HAMAP rule MF_00290

General rule information [?]

Accession	MF_00290
Dates	1-JUN-2001 (Created) 1-JUN-2023 (Last updated, Version 23)

Name	tRNA_dimethyltr_TRM1

Scope

Bacteria

Archaea

Templates

P81554 (TRM1_PYRFU); O67010 (TRM1_AQUAE): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TRM1

case <OC:Archaea>

Protein name

RecName:		Full=tRNA (guanine(26)-N(2))-dimethyltransferase;
		EC 2.1.1.216;
AltName:		Full=tRNA 2,2-dimethylguanosine-26 methyltransferase;
AltName:		Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase;
AltName:		Full=tRNA(m(2,2)G26)dimethyltransferase;

end case

case <OC:Bacteria>

Protein name

RecName:		Full=tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase;
		EC 2.1.1.215;

end case

Gene name

trm1

Comments [?]

case <OC:Archaea>

Function	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Catalytic activity	RHEA:43140: guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine EC 2.1.1.216

end case

case <OC:Bacteria>

Function	Dimethylates the guanine residues at position 26 and 27 of one or more tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Catalytic activity	RHEA:43136: guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine EC 2.1.1.215

end case

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

Keywords [?]

Gene Ontology [?]

GO:0004809; Molecular function: tRNA (guanine-N2-)-methyltransferase activity.
GO:0030488; Biological process: tRNA methylation.

Cross-references [?]

Additional information [?]