HAMAP rule MF_00750

General rule information [?]

Accession	MF_00750
Dates	23-JAN-2004 (Created) 1-JUN-2023 (Last updated, Version 31)

Name	Choline_dehydrogen

Scope

Bacteria; Bacillota

Bacteria; Pseudomonadota

Template

P17444 (BETA_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

BETA

Protein name

RecName:		Full=Oxygen-dependent choline dehydrogenase;
		Short=CDH;
		Short=CHD;
		EC 1.1.99.1;
AltName:		Full=Betaine aldehyde dehydrogenase;
		Short=BADH;
		EC 1.2.1.8;

Gene name

betA

Comments [?]

Function	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
Catalytic activity	RHEA:17433: A + choline = AH2 + betaine aldehyde EC 1.1.99.1
	RHEA:15305: betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH EC 1.2.1.8
Cofactor	FAD
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Similarity	Belongs to the GMC oxidoreductase family.

Keywords [?]

Gene Ontology [?]

GO:0008812; Molecular function: choline dehydrogenase activity.
GO:0019285; Biological process: glycine betaine biosynthetic process from choline.

Cross-references [?]

Features [?]

From: BETA_ECOLI (P17444)

Key From To Description Tag Condition FTGroup

BINDING 4 33 /ligand="FAD" /ligand_id="ChEBI:CHEBI:57692

ACT_SITE 473 473 Proton acceptor H

Additional information [?]