HAMAP rule MF_00476

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00476
Accession	MF_00476
Dates	28-FEB-2005 (Created) 01-JUN-2023 (Last updated, Version 27)
Name	NikR
Scope(s)	Bacteria Archaea
Template(s)	P0A6Z6; [ Recover all ]
Triggered by	HAMAP; MF_00476 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NIKR
case <OC:Enterobacterales>
Protein name	RecName: Full=Nickel-responsive regulator;
Gene name	Name=nikR;
else
Protein name	RecName: Full=Putative nickel-responsive regulator;
end case

Comments [?]

case <OC:Enterobacterales>
FUNCTION	Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
else
FUNCTION	Transcriptional regulator.
end case
case <FTGroup:1>
COFACTOR	Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Note=Binds 1 nickel ion per subunit.;
end case
case <OC:Enterobacterales>
SUBUNIT	Homotetramer.
end case
SIMILARITY	Belongs to the transcriptional regulatory CopG/NikR family.

Keywords [?]

Gene Ontology [?]

GO:0016151; Molecular function:nickel cation binding

GO:0003700; Molecular function:DNA-binding transcription factor activity

GO:0006355; Biological process:regulation of DNA-templated transcription

Cross-references [?]

Features [?]

From: NIKR_ECOLI (P0A6Z6)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"

BINDING

/ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"

BINDING

/ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"

BINDING

/ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"

Additional information [?]