Home  |  Contact
Annotation rule MF_00577
Send feedback

General rule information [?]

Accession MF_00577
Dates 5-AUG-2002 (Created)
18-NOV-2019 (Last updated, Version 25)
Name HutU
Scope
Bacteria
Archaea
Templates P25080 (HUTU_PSEPU); P25503 (HUTU_BACSU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HUTU
case <OC:Bacteria>
Protein name
RecName: Full=Urocanate hydratase;
Short=Urocanase;
EC 4.2.1.49;
AltName: Full=Imidazolonepropionate hydrolase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Probable urocanate hydratase;
Short=Urocanase;
EC 4.2.1.49;
AltName: Full=Imidazolonepropionate hydrolase;
end case
Gene name
hutU

Comments [?]

Function Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalytic activity RHEA:13101: 4-imidazolone-5-propanoate = H2O + trans-urocanate
EC 4.2.1.49
Cofactor NAD(+)
Note: Binds 1 NAD(+) per subunit.
Pathway Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
Subcellular location Cytoplasm.
Similarity Belongs to the urocanase family.

Keywords [?]


Gene Ontology [?]

GO:0016153; Molecular function: urocanate hydratase activity.
GO:0006548; Biological process: histidine catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01175; Urocanase; 1;
PF17392; Urocanase_C; 1;
PF17391; Urocanase_N; 1;
PIRSF PIRSF001423; Urocanate_hydrat; 1;
TIGRFAMs TIGR01228; hutU; 1;
PROSITE PS01233; UROCANASE; 1;

Features [?]

From: HUTU_BACSU (P25503)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     49     50       NAD     G-G  
NP_BIND (Optional)     173     175       NAD     G-M-G  
NP_BIND (Optional)     239     240       NAD     N-A  
NP_BIND (Optional)     260     264       NAD     Q-T-[SA]-A-H  
NP_BIND (Optional)     270     271       NAD     [YF]-[VIL]  
ACT_SITE     407     407             C  
BINDING (Optional)     127     127       NAD     Q  
BINDING (Optional)     193     193       NAD     [ED]  
BINDING (Optional)     198     198       NAD     R  
BINDING (Optional)     319     319       NAD; via carbonyl oxygen     Y  
BINDING (Optional)     489     489       NAD; via carbonyl oxygen     G  

Additional information [?]

Size range 520-680 amino acids
Related rules None
Fusion None