HAMAP rule MF_00577

General rule information [?]

Accession	MF_00577
Dates	5-AUG-2002 (Created) 1-JUN-2023 (Last updated, Version 28)

Name

HutU

Scope

Bacteria

Archaea

Templates

P25080 (HUTU_PSEPU); P25503 (HUTU_BACSU): [Recover all]

Triggered by

HAMAP; MF_00577 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HUTU

case <OC:Bacteria>

Protein name

RecName:		Full=Urocanate hydratase;
		Short=Urocanase;
		EC 4.2.1.49;
AltName:		Full=Imidazolonepropionate hydrolase;

end case

case <OC:Archaea>

Protein name

RecName:		Full=Probable urocanate hydratase;
		Short=Urocanase;
		EC 4.2.1.49;
AltName:		Full=Imidazolonepropionate hydrolase;

end case

Gene name

hutU

Comments [?]

Function	Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalytic activity	RHEA:13101: 4-imidazolone-5-propanoate = H2O + trans-urocanate EC 4.2.1.49
Cofactor	NAD(+) Note: Binds 1 NAD(+) per subunit.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
Subcellular location	Cytoplasm.
Similarity	Belongs to the urocanase family.

Keywords [?]

Cytoplasm
Histidine metabolism
Lyase
NAD

Gene Ontology [?]

GO:0016153; Molecular function: urocanate hydratase activity.
GO:0006548; Biological process: histidine catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01175; Urocanase; 1;
	PF17392; Urocanase_C; 1;
	PF17391; Urocanase_N; 1;
PIRSF	PIRSF001423; Urocanate_hydrat; 1;
NCBIfam	TIGR01228; hutU; 1;
PROSITE	PS01233; UROCANASE; 1;

Features [?]

From: HUTU_BACSU (P25503)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 49 50 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 G-G

BINDING (Optional) 173 175 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 G-M-G

BINDING (Optional) 239 240 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 N-A

BINDING (Optional) 260 264 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 Q-T-[SA]-A-H

BINDING (Optional) 270 271 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [YF]-[VIL]

ACT_SITE 407 407 C

BINDING (Optional) 127 127 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 Q

BINDING (Optional) 193 193 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [ED]

BINDING (Optional) 198 198 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 R

BINDING (Optional) 319 319 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 Y

BINDING (Optional) 489 489 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 G

Additional information [?]

Size range	520-680 amino acids
Related rules	None
Fusion	None

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