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HAMAP rule MF_00455

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General rule information [?]

Accession MF_00455
Dates 24-SEP-2001 (Created)
1-JUN-2023 (Last updated, Version 43)
Name Xylose_isom_A
Scope
Bacteria
Templates P12851 (XYLA_ACTM4); P12070 (XYLA_ARTS7); P54272 (XYLA_BACSW); P00944 (XYLA_ECOLI); P15587 (XYLA_STROL): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
XYLA
Protein name
RecName: Full=Xylose isomerase;
EC 5.3.1.5;
Gene name
xylA

Comments [?]

Catalytic activity RHEA:22816: alpha-D-xylose = alpha-D-xylulofuranose
EC 5.3.1.5
Cofactor Mg(2+)
Note: Binds 2 magnesium ions per subunit.
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the xylose isomerase family.

Keywords [?]

Cytoplasm
Isomerase
Carbohydrate metabolism
Xylose metabolism
Magnesium
Metal-binding

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0009045; Molecular function: xylose isomerase activity.
GO:0042732; Biological process: D-xylose metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01261; AP_endonuc_2; 1;
PRINTS PR00688; XYLOSISMRASE; 1;
NCBIfam TIGR02630; Xylose_isom_A; 1;
PROSITE PS51415; XYLOSE_ISOMERASE; 1;

Features [?]

case <OC:Actinomycetales> or <OC:Deinococci>
From: XYLA_ACTM4 (P12851)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     54     54             H  
ACT_SITE     57     57             [DE]  
BINDING     181     181       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     E  
BINDING     217     217       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     E  
BINDING     217     217       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     E  
BINDING     220     220       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     H  
BINDING     245     245       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     255     255       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     257     257       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     292     292       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
end case
case not <OC:Actinomycetales> and not <OC:Deinococci>
From: XYLA_ECOLI (P00944)
ACT_SITE     101     101             H  
ACT_SITE     104     104             [DE]  
BINDING     232     232       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     E  
BINDING     268     268       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     E  
BINDING     268     268       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     E  
BINDING     271     271       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     H  
BINDING     296     296       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
BINDING     307     307       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     309     309       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2     D  
BINDING     339     339       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1     D  
end case

Additional information [?]

Size range 386-449 amino acids
Related rules None
Fusion None


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