HAMAP rule MF_00394
General rule information
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| Accession | MF_00394 |
| Dates | 1-JUN-2001 (Created) 19-NOV-2022 (Last updated, Version 37) |
| Name | NAD_Glyc3P_dehydrog |
| Scope | Bacteria
Archaea |
| Template | O29390 (GPDA_ARCFU) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Catalytic activity | RHEA:11092: NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH
EC 1.1.1.94 |
| RHEA:11096: NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH
EC 1.1.1.94 |
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| Subcellular location | Cytoplasm. |
| Pathway | Membrane lipid metabolism; glycerophospholipid metabolism. |
| Similarity | Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. |
Keywords
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Cytoplasm
Lipid biosynthesis
Lipid metabolism
Phospholipid biosynthesis
Phospholipid metabolism
NAD
Oxidoreductase
Lipid biosynthesis
Lipid metabolism
Phospholipid biosynthesis
Phospholipid metabolism
NAD
Oxidoreductase
Gene Ontology
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GO:0047952; Molecular function: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity.
GO:0046167; Biological process: glycerol-3-phosphate biosynthetic process.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0046167; Biological process: glycerol-3-phosphate biosynthetic process.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF07479; NAD_Gly3P_dh_C; 1; |
| PF01210; NAD_Gly3P_dh_N; 1; | |
| PIRSF | PIRSF000114; Glycerol-3-P_dh; 1; |
| PRINTS | PR00077; GPDHDRGNASE; 1; |
| PROSITE | PS00957; NAD_G3PDH; 1; |
Features
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| From: GPDA_ECOLI (P0A6S7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 12 | 17 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | |||||||||
| BINDING | 259 | 260 | /ligand="substrate | R-N | ||||||||
| ACT_SITE | 195 | 195 | Proton acceptor | K | ||||||||
| BINDING | 110 | 110 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | K | ||||||||
| BINDING | 110 | 110 | /ligand="substrate | K | ||||||||
| BINDING | 143 | 143 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [AS] | ||||||||
| BINDING | 259 | 259 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | R | ||||||||
| BINDING | 285 | 285 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | E | ||||||||
Additional information
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| Size range | 297-369 amino acids |
| Related rules | None |
| Fusion | None |