HAMAP rule MF_00737

General rule information [?]

Accession	MF_00737
Dates	25-NOV-2003 (Created) 19-NOV-2022 (Last updated, Version 24)

Name	Formimidoylglutam

Scope

Bacteria

Archaea; Halobacteria

Template

P42068 (HUTG_BACSU)

Triggered by

HAMAP; MF_00737 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OS:Pseudomonas>

Identifier

HUTGL

else

Identifier

HUTG

end case

Protein name

RecName:		Full=Formimidoylglutamase;
		EC 3.5.3.8;
AltName:		Full=Formiminoglutamase;
AltName:		Full=Formiminoglutamate hydrolase;

case not <OS:Pseudomonas>

Gene name

hutG

end case

Comments [?]

Function	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
Catalytic activity	RHEA:22492: H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate EC 3.5.3.8
Cofactor	Mn(2+) Note: Binds 2 manganese ions per subunit.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (hydrolase route): step 1/1.
Similarity	Belongs to the arginase family.

Keywords [?]

Hydrolase
Histidine metabolism

case <FTGroup:1>

Metal-binding
Manganese

end case

Gene Ontology [?]

GO:0050415; Molecular function: formimidoylglutamase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0006548; Biological process: histidine catabolic process.

Cross-references [?]

Pfam	PF00491; Arginase; 1;
PIRSF	PIRSF036979; Arginase; 1;
PRINTS	PR00116; ARGINASE; 1;
TIGRFAMs	TIGR01227; hutG; 1;
PROSITE	PS01053; ARGINASE_1; 1;
	PS51409; ARGINASE_2; 1;

Features [?]

From: HUTG_BACSU (P42068)

Key From To Description Tag Condition FTGroup

BINDING 127 127 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 [HN] 1

BINDING 150 150 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 D 1

BINDING 150 150 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 D 1

BINDING 152 152 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 H 1

BINDING 154 154 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 D 1

BINDING 242 242 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1 [DC] 1

BINDING 242 242 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 [DC] 1

BINDING 244 244 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2 D 1

Additional information [?]

Size range	306-364 amino acids
Related rules	None
Fusion	None

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