HAMAP rule MF_00737

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00737
Accession	MF_00737
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 26)
Name	Formimidoylglutam
Scope(s)	Bacteria Archaea Halobacteria
Template(s)	P42068; [ Recover all ]
Triggered by	HAMAP; MF_00737 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OS:Pseudomonas>
Identifier	HUTGL
else
Identifier	HUTG
end case
Protein name	RecName: Full=Formimidoylglutamase; EC=3.5.3.8; AltName: Full=Formiminoglutamase; AltName: Full=Formiminoglutamate hydrolase;
case not <OS:Pseudomonas>
Gene name	Name=hutG;
end case

Comments [?]

FUNCTION	Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide.
CATALYTIC ACTIVITY	Reaction=N-formimidoyl-L-glutamate + H2O = formamide + L-glutamate; Xref=Rhea:RHEA:22492, ChEBI:CHEBI:15377, ChEBI:CHEBI:16397, ChEBI:CHEBI:29985, ChEBI:CHEBI:58928; EC=3.5.3.8;
COFACTOR	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
PATHWAY	Amino-acid degradation; L-histidine degradation into L- glutamate; L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1.
SIMILARITY	Belongs to the arginase family.

Keywords [?]

Gene Ontology [?]

GO:0050415; Molecular function:formimidoylglutamase activity

GO:0030145; Molecular function:manganese ion binding

GO:0006548; Biological process:L-histidine catabolic process

Cross-references [?]

Features [?]

From: HUTG_BACSU (P42068)
Key	From	To	Description	Tag	Condition	FTGroup
BINDING	127	127	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1"		[HN]	1
BINDING	150	150	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1"		D	1
BINDING	150	150	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2"		D	1
BINDING	152	152	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2"		H	1
BINDING	154	154	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1"		D	1
BINDING	242	242	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1"		[DC]	1
BINDING	242	242	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2"		[DC]	1
BINDING	244	244	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2"		D	1

Additional information [?]