HAMAP rule MF_00290

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00290
Accession	MF_00290
Dates	28-FEB-2005 (Created) 11-FEB-2025 (Last updated, Version 21)
Name	tRNA_dimethyltr_TRM1
Scope(s)	Bacteria Archaea
Template(s)	P81554; O67010; [ Recover all ]
Triggered by	HAMAP; MF_00290 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TRM1
case <OC:Archaea>
Protein name	RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase; EC=2.1.1.216; AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase; AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase; AltName: Full=tRNA(m(2,2)G26)dimethyltransferase;
end case
case <OC:Bacteria>
Protein name	RecName: Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase; EC=2.1.1.215;
end case
Gene name	Name=trm1;

Comments [?]

case <OC:Archaea>
FUNCTION	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
CATALYTIC ACTIVITY	Reaction=guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)- dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+); Xref=Rhea:RHEA:43140, Rhea:RHEA-COMP:10359, Rhea:RHEA-COMP:10360, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.216;
end case
case <OC:Bacteria>
FUNCTION	Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
CATALYTIC ACTIVITY	Reaction=guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L- methionine = N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine + 4 H(+); Xref=Rhea:RHEA:43136, Rhea:RHEA-COMP:10353, Rhea:RHEA-COMP:10354, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.215;
end case
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

Keywords [?]

Gene Ontology [?]

GO:0160104; Molecular function:tRNA (guanine(26)-N2)-dimethyltransferase activity

GO:0030488; Biological process:tRNA methylation

Cross-references [?]

Features [?]

From: TRM1_AQUAE (O67010)

Key

From

Description

Tag

Condition

FTGroup

BINDING