HAMAP rule MF_00569
General rule information
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| Accession | MF_00569 |
| Dates | 2-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 36) |
| Name | NadA_type3 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q9KWZ1 (NADA_BACSU); O57767 (NADA_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00569 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NADA |
| Protein name | RecName: Full=Quinolinate synthase; EC=2.5.1.72; |
| Gene name | Name=nadA; |
Comments
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| FUNCTION | Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. |
| CATALYTIC ACTIVITY | Reaction=dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate; Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25889; |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; |
| PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the quinolinate synthase family. Type 3 subfamily. |
Keywords
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Gene Ontology
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| GO:0008987; Molecular function:quinolinate synthetase A activity |
| GO:0009435; Biological process:NAD biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: NADA_BACSU (Q9KWZ1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 141 | 143 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
Y-x-N | ||||||||
| BINDING | 256 | 258 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H-P-E | ||||||||
| BINDING | 110 | 110 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 230 | 230 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 320 | 320 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 46 | 46 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H | ||||||||
| BINDING | 63 | 63 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
| BINDING | 162 | 162 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
| BINDING | 273 | 273 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
T | ||||||||
Additional information
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| Size range | 336-394 amino acids |
| Related rules |
MF_00567 MF_00568 |
| Fusion | Nter: None Cter: None |