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HAMAP rule MF_00648

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General rule information [?]

Accession MF_00648
Dates 5-JUN-2003 (Created)
1-JUN-2023 (Last updated, Version 38)
Name Non_canon_purine_NTPase_YjjX
Scope(s) Bacteria
Archaea
Template(s) P39411 (NCPP_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00648 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NCPP
case <OC:Pseudomonadota>
Protein name RecName: Full=Inosine/xanthosine triphosphatase;
                 Short=ITPase/XTPase;
                 EC=3.6.1.73;
AltName: Full=Non-canonical purine NTP phosphatase;
AltName: Full=Non-standard purine NTP phosphatase;
AltName: Full=Nucleoside-triphosphate phosphatase;
                 Short=NTPase;
else
Protein name RecName: Full=Probable inosine/xanthosine triphosphatase;
                 Short=ITPase/XTPase;
                 EC=3.6.1.73;
AltName: Full=Non-canonical purine NTP phosphatase;
AltName: Full=Non-standard purine NTP phosphatase;
AltName: Full=Nucleoside-triphosphate phosphatase;
                 Short=NTPase;
end case

Comments [?]

FUNCTIONPhosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
CATALYTIC ACTIVITY Reaction=H2O + XTP = H(+) + phosphate + XDP; Xref=Rhea:RHEA:28406, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:59884, ChEBI:CHEBI:61314; EC=3.6.1.73;
CATALYTIC ACTIVITY Reaction=H2O + ITP = H(+) + IDP + phosphate; Xref=Rhea:RHEA:28330, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58280, ChEBI:CHEBI:61402; EC=3.6.1.73;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).;
SUBUNITHomodimer.
SIMILARITYBelongs to the YjjX NTPase family.

Keywords [?]


Gene Ontology [?]

GO:0017111; Molecular function:ribonucleoside triphosphate phosphatase activity

Cross-references [?]

Pfam PF01931; NTPase_I-T; 1;
NCBIfam TIGR00258; TIGR00258; 1;

Features [?]

From: NCPP_ECOLI (P39411)
Key From To Description Tag Condition FTGroup
BINDING 8 13 /ligand="substrate" [TS]-[TS]-x-x-x-[K]
BINDING 68 69 /ligand="substrate" [ED]-[AGV]
BINDING 38 38 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
[ED]
BINDING 68 68 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
[EQD]

Additional information [?]

Size range 169-197 amino acids
Related rules None
Fusion Nter: MF_00647 (coaD) Cter: None



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