HAMAP rule MF_00607
General rule information
[?]
Accession | MF_00607 |
Dates | 9-DEC-2002 (Created)
1-JUN-2023 (Last updated, Version 26) |
Name | 16SrRNA_methyltr_A |
Scope(s) |
Bacteria Archaea |
Template(s) | P06992 (RSMA_ECOLI); P13956 (ERM_BACIU); [ Recover all ] |
Triggered by |
HAMAP; MF_00607 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | RSMA |
case <OC:Bacteria> | |
Protein name | RecName: Full=Ribosomal RNA small subunit methyltransferase A; EC=2.1.1.182; AltName: Full=16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; AltName: Full=16S rRNA dimethyladenosine transferase; AltName: Full=16S rRNA dimethylase; AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase; |
else case <OC:Archaea> | |
Protein name | RecName: Full=Probable ribosomal RNA small subunit methyltransferase A; EC=2.1.1.-; AltName: Full=16S rRNA dimethyladenosine transferase; AltName: Full=16S rRNA dimethylase; AltName: Full=S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; |
end case | |
Gene name | Name=rsmA; Synonyms=ksgA; |
Comments
[?]
case <OC:Bacteria> | |
FUNCTION | Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. |
CATALYTIC ACTIVITY | Reaction=adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L- methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)- dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:19609, Rhea:RHEA-COMP:10232, Rhea:RHEA-COMP:10233, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74493; EC=2.1.1.182; |
else case <OC:Archaea> | |
FUNCTION | Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0016433; Molecular function:rRNA (adenine) methyltransferase activity |
GO:0000154; Biological process:rRNA modification |
GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
Features
[?]
From: RSMA_ECOLI (P06992) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 18 | 18 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[NH] | ||||||||
BINDING | 20 | 20 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ILVM] | ||||||||
BINDING | 45 | 45 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
BINDING | 66 | 66 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
E | ||||||||
BINDING | 91 | 91 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
BINDING | 113 | 113 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
N |
Additional information
[?]
Size range | 219-390 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |