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Annotation rule MF_00384
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General rule information [?]

Accession MF_00384
Dates 1-JUN-2001 (Created)
18-NOV-2019 (Last updated, Version 30)
Name Homoser_kinase
Scope
Bacteria
Archaea
Templates P00547 (KHSE_ECOLI); Q6M0H5 (KHSE_METMP); Q58504 (KHSE_METJA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KHSE
Protein name
RecName: Full=Homoserine kinase;
Short=HK;
Short=HSK;
EC 2.7.1.39;
Gene name
thrB

Comments [?]

Function Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
Catalytic activity RHEA:13985: ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine
EC 2.7.1.39
Pathway Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.
Subcellular location Cytoplasm.
Similarity Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004413; Molecular function: homoserine kinase activity.
GO:0009088; Biological process: threonine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF08544; GHMP_kinases_C; 1;
PF00288; GHMP_kinases_N; 1;
PIRSF PIRSF000676; Homoser_kin; 1;
PRINTS PR00958; HOMSERKINASE; 1;
TIGRFAMs TIGR00191; ThrB; 1;
PROSITE PS00627; GHMP_KINASES_ATP; 1;

Features [?]

From: KHSE_ECOLI (P00547)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     91     101       ATP     [APKR]-x(3)-G-[LFM]-G-[GS]-S-[GSA]-[STAC]  

Additional information [?]

Size range 281-324 amino acids
Related rules MF_00217 (MVK)
Fusion None
Comments Some other species have a non-classical-type thrB