HAMAP rule MF_00260
General rule information
[?]
Accession | MF_00260 |
Dates | 1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 39) |
Name | Porphobil_deam |
Scope | Bacteria
Archaea |
Template | P06983 (HEM3_ECOLI) |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
case <OC:Bacteria>
Protein name |
|
end case
case <OC:Archaea>
Protein name |
|
end case
Gene name |
|
Comments
[?]
Function | Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. |
Catalytic activity | RHEA:13185: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)
EC 2.5.1.61 |
Cofactor | dipyrromethane Note: Binds 1 dipyrromethane group covalently. |
case not <Property:PHOTOSYN>
Pathway | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. |
end case
case <Property:PHOTOSYN>
Pathway | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. |
Porphyrin-containing compound metabolism; chlorophyll biosynthesis. |
end case
case <OC:Bacteria>
Subunit | Monomer. |
end case
Miscellaneous | The porphobilinogen subunits are added to the dipyrromethane group. |
Similarity | Belongs to the HMBS family. |
Keywords
[?]
case <Property:PHOTOSYN>
end case
Gene Ontology
[?]
GO:0004418; Molecular function: hydroxymethylbilane synthase activity.
case <Property:PHOTOSYN>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.
Cross-references
[?]
Pfam | PF01379; Porphobil_deam; 1; |
PRINTS | PR00151; PORPHBDMNASE; 1; |
TIGRFAMs | TIGR00212; HemC; 1; |
PROSITE | PS00533; PORPHOBILINOGEN_DEAM; 1; |
Features
[?]
From: HEM3_ECOLI (P06983) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 242 | 242 | S-(dipyrrolylmethanemethyl)cysteine | C |
Additional information
[?]
Size range | 282-395 amino acids |
Related rules | None |
Fusion | None |
Comments | Chlamydial hemC are divergent and lack the cofactor binding site, they are shorter and they have not been included in the alignment. HALSA and PAEMA have atypical inserts. RPE1 type insert in RICCN. |