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HAMAP rule MF_00607

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General rule information [?]

Accession MF_00607
Dates 9-DEC-2002 (Created)
1-JUN-2023 (Last updated, Version 26)
Name 16SrRNA_methyltr_A
Scope
Bacteria
Archaea
Templates P06992 (RSMA_ECOLI); P13956 (ERM_BACIU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RSMA
case <OC:Bacteria>
Protein name
RecName: Full=Ribosomal RNA small subunit methyltransferase A;
EC 2.1.1.182;
AltName: Full=16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase;
AltName: Full=16S rRNA dimethyladenosine transferase;
AltName: Full=16S rRNA dimethylase;
AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase;
else case <OC:Archaea>
Protein name
RecName: Full=Probable ribosomal RNA small subunit methyltransferase A;
EC 2.1.1.-;
AltName: Full=16S rRNA dimethyladenosine transferase;
AltName: Full=16S rRNA dimethylase;
AltName: Full=S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase;
end case
Gene name
rsmA, ksgA

Comments [?]

case <OC:Bacteria>
Function Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Catalytic activity RHEA:19609: adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine
EC 2.1.1.182
else case <OC:Archaea>
Function Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.

Keywords [?]

Cytoplasm
Methyltransferase
RNA-binding
rRNA processing
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0016433; Molecular function: rRNA (adenine) methyltransferase activity.
GO:0000154; Biological process: rRNA modification.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00398; RrnaAD; 1;
NCBIfam TIGR00755; KsgA; 1;
PROSITE PS01131; RRNA_A_DIMETH; 1;

Features [?]

From: RSMA_ECOLI (P06992)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     18     18       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [NH]  
BINDING     20     20       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [ILVM]  
BINDING     45     45       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     G  
BINDING     66     66       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     E  
BINDING     91     91       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     D  
BINDING     113     113       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     N  

Additional information [?]

Size range 219-390 amino acids
Related rules None
Fusion None


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