HAMAP rule MF_00473
General rule information
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Accession | MF_00473 |
Dates | 25-OCT-2001 (Created) 11-NOV-2021 (Last updated, Version 44) |
Name | G6P_isomerase |
Scope | Bacteria
Archaea |
Templates | P0A6T1 (G6PI_ECOLI); P0A0T1 (G6PI_XANCI); P28718 (G6PI_ZYMMO); Q9X1A5 (G6PI_THEMA); P9WN69 (G6PI_MYCTU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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case <OC:Bacteria>
Protein name |
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end case
case <OC:Archaea>
Protein name |
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end case
Gene name |
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Comments
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Function | Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. |
Catalytic activity | RHEA:11816: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate
EC 5.3.1.9 |
Pathway | Carbohydrate biosynthesis; gluconeogenesis. |
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. | |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the GPI family. |
Keywords
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case <FT:4> or <FT:5> or <FT:6>
end case
case <FT:7>
end case
Gene Ontology
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GO:0004347; Molecular function: glucose-6-phosphate isomerase activity.
GO:0006094; Biological process: gluconeogenesis.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.
GO:0006094; Biological process: gluconeogenesis.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF00342; PGI; 1; |
PRINTS | PR00662; G6PISOMERASE; 1; |
PROSITE | PS00765; P_GLUCOSE_ISOMERASE_1; 1; |
PS00174; P_GLUCOSE_ISOMERASE_2; 1; | |
PS51463; P_GLUCOSE_ISOMERASE_3; 1; |
Features
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From: G6PI_ECOLI (P0A6T1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 355 | 355 | Proton donor | E | ||||||||
ACT_SITE | 386 | 386 | H | |||||||||
ACT_SITE | 514 | 514 | K |
case <OC:Escherichia> or <OC:Shigella>
end case
case <OC:Bacillaceae>
From: G6PI_BACSU (P80860) | ||||||||||||
MOD_RES | 38 | 38 | Phosphothreonine | T |
end case
Additional information
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Size range | 401-562 amino acids |
Related rules | None |
Fusion | None |