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HAMAP rule MF_00607

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General rule information [?]

Accession MF_00607
Dates 9-DEC-2002 (Created)
1-JUN-2023 (Last updated, Version 26)
Name 16SrRNA_methyltr_A
Scope(s) Bacteria
Archaea
Template(s) P06992 (RSMA_ECOLI); P13956 (ERM_BACIU); [ Recover all ]
Triggered by HAMAP; MF_00607 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RSMA
case <OC:Bacteria>
Protein name RecName: Full=Ribosomal RNA small subunit methyltransferase A;
                 EC=2.1.1.182;
AltName: Full=16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase;
AltName: Full=16S rRNA dimethyladenosine transferase;
AltName: Full=16S rRNA dimethylase;
AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase;
else case <OC:Archaea>
Protein name RecName: Full=Probable ribosomal RNA small subunit methyltransferase A;
                 EC=2.1.1.-;
AltName: Full=16S rRNA dimethyladenosine transferase;
AltName: Full=16S rRNA dimethylase;
AltName: Full=S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase;
end case
Gene name Name=rsmA; Synonyms=ksgA;

Comments [?]

case <OC:Bacteria>
FUNCTIONSpecifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
CATALYTIC ACTIVITY Reaction=adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L- methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)- dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:19609, Rhea:RHEA-COMP:10232, Rhea:RHEA-COMP:10233, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74411, ChEBI:CHEBI:74493; EC=2.1.1.182;
else case <OC:Archaea>
FUNCTIONSpecifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0016433; Molecular function:rRNA (adenine) methyltransferase activity
GO:0000154; Biological process:rRNA modification
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00398; RrnaAD; 1;
NCBIfam TIGR00755; KsgA; 1;
PROSITE PS01131; RRNA_A_DIMETH; 1;

Features [?]

From: RSMA_ECOLI (P06992)
Key From To Description Tag Condition FTGroup
BINDING 18 18 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[NH]
BINDING 20 20 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[ILVM]
BINDING 45 45 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
G
BINDING 66 66 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
E
BINDING 91 91 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D
BINDING 113 113 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
N

Additional information [?]

Size range 219-390 amino acids
Related rules None
Fusion Nter: None Cter: None



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