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Annotation rule MF_00648
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General rule information [?]

Accession MF_00648
Dates 5-JUN-2003 (Created)
4-SEP-2020 (Last updated, Version 31)
Name Non_canon_purine_NTPase_YjjX
Scope
Bacteria
Archaea
Template P39411 (NCPP_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NCPP
case <OC:Proteobacteria>
Protein name
RecName: Full=Inosine/xanthosine triphosphatase;
Short=ITPase/XTPase;
EC 3.6.1.73;
AltName: Full=Non-canonical purine NTP phosphatase;
AltName: Full=Non-standard purine NTP phosphatase;
AltName: Full=Nucleoside-triphosphate phosphatase;
Short=NTPase;
else
Protein name
RecName: Full=Probable inosine/xanthosine triphosphatase;
Short=ITPase/XTPase;
EC 3.6.1.73;
AltName: Full=Non-canonical purine NTP phosphatase;
AltName: Full=Non-standard purine NTP phosphatase;
AltName: Full=Nucleoside-triphosphate phosphatase;
Short=NTPase;
end case

Comments [?]

Function Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Catalytic activity RHEA:28406: H2O + XTP = H(+) + phosphate + XDP
EC 3.6.1.73
RHEA:28330: H2O + ITP = H(+) + IDP + phosphate
EC 3.6.1.73
Cofactor Mg(2+)
Mn(2+)
Note: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
Subunit Homodimer.
Similarity Belongs to the YjjX NTPase family.

Keywords [?]


Gene Ontology [?]

GO:0017111; Molecular function: nucleoside-triphosphatase activity.

Cross-references [?]

Pfam PF01931; NTPase_I-T; 1;
TIGRFAMs TIGR00258; TIGR00258; 1;

Features [?]

From: NCPP_ECOLI (P39411)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     8     13       Substrate binding     [TS]-[TS]-x-x-x-[K]  
REGION     68     69       Substrate binding     [ED]-[AGV]  
METAL     38     38       Manganese or magnesium     [ED]  
METAL     68     68       Manganese or magnesium     [EQD]  

Additional information [?]

Size range 169-197 amino acids
Related rules None
Fusion Nter: MF_00647 (coaD); Cter: None