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Annotation rule MF_00290
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General rule information [?]

Accession MF_00290
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 22)
Name tRNA_dimethyltr_TRM1
Scope
Bacteria
Archaea
Templates P81554 (TRM1_PYRFU); O67010 (TRM1_AQUAE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRM1
case <OC:Archaea>
Protein name
RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase;
EC 2.1.1.216;
AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase;
AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase;
AltName: Full=tRNA(m(2,2)G26)dimethyltransferase;
end case
case <OC:Bacteria>
Protein name
RecName: Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase;
EC 2.1.1.215;
end case
Gene name
trm1

Comments [?]

case <OC:Archaea>
Function Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Catalytic activity RHEA:43140: guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine
EC 2.1.1.216
end case
case <OC:Bacteria>
Function Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Catalytic activity RHEA:43136: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine
EC 2.1.1.215
end case
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

Keywords [?]


Gene Ontology [?]

GO:0004809; Molecular function: tRNA (guanine-N2-)-methyltransferase activity.
GO:0030488; Biological process: tRNA methylation.

Cross-references [?]

Pfam PF02005; TRM; 1;
TIGRFAMs TIGR00308; TRM1; 1;
PROSITE PS51626; SAM_MT_TRM1; 1; trigger=PRU00958;

Additional information [?]

Size range 340-420 amino acids
Related rules None
Fusion None