HAMAP rule MF_00388
General rule information
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| Accession | MF_00388 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | LpxC |
| Scope(s) |
Bacteria Plastid |
| Template(s) | P0A725 (LPXC_ECOLI); O67648 (LPXC_AQUAE); P47205 (LPXC_PSEAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_00388 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LPXC |
| Protein name | RecName: Full=UDP-3-O-acyl-N-acetylglucosamine deacetylase; Short=UDP-3-O-acyl-GlcNAc deacetylase; EC=3.5.1.108; AltName: Full=UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase; |
| Gene name | Name=lpxC; |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. |
| end case | |
| case <OG:Chloroplast> | |
| FUNCTION | Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate; Xref=Rhea:RHEA:67816, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:137740, ChEBI:CHEBI:173225; EC=3.5.1.108; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; |
| PATHWAY | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N- acetyl-alpha-D-glucosamine: step 2/6. |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the LpxC family. |
Keywords
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Gene Ontology
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| GO:0008759; Molecular function:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity | |
| GO:0009245; Biological process:lipid A biosynthetic process | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
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Features
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| From: LPXC_ECOLI (P0A725) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 265 | 265 | /note="Proton donor" | H | ||||||||
| BINDING | 79 | 79 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 238 | 238 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 242 | 242 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
D | ||||||||
Additional information
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| Size range | 250-350 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: MF_00406 (fabZ) |