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HAMAP rule MF_00737

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General rule information [?]

Accession MF_00737
Dates 25-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 25)
Name Formimidoylglutam
Scope(s) Bacteria
Archaea
Halobacteria
Template(s) P42068 (HUTG_BACSU); [ Recover all ]
Triggered by HAMAP; MF_00737 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OS:Pseudomonas>
Identifier HUTGL
else
Identifier HUTG
end case
Protein name RecName: Full=Formimidoylglutamase;
                 EC=3.5.3.8;
AltName: Full=Formiminoglutamase;
AltName: Full=Formiminoglutamate hydrolase;
case not <OS:Pseudomonas>
Gene name Name=hutG;
end case

Comments [?]

FUNCTIONCatalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide.
CATALYTIC ACTIVITY Reaction=H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate; Xref=Rhea:RHEA:22492, ChEBI:CHEBI:15377, ChEBI:CHEBI:16397, ChEBI:CHEBI:29985, ChEBI:CHEBI:58928; EC=3.5.3.8;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
PATHWAYAmino-acid degradation; L-histidine degradation into L- glutamate; L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1.
SIMILARITYBelongs to the arginase family.

Keywords [?]


Gene Ontology [?]

GO:0050415; Molecular function:formimidoylglutamase activity
GO:0030145; Molecular function:manganese ion binding
GO:0006548; Biological process:histidine catabolic process

Cross-references [?]

Pfam PF00491; Arginase; 1;
PIRSF PIRSF036979; Arginase; 1;
PRINTS PR00116; ARGINASE; 1;
NCBIfam TIGR01227; hutG; 1;
PROSITE PS01053; ARGINASE_1; 1;
PROSITE PS51409; ARGINASE_2; 1;

Features [?]

From: HUTG_BACSU (P42068)
Key From To Description Tag Condition FTGroup
BINDING 127 127 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"
[HN] 1
BINDING 150 150 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"
D 1
BINDING 150 150 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"
D 1
BINDING 152 152 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"
H 1
BINDING 154 154 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"
D 1
BINDING 242 242 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"
[DC] 1
BINDING 242 242 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"
[DC] 1
BINDING 244 244 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"
D 1

Additional information [?]

Size range 306-364 amino acids
Related rules None
Fusion Nter: None Cter: None



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