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HAMAP rule MF_00260

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General rule information [?]

Accession MF_00260
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 39)
Name Porphobil_deam
Scope
Bacteria
Archaea
Template P06983 (HEM3_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HEM3
case <OC:Bacteria>
Protein name
RecName: Full=Porphobilinogen deaminase;
Short=PBG;
EC 2.5.1.61;
AltName: Full=Hydroxymethylbilane synthase;
Short=HMBS;
AltName: Full=Pre-uroporphyrinogen synthase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable porphobilinogen deaminase;
Short=PBG;
EC 2.5.1.61;
AltName: Full=Hydroxymethylbilane synthase;
Short=HMBS;
AltName: Full=Pre-uroporphyrinogen synthase;
end case
Gene name
hemC

Comments [?]

Function Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Catalytic activity RHEA:13185: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)
EC 2.5.1.61
Cofactor dipyrromethane
Note: Binds 1 dipyrromethane group covalently.
case not <Property:PHOTOSYN>
Pathway Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
end case
case <Property:PHOTOSYN>
Pathway Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
Porphyrin-containing compound metabolism; chlorophyll biosynthesis.
end case
case <OC:Bacteria>
Subunit Monomer.
end case
Miscellaneous The porphobilinogen subunits are added to the dipyrromethane group.
Similarity Belongs to the HMBS family.

Keywords [?]

Porphyrin biosynthesis
case <Property:PHOTOSYN>
Chlorophyll biosynthesis
end case
Transferase

Gene Ontology [?]

GO:0004418; Molecular function: hydroxymethylbilane synthase activity.
case <Property:PHOTOSYN>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case
GO:0006779; Biological process: porphyrin-containing compound biosynthetic process.

Cross-references [?]

Pfam PF01379; Porphobil_deam; 1;
PRINTS PR00151; PORPHBDMNASE; 1;
TIGRFAMs TIGR00212; HemC; 1;
PROSITE PS00533; PORPHOBILINOGEN_DEAM; 1;

Features [?]

From: HEM3_ECOLI (P06983)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     242     242       S-(dipyrrolylmethanemethyl)cysteine     C  

Additional information [?]

Size range 282-395 amino acids
Related rules None
Fusion None
Comments Chlamydial hemC are divergent and lack the cofactor binding site, they are shorter and they have not been included in the alignment. HALSA and PAEMA have atypical inserts. RPE1 type insert in RICCN.


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