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HAMAP rule MF_00473
General rule information
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| Accession | MF_00473 |
| Dates | 25-OCT-2001 (Created)
11-NOV-2021 (Last updated, Version 44) |
| Name | G6P_isomerase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A6T1 (G6PI_ECOLI); P0A0T1 (G6PI_XANCI); P28718 (G6PI_ZYMMO); Q9X1A5 (G6PI_THEMA); P9WN69 (G6PI_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00473 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | G6PI |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Glucose-6-phosphate isomerase; Short=GPI; EC=5.3.1.9; AltName: Full=Phosphoglucose isomerase; Short=PGI; AltName: Full=Phosphohexose isomerase; Short=PHI; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Probable glucose-6-phosphate isomerase; Short=GPI; EC=5.3.1.9; AltName: Full=Phosphoglucose isomerase; Short=PGI; AltName: Full=Phosphohexose isomerase; Short=PHI; |
| end case | |
| Gene name | Name=pgi; |
Comments
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| FUNCTION | Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. |
| CATALYTIC ACTIVITY | Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate; Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225; EC=5.3.1.9; |
| PATHWAY | Carbohydrate biosynthesis; gluconeogenesis. |
| PATHWAY | Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the GPI family. |
Keywords
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| case <FT:4> or <FT:5> or <FT:6> | |
| Acetylation | |
| end case | |
| Cytoplasm | |
| Isomerase | |
| Gluconeogenesis | |
| Glycolysis | |
| case <FT:7> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0004347; Molecular function:glucose-6-phosphate isomerase activity |
| GO:0006094; Biological process:gluconeogenesis |
| GO:0006096; Biological process:glycolytic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00342; PGI; 1; |
| PRINTS | PR00662; G6PISOMERASE; 1; |
| PROSITE | PS00765; P_GLUCOSE_ISOMERASE_1; 1; |
| PROSITE | PS00174; P_GLUCOSE_ISOMERASE_2; 1; |
| PROSITE | PS51463; P_GLUCOSE_ISOMERASE_3; 1; |
Features
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| From: G6PI_ECOLI (P0A6T1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 355 | 355 | /note="Proton donor" | E | ||||||||
| ACT_SITE | 386 | 386 | H | |||||||||
| ACT_SITE | 514 | 514 | K | |||||||||
| case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
| MOD_RES | 80 | 80 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 228 | 228 | /note="N6-acetyllysine" | K | ||||||||
| MOD_RES | 234 | 234 | /note="N6-acetyllysine" | K | ||||||||
| end case | ||||||||||||
| From: G6PI_BACSU (P80860) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacillaceae> | ||||||||||||
| MOD_RES | 38 | 38 | /note="Phosphothreonine" | T | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 401-562 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |