HAMAP rule MF_00812
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00812 |
| Accession | MF_00812 |
| Dates | 22-AUG-2005 (Created)
01-JUN-2023 (Last updated, Version 25) |
| Name | Thiopur_methtran |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | O86262; [ Recover all ] |
| Triggered by |
HAMAP; MF_00812 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TPMT |
| Protein name | RecName: Full=Thiopurine S-methyltransferase; EC=2.1.1.67; AltName: Full=Thiopurine methyltransferase; |
| Gene name | Name=tpm; |
Comments
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| CATALYTIC ACTIVITY | Reaction=S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L- homocysteine + a thiopurine S-methylether.; EC=2.1.1.67; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. |
Keywords
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Gene Ontology
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| GO:0008119; Molecular function:thiopurine S-methyltransferase activity |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF05724; TPMT; 1; |
| PIRSF | PIRSF023956; Thiopurine_S-methyltransferase; 1; |
| NCBIfam | TIGR03840; TMPT_Se_Te; 1; |
| PROSITE | PS51585; SAM_MT_TPMT; 1; |
Features
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| From: TPMT_VIBCH (Q9KSN0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 11 | 11 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
W | ||||||||
| BINDING | 46 | 46 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[LM] | ||||||||
| BINDING | 67 | 67 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
E | ||||||||
| BINDING | 122 | 122 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
R | ||||||||
Additional information
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| Size range | 213-235 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |