HAMAP rule MF_00648

General rule information [?]

Accession	MF_00648
Dates	5-JUN-2003 (Created) 1-JUN-2023 (Last updated, Version 38)

Name	Non_canon_purine_NTPase_YjjX

Scope

Bacteria

Archaea

Template

P39411 (NCPP_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NCPP

case <OC:Pseudomonadota>

Protein name

RecName:		Full=Inosine/xanthosine triphosphatase;
		Short=ITPase/XTPase;
		EC 3.6.1.73;
AltName:		Full=Non-canonical purine NTP phosphatase;
AltName:		Full=Non-standard purine NTP phosphatase;
AltName:		Full=Nucleoside-triphosphate phosphatase;
		Short=NTPase;

else

Protein name

RecName:		Full=Probable inosine/xanthosine triphosphatase;
		Short=ITPase/XTPase;
		EC 3.6.1.73;
AltName:		Full=Non-canonical purine NTP phosphatase;
AltName:		Full=Non-standard purine NTP phosphatase;
AltName:		Full=Nucleoside-triphosphate phosphatase;
		Short=NTPase;

end case

Comments [?]

Function	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Catalytic activity	RHEA:28406: H2O + XTP = H(+) + phosphate + XDP EC 3.6.1.73
	RHEA:28330: H2O + ITP = H(+) + IDP + phosphate EC 3.6.1.73
Cofactor	Mg(2+) Mn(2+) Note: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
Subunit	Homodimer.
Similarity	Belongs to the YjjX NTPase family.

Keywords [?]

Gene Ontology [?]

GO:0017111; Molecular function: ribonucleoside triphosphate phosphatase activity.

Cross-references [?]

Pfam	PF01931; NTPase_I-T; 1;
NCBIfam	TIGR00258; TIGR00258; 1;

Features [?]

From: NCPP_ECOLI (P39411)

Key From To Description Tag Condition FTGroup

BINDING 8 13 /ligand="substrate [TS]-[TS]-x-x-x-[K]

BINDING 68 69 /ligand="substrate [ED]-[AGV]

BINDING 38 38 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 [ED]

BINDING 68 68 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 [EQD]

Additional information [?]