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HAMAP rule MF_00265

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General rule information [?]

Accession MF_00265
Dates 1-JUN-2001 (Created)
19-NOV-2022 (Last updated, Version 32)
Name VapC/Nob1
Scope(s) Bacteria
Archaea
Template(s) Q8ZM86 (VAPC_SALTY); O06662 (VAPC_SHIFL); P9WFB7 (VAPC3_MYCTU); P9WF85 (VPC25_MYCTU); P9WFB9 (VAPC2_MYCTU); O58440 (NOB1_PYRHO); [ Recover all ]
Triggered by HAMAP; MF_00265 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Identifier VAPC
Protein name RecName: Full=tRNA(fMet)-specific endonuclease VapC;
                 EC=3.1.-.-;
AltName: Full=RNase VapC;
AltName: Full=Toxin VapC;
Gene name Name=vapC;
else case <OC:Bacteria>
Identifier VAPC
Protein name RecName: Full=Ribonuclease VapC;
                 Short=RNase VapC;
                 EC=3.1.-.-;
AltName: Full=Toxin VapC;
Gene name Name=vapC;
else case <OC:Archaea>
Identifier VAPC
Protein name RecName: Full=Ribonuclease VapC;
                 Short=RNase VapC;
                 EC=3.1.-.-;
AltName: Full=Putative toxin VapC;
Gene name Name=vapC;
end case

Comments [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
FUNCTIONToxic component of a toxin-antitoxin (TA) system. A site- specific tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Its toxic effects are neutralized by expression of cognate antitoxin VapB.
else
FUNCTIONToxic component of a toxin-antitoxin (TA) system. An RNase.
end case
case <FT:1> or <FT:2>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITYBelongs to the PINc/VapC protein family.

Keywords [?]


Gene Ontology [?]

case <FT:1> or <FT:2>
GO:0000287; Molecular function:magnesium ion binding
end case

Cross-references [?]

Pfam PF01850; PIN; 0-1;
SMART SM00670; PINc; 0-1;

Features [?]

From: VAPC1_AQUAE (O66399)
Key From To Description Tag Condition FTGroup
BINDING 9 9 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D
BINDING 102 102 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D

Additional information [?]

Size range 112-197 amino acids
Related rules None
Fusion Nter: <Leu-rich domain> Cter: <TRAM domain>
Comments VAPC1_THEAC and NOB1_METJA may be too long at N-terminus. Y540_THEAC fused with a Leu-rich transmembrane domain at N-terminus and TRAM domain at C-terminus, several other proteins are also fused to a TRAM domain. VAPC8_MYCTU atypical sequence. VAPC3_METJA, VPC14_MYCTU too short. At least 1 zinc-binding archaeal member processes pre-16S rRNA (NOB1_PYRHO, O58440); archaeal members that have the ability to bind zinc in the C-termini have been accordingly reannotated.



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