HAMAP rule MF_00607
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00607 |
| Accession | MF_00607 |
| Dates | 9-DEC-2002 (Created)
2-SEP-2024 (Last updated, Version 27) |
| Name | 16SrRNA_methyltr_A |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P06992 (RSMA_ECOLI); P13956 (ERM_BACIU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00607 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RSMA |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Ribosomal RNA small subunit methyltransferase A; EC=2.1.1.182; AltName: Full=16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; AltName: Full=16S rRNA dimethyladenosine transferase; AltName: Full=16S rRNA dimethylase; AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase; |
| else case <OC:Archaea> | |
| Protein name | RecName: Full=Probable ribosomal RNA small subunit methyltransferase A; EC=2.1.1.-; AltName: Full=16S rRNA dimethyladenosine transferase; AltName: Full=16S rRNA dimethylase; AltName: Full=S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase; |
| end case | |
| Gene name | Name=rsmA; Synonyms=ksgA; |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. |
| CATALYTIC ACTIVITY | Reaction=adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L- methionine = N(6)-dimethyladenosine(1518)/N(6)- dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+); Xref=Rhea:RHEA:19609, Rhea:RHEA-COMP:10232, Rhea:RHEA- COMP:10233, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74493; EC=2.1.1.182; |
| else case <OC:Archaea> | |
| FUNCTION | Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. |
Keywords
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Gene Ontology
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| GO:0016433; Molecular function:rRNA (adenine) methyltransferase activity |
| GO:0000154; Biological process:rRNA modification |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: RSMA_ECOLI (P06992) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 18 | 18 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[NH] | ||||||||
| BINDING | 20 | 20 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[ILVM] | ||||||||
| BINDING | 45 | 45 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
| BINDING | 66 | 66 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
E | ||||||||
| BINDING | 91 | 91 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
| BINDING | 113 | 113 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
N | ||||||||
Additional information
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| Size range | 219-390 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |