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HAMAP rule MF_00750

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General rule information [?]

Accession MF_00750
Dates 23-JAN-2004 (Created)
1-JUN-2023 (Last updated, Version 31)
Name Choline_dehydrogen
Scope(s) Bacteria
Bacillota
Pseudomonadota
Template(s) P17444 (BETA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00750 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BETA
Protein name RecName: Full=Oxygen-dependent choline dehydrogenase;
                 Short=CDH;
                 Short=CHD;
                 EC=1.1.99.1;
AltName: Full=Betaine aldehyde dehydrogenase;
                 Short=BADH;
                 EC=1.2.1.8;
Gene name Name=betA;

Comments [?]

FUNCTIONInvolved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
CATALYTIC ACTIVITY Reaction=A + choline = AH2 + betaine aldehyde; Xref=Rhea:RHEA:17433, ChEBI:CHEBI:13193, ChEBI:CHEBI:15354, ChEBI:CHEBI:15710, ChEBI:CHEBI:17499; EC=1.1.99.1;
CATALYTIC ACTIVITY Reaction=betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH; Xref=Rhea:RHEA:15305, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15710, ChEBI:CHEBI:17750, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.8;
COFACTOR Name=FAD; Xref=ChEBI:CHEBI:57692;
PATHWAYAmine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
SIMILARITYBelongs to the GMC oxidoreductase family.

Keywords [?]


Gene Ontology [?]

GO:0008812; Molecular function:choline dehydrogenase activity
GO:0019285; Biological process:glycine betaine biosynthetic process from choline

Cross-references [?]

Pfam PF05199; GMC_oxred_C; 1;
Pfam PF00732; GMC_oxred_N; 1;
NCBIfam TIGR01810; BetA; 1;
PROSITE PS00623; GMC_OXRED_1; 1;
PROSITE PS00624; GMC_OXRED_2; 1;

Features [?]

From: BETA_ECOLI (P17444)
Key From To Description Tag Condition FTGroup
BINDING 4 33 /ligand="FAD"
/ligand_id="ChEBI:CHEBI:57692"
ACT_SITE 473 473 /note="Proton acceptor" H

Additional information [?]

Size range 549-572 amino acids
Related rules None
Fusion Nter: None Cter: None



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