HAMAP rule MF_00648
General rule information
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| Accession | MF_00648 |
| Dates | 5-JUN-2003 (Created)
2-SEP-2024 (Last updated, Version 39) |
| Name | Non_canon_purine_NTPase_YjjX |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P39411 (NCPP_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00648 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NCPP |
| case <OC:Pseudomonadota> | |
| Protein name | RecName: Full=Inosine/xanthosine triphosphatase; Short=ITPase/XTPase; EC=3.6.1.73; AltName: Full=Non-canonical purine NTP phosphatase; AltName: Full=Non-standard purine NTP phosphatase; AltName: Full=Nucleoside-triphosphate phosphatase; Short=NTPase; |
| else | |
| Protein name | RecName: Full=Probable inosine/xanthosine triphosphatase; Short=ITPase/XTPase; EC=3.6.1.73; AltName: Full=Non-canonical purine NTP phosphatase; AltName: Full=Non-standard purine NTP phosphatase; AltName: Full=Nucleoside-triphosphate phosphatase; Short=NTPase; |
| end case | |
Comments
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| FUNCTION | Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. |
| CATALYTIC ACTIVITY | Reaction=XTP + H2O = XDP + phosphate + H(+); Xref=Rhea:RHEA:28406, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:59884, ChEBI:CHEBI:61314; EC=3.6.1.73; |
| CATALYTIC ACTIVITY | Reaction=ITP + H2O = IDP + phosphate + H(+); Xref=Rhea:RHEA:28330, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58280, ChEBI:CHEBI:61402; EC=3.6.1.73; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).; |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the YjjX NTPase family. |
Keywords
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Gene Ontology
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| GO:0017111; Molecular function:ribonucleoside triphosphate phosphatase activity |
Cross-references
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Features
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| From: NCPP_ECOLI (P39411) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 8 | 13 | /ligand="substrate" | [TS]-[TS]-x-x-x-[K] | ||||||||
| BINDING | 68 | 69 | /ligand="substrate" | [ED]-[AGV] | ||||||||
| BINDING | 38 | 38 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
[ED] | ||||||||
| BINDING | 68 | 68 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
[EQD] | ||||||||
Additional information
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| Size range | 169-197 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_00647 (coaD) Cter: None |