HAMAP rule MF_00456

Accession	MF_00456
Dates	26-SEP-2001 (Created) 1-JUN-2023 (Last updated, Version 40)

Name

ProB

Scope

Bacteria Archaea

Templates

P0A7B5 (PROB_ECOLI); P17856 (PROB_SERMA); P96488 (PROB_STRTR): [Recover all]

Triggered by

HAMAP; MF_00456 (Get profile general information and statistics)

Identifier

PROB

Protein name

RecName: Full=Glutamate 5-kinase; EC 2.7.2.11; AltName: Full=Gamma-glutamyl kinase; Short=GK;

Gene name

proB

Function	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
Catalytic activity	RHEA:14877: ATP + L-glutamate = ADP + L-glutamyl 5-phosphate EC 2.7.2.11
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.
Subcellular location	Cytoplasm.
Similarity	Belongs to the glutamate 5-kinase family.

Amino-acid biosynthesis
ATP-binding
Cytoplasm
Kinase
Nucleotide-binding
Proline biosynthesis
Transferase

GO:0004349; Molecular function: glutamate 5-kinase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Pfam	PF00696; AA_kinase; 1;
	PF01472; PUA; 1;
PIRSF	PIRSF000729; GK; 1;
PRINTS	PR00474; GLU5KINASE; 1;
NCBIfam	TIGR01027; ProB; 1;
PROSITE	PS00902; GLUTAMATE_5_KINASE; 1;
	PS50890; PUA; 0-1; trigger=PRU00161;

From: PROB_ECOLI (P0A7B5)

Key

From

To

Description

Tag

Condition

FTGroup

BINDING (Optional)

169

170

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

[TS]-D

BINDING (Optional)

211

217

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

[TS]-G-G-[MI]-x-[TS]-K

BINDING (Optional)

10

10

/ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

K

BINDING (Optional)

50

50

/ligand="substrate

S

BINDING (Optional)

137

137

/ligand="substrate

D

BINDING (Optional)

149

149

/ligand="substrate

N

Size range	245-470 amino acids
Related rules	None
Fusion	None

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