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Annotation rule MF_00388 |
General rule information
[?]
Accession |
MF_00388 |
Dates |
1-JUN-2001 (Created) 18-NOV-2019 (Last updated, Version 28) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=UDP-3-O-acyl-N-acetylglucosamine deacetylase;
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Short=UDP-3-O-acyl-GlcNAc deacetylase;
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EC 3.5.1.108;
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AltName:
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Full=UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase;
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case <OC:Bacteria>
Function |
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. |
end case
case <OG:Chloroplast>
Function |
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane. |
end case
Catalytic activity |
RHEA:25209: H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine
EC 3.5.1.108
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Cofactor |
Zn(2+) |
Pathway |
Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6. |
case <OG:Chloroplast>
Subcellular location |
Plastid, chloroplast. |
end case
Similarity |
Belongs to the LpxC family. |
GO:0008759; Molecular function: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
case <OG:Chloroplast>
end case
From: LPXC_ECOLI (P0A725) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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265
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265
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Proton donor
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H
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METAL
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79
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79
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Zinc; via tele nitrogen
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H
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METAL
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238
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238
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Zinc; via tele nitrogen
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H
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METAL
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242
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242
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Zinc
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D
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Additional information
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Size range |
250-350 amino acids |
Related rules |
None |
Fusion |
Nter: None; Cter: MF_00406 (fabZ) |