gene Ontology [?]

GO:0003957; Molecular function:NAD(P)+ transhydrogenase (Si-specific) activity
GO:0006739; Biological process:NADP metabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00070; Pyr_redox; 1;
Pfam PF07992; Pyr_redox_2; 1;
Pfam PF02852; Pyr_redox_dim; 1;
PRINTS PR00368; FADPNR; 1;
PRINTS PR00945; HGRDTASE; 1;

Features [?]

From: STHA_ECOLI (P27306)
Key From To Description Tag Condition FTGroup
BINDING 36 45 /ligand="FAD"
/ligand_id="ChEBI:CHEBI:57692"

Additional information [?]

Size range 463-471 amino acids
Related rules None
Fusion Nter: None Cter: None



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