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HAMAP rule MF_00260

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General rule information [?]

Accession MF_00260
Dates 1-JUN-2001 (Created)
15-FEB-2024 (Last updated, Version 41)
Name Porphobil_deam
Scope(s) Bacteria
Archaea
Template(s) P06983 (HEM3_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00260 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HEM3
case <OC:Bacteria>
Protein name RecName: Full=Porphobilinogen deaminase;
                 Short=PBG;
                 EC=2.5.1.61;
AltName: Full=Hydroxymethylbilane synthase;
                 Short=HMBS;
AltName: Full=Pre-uroporphyrinogen synthase;
end case
case <OC:Archaea>
Protein name RecName: Full=Probable porphobilinogen deaminase;
                 Short=PBG;
                 EC=2.5.1.61;
AltName: Full=Hydroxymethylbilane synthase;
                 Short=HMBS;
AltName: Full=Pre-uroporphyrinogen synthase;
end case
Gene name Name=hemC;

Comments [?]

FUNCTIONTetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
CATALYTIC ACTIVITY Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+); Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61;
COFACTOR Name=dipyrromethane; Xref=ChEBI:CHEBI:60342; Note=Binds 1 dipyrromethane group covalently.;
case not <Property:PHOTOSYN>
PATHWAYPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
end case
case <Property:PHOTOSYN>
PATHWAYPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
PATHWAYPorphyrin-containing compound metabolism; chlorophyll biosynthesis.
end case
case <OC:Bacteria>
SUBUNITMonomer.
end case
MISCELLANEOUSThe porphobilinogen subunits are added to the dipyrromethane group.
SIMILARITYBelongs to the HMBS family.

Keywords [?]

Porphyrin biosynthesis
case <Property:PHOTOSYN>
Chlorophyll biosynthesis
end case
Transferase

Gene Ontology [?]

GO:0004418; Molecular function:hydroxymethylbilane synthase activity
case <Property:PHOTOSYN>
GO:0015995; Biological process:chlorophyll biosynthetic process
end case
GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process

Cross-references [?]

Pfam PF01379; Porphobil_deam; 1;
PRINTS PR00151; PORPHBDMNASE; 1;
NCBIfam TIGR00212; HemC; 1;
PROSITE PS00533; PORPHOBILINOGEN_DEAM; 1;

Features [?]

From: HEM3_ECOLI (P06983)
Key From To Description Tag Condition FTGroup
MOD_RES 242 242 /note="S-(dipyrrolylmethanemethyl)cysteine" C

Additional information [?]

Size range 282-395 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Chlamydial hemC are divergent and lack the cofactor binding site, they are shorter and they have not been included in the alignment. HALSA and PAEMA have atypical inserts. RPE1 type insert in RICCN.



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