HAMAP rule MF_00550
General rule information
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| Accession | MF_00550 |
| Dates | 26-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 35) |
| Name | Aminopeptidase_M20 |
| Scope(s) |
Bacteria |
| Template(s) | P26311 (PEPT_SALTY); P55179 (PEPT_BACSU); P29745 (PEPT_ECOLI); P0C2T7 (PEPT_LACLC); Q9L4G1 (PEPT_LACHE); P81207 (PEPT_FUSNP); Q76HM7 (PEPT2_LACLC); Q76HM5 (PEPT_LACLL); Q84BV2 (PEPT_LACLH); [ Recover all ] |
| Triggered by |
HAMAP; MF_00550 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PEPT |
| Protein name | RecName: Full=Peptidase T; EC=3.4.11.4; AltName: Full=Aminotripeptidase; Short=Tripeptidase; AltName: Full=Tripeptide aminopeptidase; |
| Gene name | Name=pepT; |
Comments
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| FUNCTION | Cleaves the N-terminal amino acid of tripeptides. |
| CATALYTIC ACTIVITY | Reaction=Release of the N-terminal residue from a tripeptide.; EC=3.4.11.4; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the peptidase M20B family. |
Keywords
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Gene Ontology
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| GO:0045148; Molecular function:tripeptide aminopeptidase activity |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0006508; Biological process:proteolysis |
| GO:0043171; Biological process:peptide catabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS00758; ARGE_DAPE_CPG2_1; 1; |
| PROSITE | PS00759; ARGE_DAPE_CPG2_2; 1; |
| Pfam | PF07687; M20_dimer; 1; |
| Pfam | PF01546; Peptidase_M20; 1; |
| NCBIfam | TIGR01882; Peptidase-T; 1; |
Features
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| From: PEPT_SALTY (P26311) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 80 | 80 | D | |||||||||
| ACT_SITE | 173 | 173 | /note="Proton acceptor" | E | ||||||||
| BINDING | 78 | 78 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 140 | 140 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
D | ||||||||
| BINDING | 140 | 140 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
D | ||||||||
| BINDING | 174 | 174 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
E | ||||||||
| BINDING | 196 | 196 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
D | ||||||||
| BINDING | 379 | 379 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H | ||||||||
Additional information
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| Size range | 406-413 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |