HAMAP rule MF_00750
General rule information
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| Accession | MF_00750 |
| Dates | 23-JAN-2004 (Created)
1-JUN-2023 (Last updated, Version 31) |
| Name | Choline_dehydrogen |
| Scope(s) |
Bacteria Bacillota Pseudomonadota |
| Template(s) | P17444 (BETA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00750 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | BETA |
| Protein name | RecName: Full=Oxygen-dependent choline dehydrogenase; Short=CDH; Short=CHD; EC=1.1.99.1; AltName: Full=Betaine aldehyde dehydrogenase; Short=BADH; EC=1.2.1.8; |
| Gene name | Name=betA; |
Comments
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| FUNCTION | Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. |
| CATALYTIC ACTIVITY | Reaction=A + choline = AH2 + betaine aldehyde; Xref=Rhea:RHEA:17433, ChEBI:CHEBI:13193, ChEBI:CHEBI:15354, ChEBI:CHEBI:15710, ChEBI:CHEBI:17499; EC=1.1.99.1; |
| CATALYTIC ACTIVITY | Reaction=betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH; Xref=Rhea:RHEA:15305, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15710, ChEBI:CHEBI:17750, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.8; |
| COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
| PATHWAY | Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. |
| SIMILARITY | Belongs to the GMC oxidoreductase family. |
Keywords
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Gene Ontology
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| GO:0008812; Molecular function:choline dehydrogenase activity |
| GO:0019285; Biological process:glycine betaine biosynthetic process from choline |
Cross-references
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| Pfam | PF05199; GMC_oxred_C; 1; |
| Pfam | PF00732; GMC_oxred_N; 1; |
| NCBIfam | TIGR01810; BetA; 1; |
| PROSITE | PS00623; GMC_OXRED_1; 1; |
| PROSITE | PS00624; GMC_OXRED_2; 1; |
Features
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| From: BETA_ECOLI (P17444) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 4 | 33 | /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692" |
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| ACT_SITE | 473 | 473 | /note="Proton acceptor" | H | ||||||||
Additional information
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| Size range | 549-572 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |