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Annotation rule MF_00473
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General rule information [?]

Accession MF_00473
Dates 25-OCT-2001 (Created)
22-APR-2021 (Last updated, Version 43)
Name G6P_isomerase
Scope
Bacteria
Archaea
Templates P0A6T1 (G6PI_ECOLI); P0A0T1 (G6PI_XANCI); P28718 (G6PI_ZYMMO); Q9X1A5 (G6PI_THEMA); P9WN69 (G6PI_MYCTU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
G6PI
case <OC:Bacteria>
Protein name
RecName: Full=Glucose-6-phosphate isomerase;
Short=GPI;
EC 5.3.1.9;
AltName: Full=Phosphoglucose isomerase;
Short=PGI;
AltName: Full=Phosphohexose isomerase;
Short=PHI;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable glucose-6-phosphate isomerase;
Short=GPI;
EC 5.3.1.9;
AltName: Full=Phosphoglucose isomerase;
Short=PGI;
AltName: Full=Phosphohexose isomerase;
Short=PHI;
end case
Gene name
pgi

Comments [?]

Function Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Catalytic activity RHEA:11816: aldehydo-D-glucose 6-phosphate = keto-D-fructose 6-phosphate
EC 5.3.1.9
Pathway Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subcellular location Cytoplasm.
Similarity Belongs to the GPI family.

Keywords [?]

case <FT:4> or <FT:5> or <FT:6>
Acetylation
end case
Cytoplasm
Isomerase
Gluconeogenesis
Glycolysis
case <FT:7>
Phosphoprotein
end case

Gene Ontology [?]

GO:0004347; Molecular function: glucose-6-phosphate isomerase activity.
GO:0006094; Biological process: gluconeogenesis.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00342; PGI; 1;
PRINTS PR00662; G6PISOMERASE; 1;
PROSITE PS00765; P_GLUCOSE_ISOMERASE_1; 1;
PS00174; P_GLUCOSE_ISOMERASE_2; 1;
PS51463; P_GLUCOSE_ISOMERASE_3; 1;

Features [?]

From: G6PI_ECOLI (P0A6T1)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     355     355       Proton donor     E  
ACT_SITE     386     386             H  
ACT_SITE     514     514             K  
case <OC:Escherichia> or <OC:Shigella>
MOD_RES     80     80       N6-acetyllysine     K  
MOD_RES     228     228       N6-acetyllysine     K  
MOD_RES     234     234       N6-acetyllysine     K  
end case
case <OC:Bacillaceae>
From: G6PI_BACSU (P80860)
MOD_RES     38     38       Phosphothreonine     T  
end case

Additional information [?]

Size range 401-562 amino acids
Related rules None
Fusion None


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