HAMAP rule MF_00733
General rule information
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| Accession | MF_00733 |
| Dates | 24-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 22) |
| Name | RocA |
| Scope(s) |
Bacteria Bacillales |
| Template(s) | P39634 (ROCA_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00733 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ROCA |
| Protein name | RecName: Full=1-pyrroline-5-carboxylate dehydrogenase; Short=P5C dehydrogenase; EC=1.2.1.88; AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase; |
| Gene name | Name=rocA; |
Comments
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| CATALYTIC ACTIVITY | Reaction=H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L- glutamate + NADH; Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58066; EC=1.2.1.88; |
| PATHWAY | Amino-acid degradation; L-proline degradation into L- glutamate; L-glutamate from L-proline: step 2/2. |
| SIMILARITY | Belongs to the aldehyde dehydrogenase family. RocA subfamily. |
Keywords
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Gene Ontology
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| GO:0003842; Molecular function:1-pyrroline-5-carboxylate dehydrogenase activity |
| GO:0006537; Biological process:glutamate biosynthetic process |
Cross-references
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| Pfam | PF00171; Aldedh; 1; |
| NCBIfam | TIGR01237; D1pyr5carbox2; 1; |
| PROSITE | PS00070; ALDEHYDE_DEHYDR_CYS; 1; |
| PROSITE | PS00687; ALDEHYDE_DEHYDR_GLU; 1; |
Features
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| From: ROCA_BACSU (P39634) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 286 | 286 | E | |||||||||
| ACT_SITE | 320 | 320 | C | |||||||||
Additional information
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| Size range | 514-515 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |