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HAMAP rule MF_00476

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General rule information [?]

Accession MF_00476
Dates 26-OCT-2001 (Created)
19-NOV-2022 (Last updated, Version 36)
Name NikR
Scope
Bacteria
Archaea
Template P0A6Z6 (NIKR_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NIKR
case <OC:Enterobacterales>
Protein name
RecName: Full=Nickel-responsive regulator;
Gene name
nikR
else
Protein name
RecName: Full=Putative nickel-responsive regulator;
end case

Comments [?]

case <OC:Enterobacterales>
Function Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
else
Function Transcriptional regulator.
end case
case <FTGroup:1>
Cofactor Ni(2+)
Note: Binds 1 nickel ion per subunit.
end case
case <OC:Enterobacterales>
Subunit Homotetramer.
end case
Similarity Belongs to the transcriptional regulatory CopG/NikR family.

Keywords [?]

case <OC:Enterobacterales>
Repressor
end case
Transcription
Transcription regulation
DNA-binding
case <FTGroup:1>
Nickel
Metal-binding
end case

Gene Ontology [?]

GO:0016151; Molecular function: nickel cation binding.
GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0006355; Biological process: regulation of DNA-templated transcription.

Cross-references [?]

Pfam PF08753; NikR_C; 1;
PF01402; RHH_1; 1;
TIGRFAMs TIGR02793; NikR; 1;

Features [?]

From: NIKR_ECOLI (P0A6Z6)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     76     76       /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786     H   1
BINDING     87     87       /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786     H   1
BINDING     89     89       /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786     H   1
BINDING     95     95       /ligand="Ni(2+)" /ligand_id="ChEBI:CHEBI:49786     C   1

Additional information [?]

Size range 127-148 amino acids
Related rules None
Fusion None


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