HAMAP rule MF_00290
General rule information
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Accession | MF_00290 |
Dates | 1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 23) |
Name | tRNA_dimethyltr_TRM1 |
Scope | Bacteria
Archaea |
Templates | P81554 (TRM1_PYRFU); O67010 (TRM1_AQUAE): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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case <OC:Archaea>
Protein name |
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end case
case <OC:Bacteria>
Protein name |
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end case
Gene name |
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Comments
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case <OC:Archaea>
Function | Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. |
Catalytic activity | RHEA:43140: guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine
EC 2.1.1.216 |
end case
case <OC:Bacteria>
Function | Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. |
Catalytic activity | RHEA:43136: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine
EC 2.1.1.215 |
end case
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. |
Keywords
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Gene Ontology
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GO:0004809; Molecular function: tRNA (guanine-N2-)-methyltransferase activity.
GO:0030488; Biological process: tRNA methylation.
GO:0030488; Biological process: tRNA methylation.
Cross-references
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Pfam | PF02005; TRM; 1; |
NCBIfam | TIGR00308; TRM1; 1; |
PROSITE | PS51626; SAM_MT_TRM1; 1; trigger=PRU00958; |
Additional information
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Size range | 340-420 amino acids |
Related rules | None |
Fusion | None |