HAMAP rule MF_00456
General rule information
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| Accession | MF_00456 |
| Dates | 26-SEP-2001 (Created)
3-SEP-2024 (Last updated, Version 42) |
| Name | ProB |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A7B5 (PROB_ECOLI); P17856 (PROB_SERMA); P96488 (PROB_STRTR); [ Recover all ] |
| Triggered by |
HAMAP; MF_00456 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PROB |
| Protein name | RecName: Full=Glutamate 5-kinase; EC=2.7.2.11; AltName: Full=Gamma-glutamyl kinase; Short=GK; |
| Gene name | Name=proB; |
Comments
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| FUNCTION | Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. |
| CATALYTIC ACTIVITY | Reaction=L-glutamate + ATP = L-glutamyl 5-phosphate + ADP; Xref=Rhea:RHEA:14877, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:58274, ChEBI:CHEBI:456216; EC=2.7.2.11; |
| PATHWAY | Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the glutamate 5-kinase family. |
Keywords
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| Amino-acid biosynthesis |
| ATP-binding |
| Cytoplasm |
| Kinase |
| Nucleotide-binding |
| Proline biosynthesis |
| Transferase |
Gene Ontology
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| GO:0004349; Molecular function:glutamate 5-kinase activity |
| GO:0055129; Biological process:L-proline biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00696; AA_kinase; 1; |
| Pfam | PF01472; PUA; 1; |
| PIRSF | PIRSF000729; GK; 1; |
| PRINTS | PR00474; GLU5KINASE; 1; |
| NCBIfam | TIGR01027; ProB; 1; |
| PROSITE | PS00902; GLUTAMATE_5_KINASE; 1; |
| PROSITE | PS50890; PUA; 0-1; |
Features
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| From: PROB_ECOLI (P0A7B5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 169 | 170 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS]-D | ||||||||
| BINDING | 211 | 217 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS]-G-G-[MI]-x-[TS]-K | ||||||||
| BINDING | 10 | 10 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 50 | 50 | /ligand="substrate" | S | ||||||||
| BINDING | 137 | 137 | /ligand="substrate" | D | ||||||||
| BINDING | 149 | 149 | /ligand="substrate" | N | ||||||||
Additional information
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| Size range | 245-470 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |