HAMAP rule MF_00577

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00577
Accession	MF_00577
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 24)
Name	HutU
Scope(s)	Bacteria Archaea
Template(s)	P25080; P25503; [ Recover all ]
Triggered by	HAMAP; MF_00577 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HUTU
case <OC:Bacteria>
Protein name	RecName: Full=Urocanate hydratase; Short=Urocanase; EC=4.2.1.49; AltName: Full=Imidazolonepropionate hydrolase;
end case
case <OC:Archaea>
Protein name	RecName: Full=Probable urocanate hydratase; Short=Urocanase; EC=4.2.1.49; AltName: Full=Imidazolonepropionate hydrolase;
end case
Gene name	Name=hutU;

Comments [?]

FUNCTION	Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
CATALYTIC ACTIVITY	Reaction=4-imidazolone-5-propanoate = trans-urocanate + H2O; Xref=Rhea:RHEA:13101, ChEBI:CHEBI:15377, ChEBI:CHEBI:17771, ChEBI:CHEBI:77893; EC=4.2.1.49;
COFACTOR	Name=NAD(+); Xref=ChEBI:CHEBI:57540; Note=Binds 1 NAD(+) per subunit.;
PATHWAY	Amino-acid degradation; L-histidine degradation into L- glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the urocanase family.

Keywords [?]

Gene Ontology [?]

GO:0016153; Molecular function:urocanate hydratase activity

GO:0006548; Biological process:L-histidine catabolic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: HUTU_BACSU (P25503)

Key

From

Description

Tag

Condition

FTGroup

BINDING