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HAMAP rule MF_00290

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General rule information [?]

Accession MF_00290
Dates 1-JUN-2001 (Created)
15-DEC-2023 (Last updated, Version 24)
Name tRNA_dimethyltr_TRM1
Scope(s) Bacteria
Archaea
Template(s) P81554 (TRM1_PYRFU); O67010 (TRM1_AQUAE); [ Recover all ]
Triggered by HAMAP; MF_00290 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRM1
case <OC:Archaea>
Protein name RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase;
                 EC=2.1.1.216;
AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase;
AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase;
AltName: Full=tRNA(m(2,2)G26)dimethyltransferase;
end case
case <OC:Bacteria>
Protein name RecName: Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase;
                 EC=2.1.1.215;
end case
Gene name Name=trm1;

Comments [?]

case <OC:Archaea>
FUNCTIONDimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
CATALYTIC ACTIVITY Reaction=guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43140, Rhea:RHEA-COMP:10359, Rhea:RHEA-COMP:10360, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.216;
end case
case <OC:Bacteria>
FUNCTIONDimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
CATALYTIC ACTIVITY Reaction=guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L- methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)- dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43136, Rhea:RHEA-COMP:10353, Rhea:RHEA-COMP:10354, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.215;
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

Keywords [?]


Gene Ontology [?]

GO:0160104; Molecular function:tRNA (guanine(26)-N2)-dimethyltransferase activity
GO:0030488; Biological process:tRNA methylation

Cross-references [?]

Pfam PF02005; TRM; 1;
NCBIfam TIGR00308; TRM1; 1;
PROSITE PS51626; SAM_MT_TRM1; 1;

Features [?]


Additional information [?]

Size range 340-420 amino acids
Related rules None
Fusion Nter: None Cter: None



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