Home  |  Contact
Annotation rule MF_00750
Send feedback

General rule information [?]

Accession MF_00750
Dates 23-JAN-2004 (Created)
4-MAY-2020 (Last updated, Version 26)
Name Choline_dehydrogen
Scope
Bacteria; Firmicutes
Bacteria; Proteobacteria
Template P17444 (BETA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
BETA
Protein name
RecName: Full=Oxygen-dependent choline dehydrogenase;
Short=CDH;
Short=CHD;
EC 1.1.99.1;
AltName: Full=Betaine aldehyde dehydrogenase;
Short=BADH;
EC 1.2.1.8;
Gene name
betA

Comments [?]

Function Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
Catalytic activity RHEA:17433: A + choline = AH2 + betaine aldehyde
EC 1.1.99.1
RHEA:15305: betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH
EC 1.2.1.8
Cofactor FAD
Pathway Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Similarity Belongs to the GMC oxidoreductase family.

Keywords [?]


Gene Ontology [?]

GO:0008812; Molecular function: choline dehydrogenase activity.
GO:0019285; Biological process: glycine betaine biosynthetic process from choline.

Cross-references [?]

Pfam PF05199; GMC_oxred_C; 1;
PF00732; GMC_oxred_N; 1;
TIGRFAMs TIGR01810; BetA; 1;
PROSITE PS00623; GMC_OXRED_1; 1;
PS00624; GMC_OXRED_2; 1;

Features [?]

From: BETA_ECOLI (P17444)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     4     33       FAD        
ACT_SITE     473     473       Proton acceptor     H  

Additional information [?]

Size range 549-572 amino acids
Related rules None
Fusion None