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Annotation rule MF_00737
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General rule information [?]

Accession MF_00737
Dates 25-NOV-2003 (Created)
18-NOV-2019 (Last updated, Version 21)
Name Formimidoylglutam
Scope
Bacteria
Archaea; Halobacteria
Template P42068 (HUTG_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HUTG
Protein name
RecName: Full=Formimidoylglutamase;
EC 3.5.3.8;
AltName: Full=Formiminoglutamase;
AltName: Full=Formiminoglutamate hydrolase;
Gene name
hutG

Comments [?]

Function Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
Catalytic activity RHEA:22492: H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate
EC 3.5.3.8
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
Pathway Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1.
Similarity Belongs to the arginase family.

Keywords [?]

Hydrolase
Histidine metabolism
case <FTGroup:1>
Metal-binding
Manganese
end case

Gene Ontology [?]

GO:0050415; Molecular function: formimidoylglutamase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0006548; Biological process: histidine catabolic process.

Cross-references [?]

Pfam PF00491; Arginase; 1;
PIRSF PIRSF036979; Arginase; 1;
PRINTS PR00116; ARGINASE; 1;
TIGRFAMs TIGR01227; hutG; 1;
PROSITE PS01053; ARGINASE_1; 1;
PS51409; ARGINASE_2; 1;

Features [?]

From: HUTG_BACSU (P42068)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     127     127       Manganese 1     [HN]   1
METAL     150     150       Manganese 1     D   1
METAL     150     150       Manganese 2     D   1
METAL     152     152       Manganese 2     H   1
METAL     154     154       Manganese 1     D   1
METAL     242     242       Manganese 1     [DC]   1
METAL     242     242       Manganese 2     [DC]   1
METAL     244     244       Manganese 2     D   1

Additional information [?]

Size range 306-364 amino acids
Related rules None
Fusion None


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