HAMAP rule MF_00504

General rule information [?]

Accession	MF_00504
Dates	3-DEC-2001 (Created) 19-NOV-2022 (Last updated, Version 31)

Name	Aminopeptidase_M17

Scope

Bacteria

Templates

P37095 (PEPB_ECOLI); Q9RF52 (PEPB_SALTY): [Recover all]

Triggered by

HAMAP; MF_00504 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PEPB

Protein name

RecName:		Full=Peptidase B;
		EC 3.4.11.23;
AltName:		Full=Aminopeptidase B;

Gene name

pepB

Comments [?]

Function	Probably plays an important role in intracellular peptide degradation.
Catalytic activity	Reaction=Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln.; EC=3.4.11.23;
Cofactor	Mn(2+) Note: Binds 2 manganese ions per subunit.
Subunit	Homohexamer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the peptidase M17 family.

Keywords [?]

Cytoplasm
Hydrolase
Protease
Aminopeptidase
Manganese
Metal-binding

Gene Ontology [?]

GO:0004177; Molecular function: aminopeptidase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0006508; Biological process: proteolysis.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00883; Peptidase_M17; 1;
PRINTS	PR00481; LAMNOPPTDASE; 1;
PROSITE	PS00631; CYTOSOL_AP; 1;

Features [?]

From: PEPB_ECOLI (P37095)

Key From To Description Tag Condition FTGroup

ACT_SITE 207 207 K

ACT_SITE 281 281 R

BINDING 195 195 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 K

BINDING 200 200 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 D

BINDING 200 200 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 D

BINDING 218 218 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 D

BINDING 277 277 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 D

BINDING 279 279 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 E

BINDING 279 279 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 E

Additional information [?]

Size range	427-456 amino acids
Related rules	MF_00181 (AMPA)
Fusion	None

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