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Annotation rule MF_00388
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General rule information [?]

Accession MF_00388
Dates 1-JUN-2001 (Created)
14-MAY-2022 (Last updated, Version 30)
Name LpxC
Scope
Bacteria
Plastid
Templates P0A725 (LPXC_ECOLI); O67648 (LPXC_AQUAE); P47205 (LPXC_PSEAE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LPXC
Protein name
RecName: Full=UDP-3-O-acyl-N-acetylglucosamine deacetylase;
Short=UDP-3-O-acyl-GlcNAc deacetylase;
EC 3.5.1.108;
AltName: Full=UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase;
Gene name
lpxC

Comments [?]

case <OC:Bacteria>
Function Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
end case
case <OG:Chloroplast>
Function Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. The target for the lipopolysaccharides produced in the chloroplast could either be the cell envelope of the eukaryote or the plastid membrane.
end case
Catalytic activity RHEA:67816: a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate
EC 3.5.1.108
Cofactor Zn(2+)
Pathway Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the LpxC family.

Keywords [?]

Hydrolase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Metal-binding
Zinc

Gene Ontology [?]

GO:0008759; Molecular function: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF03331; LpxC; 1;
TIGRFAMs TIGR00325; lpxC; 1;

Features [?]

From: LPXC_ECOLI (P0A725)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     265     265       Proton donor     H  
BINDING     79     79       /ligand="Zn(2+)" /ligand_id="29105     H  
BINDING     238     238       /ligand="Zn(2+)" /ligand_id="29105     H  
BINDING     242     242       /ligand="Zn(2+)" /ligand_id="29105     D  

Additional information [?]

Size range 250-350 amino acids
Related rules None
Fusion Nter: None; Cter: MF_00406 (fabZ)


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