HAMAP rule MF_00569
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_00569 |
| Accession | MF_00569 |
| Dates | 28-FEB-2005 (Created)
12-JUN-2025 (Last updated, Version 31) |
| Name | NadA_type3 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q9KWZ1; O57767; [ Recover all ] |
| Triggered by |
HAMAP; MF_00569 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | NADA |
| Protein name | RecName: Full=Quinolinate synthase; EC=2.5.1.72; |
| Gene name | Name=nadA; |
Comments
[?]
| FUNCTION | Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. |
| CATALYTIC ACTIVITY | Reaction=iminosuccinate + dihydroxyacetone phosphate = quinolinate + phosphate + 2 H2O + H(+); Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25889; |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; |
| PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the quinolinate synthase family. Type 3 subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0008987; Molecular function:quinolinate synthetase A activity |
| GO:0009435; Biological process:NAD+ biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
Features
[?]
| From: NADA_BACSU (Q9KWZ1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 141 | 143 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
Y-x-N | ||||||||
| BINDING | 256 | 258 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H-P-E | ||||||||
| BINDING | 110 | 110 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 230 | 230 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 320 | 320 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 46 | 46 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H | ||||||||
| BINDING | 63 | 63 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
| BINDING | 162 | 162 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
| BINDING | 273 | 273 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
T | ||||||||
Additional information
[?]
| Size range | 336-394 amino acids |
| Related rules |
MF_00567 MF_00568 |
| Fusion | Nter: None Cter: None |