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Annotation rule MF_00812
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General rule information [?]

Accession MF_00812
Dates 22-AUG-2005 (Created)
18-NOV-2019 (Last updated, Version 20)
Name Thiopur_methtran
Scope
Bacteria; Proteobacteria
Template O86262 (TPMT_PSESJ)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TPMT
Protein name
RecName: Full=Thiopurine S-methyltransferase;
EC 2.1.1.67;
AltName: Full=Thiopurine methyltransferase;
Gene name
tpm

Comments [?]

Catalytic activity Reaction=S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.; EC=2.1.1.67;
Subcellular location Cytoplasm.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

Keywords [?]

Cytoplasm
Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0008119; Molecular function: thiopurine S-methyltransferase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF05724; TPMT; 1;
PIRSF PIRSF023956; Thiopurine_S-methyltransferase; 1;
TIGRFAMs TIGR03840; TMPT_Se_Te; 1;
PROSITE PS51585; SAM_MT_TPMT; 1;

Features [?]

From: TPMT_VIBCH (Q9KSN0)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     11     11       S-adenosyl-L-methionine     W  
BINDING     46     46       S-adenosyl-L-methionine; via carbonyl oxygen     [LM]  
BINDING     67     67       S-adenosyl-L-methionine     E  
BINDING     122     122       S-adenosyl-L-methionine     R  

Additional information [?]

Size range 213-235 amino acids
Related rules None
Fusion None


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