HAMAP rule MF_00388

General rule information [?]

Accession	MF_00388
Dates	1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 31)

Name

LpxC

Scope

Bacteria

Plastid

Templates

P0A725 (LPXC_ECOLI); O67648 (LPXC_AQUAE); P47205 (LPXC_PSEAE): [Recover all]

Triggered by

HAMAP; MF_00388 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

LPXC

Protein name

RecName:		Full=UDP-3-O-acyl-N-acetylglucosamine deacetylase;
		Short=UDP-3-O-acyl-GlcNAc deacetylase;
		EC 3.5.1.108;
AltName:		Full=UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase;

Gene name

lpxC

Comments [?]

case <OC:Bacteria>

Function

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

end case

case <OG:Chloroplast>

Function

Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane.

end case

Catalytic activity	RHEA:67816: a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate EC 3.5.1.108
Cofactor	Zn(2+)
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.

case <OG:Chloroplast>

Subcellular location

Plastid, chloroplast.

end case

Similarity

Belongs to the LpxC family.

Keywords [?]

Hydrolase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Metal-binding
Zinc

Gene Ontology [?]

GO:0008759; Molecular function: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

case <OG:Chloroplast>

GO:0009507; Cellular component: chloroplast.

end case

Cross-references [?]

Pfam	PF03331; LpxC; 1;
TIGRFAMs	TIGR00325; lpxC; 1;

Features [?]

From: LPXC_ECOLI (P0A725)

Key From To Description Tag Condition FTGroup

ACT_SITE 265 265 Proton donor H

BINDING 79 79 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H

BINDING 238 238 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H

BINDING 242 242 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 D

Additional information [?]

Size range	250-350 amino acids
Related rules	None
Fusion	Nter: None; Cter: MF_00406 (fabZ)

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