HAMAP rule MF_00456
General rule information
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Accession | MF_00456 |
Dates | 26-SEP-2001 (Created) 19-NOV-2022 (Last updated, Version 39) |
Name | ProB |
Scope | Bacteria
Archaea |
Templates | P0A7B5 (PROB_ECOLI); P17856 (PROB_SERMA); P96488 (PROB_STRTR): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. |
Catalytic activity | RHEA:14877: ATP + L-glutamate = ADP + L-glutamyl 5-phosphate
EC 2.7.2.11 |
Pathway | Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the glutamate 5-kinase family. |
Keywords
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Amino-acid biosynthesis
ATP-binding
Cytoplasm
Kinase
Nucleotide-binding
Proline biosynthesis
Transferase
ATP-binding
Cytoplasm
Kinase
Nucleotide-binding
Proline biosynthesis
Transferase
Gene Ontology
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GO:0004349; Molecular function: glutamate 5-kinase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00696; AA_kinase; 1; |
PF01472; PUA; 1; | |
PIRSF | PIRSF000729; GK; 1; |
PRINTS | PR00474; GLU5KINASE; 1; |
TIGRFAMs | TIGR01027; ProB; 1; |
PROSITE | PS00902; GLUTAMATE_5_KINASE; 1; |
PS50890; PUA; 0-1; trigger=PRU00161; |
Features
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From: PROB_ECOLI (P0A7B5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 169 | 170 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [TS]-D | ||||||||
BINDING (Optional) | 211 | 217 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [TS]-G-G-[MI]-x-[TS]-K | ||||||||
BINDING (Optional) | 10 | 10 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K | ||||||||
BINDING (Optional) | 50 | 50 | /ligand="substrate | S | ||||||||
BINDING (Optional) | 137 | 137 | /ligand="substrate | D | ||||||||
BINDING (Optional) | 149 | 149 | /ligand="substrate | N |
Additional information
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Size range | 245-470 amino acids |
Related rules | None |
Fusion | None |