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Annotation rule MF_00456
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General rule information [?]

Accession MF_00456
Dates 26-SEP-2001 (Created)
21-AUG-2020 (Last updated, Version 37)
Name ProB
Scope
Bacteria
Archaea
Templates P0A7B5 (PROB_ECOLI); P17856 (PROB_SERMA); P96488 (PROB_STRTR): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PROB
Protein name
RecName: Full=Glutamate 5-kinase;
EC 2.7.2.11;
AltName: Full=Gamma-glutamyl kinase;
Short=GK;
Gene name
proB

Comments [?]

Function Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
Catalytic activity RHEA:14877: ATP + L-glutamate = ADP + L-glutamyl 5-phosphate
EC 2.7.2.11
Pathway Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.
Subcellular location Cytoplasm.
Similarity Belongs to the glutamate 5-kinase family.

Keywords [?]


Gene Ontology [?]

GO:0004349; Molecular function: glutamate 5-kinase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00696; AA_kinase; 1;
PF01472; PUA; 1;
PIRSF PIRSF000729; GK; 1;
PRINTS PR00474; GLU5KINASE; 1;
TIGRFAMs TIGR01027; ProB; 1;
PROSITE PS00902; GLUTAMATE_5_KINASE; 1;
PS50890; PUA; 0-1; trigger=PRU00161;

Features [?]

From: PROB_ECOLI (P0A7B5)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     169     170       ATP     [TS]-D  
NP_BIND (Optional)     211     217       ATP     [TS]-G-G-[MI]-x-[TS]-K  
BINDING (Optional)     10     10       ATP     K  
BINDING (Optional)     50     50       Substrate     S  
BINDING (Optional)     137     137       Substrate     D  
BINDING (Optional)     149     149       Substrate; via amide nitrogen     N  

Additional information [?]

Size range 245-470 amino acids
Related rules None
Fusion None