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Annotation rule MF_00504
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General rule information [?]

Accession MF_00504
Dates 3-DEC-2001 (Created)
18-NOV-2019 (Last updated, Version 29)
Name Aminopeptidase_M17
Scope
Bacteria
Templates P37095 (PEPB_ECOLI); Q9RF52 (PEPB_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PEPB
Protein name
RecName: Full=Peptidase B;
EC 3.4.11.23;
AltName: Full=Aminopeptidase B;
Gene name
pepB

Comments [?]

Function Probably plays an important role in intracellular peptide degradation.
Catalytic activity Reaction=Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.; EC=3.4.11.23;
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
Subunit Homohexamer.
Subcellular location Cytoplasm.
Similarity Belongs to the peptidase M17 family.

Keywords [?]

Cytoplasm
Hydrolase
Protease
Aminopeptidase
Manganese
Metal-binding

Gene Ontology [?]

GO:0004177; Molecular function: aminopeptidase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0006508; Biological process: proteolysis.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00883; Peptidase_M17; 1;
PRINTS PR00481; LAMNOPPTDASE; 1;
PROSITE PS00631; CYTOSOL_AP; 1;

Features [?]

From: PEPB_ECOLI (P37095)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     207     207             K  
ACT_SITE     281     281             R  
METAL     195     195       Manganese 2     K  
METAL     200     200       Manganese 1     D  
METAL     200     200       Manganese 2     D  
METAL     218     218       Manganese 2     D  
METAL     277     277       Manganese 1     D  
METAL     279     279       Manganese 1     E  
METAL     279     279       Manganese 2     E  

Additional information [?]

Size range 427-456 amino acids
Related rules MF_00181 (AMPA)
Fusion None


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