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HAMAP rule MF_00476

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General rule information [?]

Accession MF_00476
Dates 26-OCT-2001 (Created)
1-JUN-2023 (Last updated, Version 37)
Name NikR
Scope(s) Bacteria
Archaea
Template(s) P0A6Z6 (NIKR_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00476 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NIKR
case <OC:Enterobacterales>
Protein name RecName: Full=Nickel-responsive regulator;
Gene name Name=nikR;
else
Protein name RecName: Full=Putative nickel-responsive regulator;
end case

Comments [?]

case <OC:Enterobacterales>
FUNCTIONTranscriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
else
FUNCTIONTranscriptional regulator.
end case
case <FTGroup:1>
COFACTOR Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Note=Binds 1 nickel ion per subunit.;
end case
case <OC:Enterobacterales>
SUBUNITHomotetramer.
end case
SIMILARITYBelongs to the transcriptional regulatory CopG/NikR family.

Keywords [?]

case <OC:Enterobacterales>
Repressor
end case
Transcription
Transcription regulation
DNA-binding
case <FTGroup:1>
Nickel
Metal-binding
end case

Gene Ontology [?]

GO:0016151; Molecular function:nickel cation binding
GO:0003700; Molecular function:DNA-binding transcription factor activity
GO:0006355; Biological process:regulation of DNA-templated transcription

Cross-references [?]

Pfam PF08753; NikR_C; 1;
Pfam PF01402; RHH_1; 1;
NCBIfam TIGR02793; NikR; 1;

Features [?]

From: NIKR_ECOLI (P0A6Z6)
Key From To Description Tag Condition FTGroup
BINDING 76 76 /ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"
H 1
BINDING 87 87 /ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"
H 1
BINDING 89 89 /ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"
H 1
BINDING 95 95 /ligand="Ni(2+)"
/ligand_id="ChEBI:CHEBI:49786"
C 1

Additional information [?]

Size range 127-148 amino acids
Related rules None
Fusion Nter: None Cter: None



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