HAMAP rule MF_00260
General rule information
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| Accession | MF_00260 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 40) |
| Name | Porphobil_deam |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P06983 (HEM3_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00260 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HEM3 |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Porphobilinogen deaminase; Short=PBG; EC=2.5.1.61; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Probable porphobilinogen deaminase; Short=PBG; EC=2.5.1.61; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; AltName: Full=Pre-uroporphyrinogen synthase; |
| end case | |
| Gene name | Name=hemC; |
Comments
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| FUNCTION | Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. |
| CATALYTIC ACTIVITY | Reaction=H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+); Xref=Rhea:RHEA:13185, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:57845, ChEBI:CHEBI:58126; EC=2.5.1.61; |
| COFACTOR | Name=dipyrromethane; Xref=ChEBI:CHEBI:60342; Note=Binds 1 dipyrromethane group covalently.; |
| case not <Property:PHOTOSYN> | |
| PATHWAY | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. |
| end case | |
| case <Property:PHOTOSYN> | |
| PATHWAY | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. |
| PATHWAY | Porphyrin-containing compound metabolism; chlorophyll biosynthesis. |
| end case | |
| case <OC:Bacteria> | |
| SUBUNIT | Monomer. |
| end case | |
| MISCELLANEOUS | The porphobilinogen subunits are added to the dipyrromethane group. |
| SIMILARITY | Belongs to the HMBS family. |
Keywords
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| Porphyrin biosynthesis | |
| case <Property:PHOTOSYN> | |
| Chlorophyll biosynthesis | |
| end case | |
| Transferase | |
Gene Ontology
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| GO:0004418; Molecular function:hydroxymethylbilane synthase activity | |
| case <Property:PHOTOSYN> | |
| GO:0015995; Biological process:chlorophyll biosynthetic process | |
| end case | |
| GO:0006779; Biological process:porphyrin-containing compound biosynthetic process | |
Cross-references
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| Pfam | PF01379; Porphobil_deam; 1; |
| PRINTS | PR00151; PORPHBDMNASE; 1; |
| NCBIfam | TIGR00212; HemC; 1; |
| PROSITE | PS00533; PORPHOBILINOGEN_DEAM; 1; |
Features
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| From: HEM3_ECOLI (P06983) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 242 | 242 | /note="S-(dipyrrolylmethanemethyl)cysteine" | C | ||||||||
Additional information
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| Size range | 282-395 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Chlamydial hemC are divergent and lack the cofactor binding site, they are shorter and they have not been included in the alignment. HALSA and PAEMA have atypical inserts. RPE1 type insert in RICCN. |