HAMAP rule MF_00617
General rule information
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| Accession | MF_00617 |
| Dates | 7-FEB-2003 (Created)
1-JUN-2023 (Last updated, Version 31) |
| Name | MPGP_rel |
| Scope(s) |
Bacteria Archaea |
| Template(s) | O58690 (MPGP_PYRHO); P76329 (MPGP_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00617 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MPGP |
| Protein name | RecName: Full=Mannosyl-3-phosphoglycerate phosphatase; Short=MPGP; EC=3.1.3.70; |
| case <OC:Archaea> | |
| Gene name | Name=mngB; |
| end case | |
Comments
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| case <OC:Archaea> | |
| FUNCTION | Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG). |
| PATHWAY | Carbohydrate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose (MPG route): step 2/2. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O- (alpha-D-mannosyl)-glycerate + phosphate; Xref=Rhea:RHEA:19309, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57541, ChEBI:CHEBI:57744; EC=3.1.3.70; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the HAD-like hydrolase superfamily. MPGP family. |
Keywords
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Gene Ontology
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| GO:0050531; Molecular function:mannosyl-3-phosphoglycerate phosphatase activity |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF08282; Hydrolase_3; 1; |
| NCBIfam | TIGR01484; HAD-SF-IIB; 1; |
| NCBIfam | TIGR01486; HAD-SF-IIB-MPGP; 1; |
| NCBIfam | TIGR02461; osmo_MPG_phos; 0-1; |
| NCBIfam | TIGR02463; MPGP_rel; 0-1; |
Features
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| From: MPGP_PYRHO (O58690) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 8 | 8 | /note="Nucleophile" | D | ||||||||
| BINDING | 8 | 8 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 10 | 10 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 169 | 169 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
S | ||||||||
| BINDING | 204 | 204 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
Additional information
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| Size range | 242-281 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |