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HAMAP rule MF_00456

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General rule information [?]

Accession MF_00456
Dates 26-SEP-2001 (Created)
14-MAY-2024 (Last updated, Version 41)
Name ProB
Scope(s) Bacteria
Archaea
Template(s) P0A7B5 (PROB_ECOLI); P17856 (PROB_SERMA); P96488 (PROB_STRTR); [ Recover all ]
Triggered by HAMAP; MF_00456 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PROB
Protein name RecName: Full=Glutamate 5-kinase;
                 EC=2.7.2.11;
AltName: Full=Gamma-glutamyl kinase;
                 Short=GK;
Gene name Name=proB;

Comments [?]

FUNCTIONCatalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
CATALYTIC ACTIVITY Reaction=ATP + L-glutamate = ADP + L-glutamyl 5-phosphate; Xref=Rhea:RHEA:14877, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:58274, ChEBI:CHEBI:456216; EC=2.7.2.11;
PATHWAYAmino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the glutamate 5-kinase family.

Keywords [?]


Gene Ontology [?]

GO:0004349; Molecular function:glutamate 5-kinase activity
GO:0055129; Biological process:L-proline biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00696; AA_kinase; 1;
Pfam PF01472; PUA; 1;
PIRSF PIRSF000729; GK; 1;
PRINTS PR00474; GLU5KINASE; 1;
NCBIfam TIGR01027; ProB; 1;
PROSITE PS00902; GLUTAMATE_5_KINASE; 1;
PROSITE PS50890; PUA; 0-1;

Features [?]

From: PROB_ECOLI (P0A7B5)
Key From To Description Tag Condition FTGroup
BINDING 169 170 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
[TS]-D
BINDING 211 217 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
[TS]-G-G-[MI]-x-[TS]-K
BINDING 10 10 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
K
BINDING 50 50 /ligand="substrate" S
BINDING 137 137 /ligand="substrate" D
BINDING 149 149 /ligand="substrate" N

Additional information [?]

Size range 245-470 amino acids
Related rules None
Fusion Nter: None Cter: None



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