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HAMAP rule MF_00812

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General rule information [?]

Accession MF_00812
Dates 22-AUG-2005 (Created)
1-JUN-2023 (Last updated, Version 24)
Name Thiopur_methtran
Scope(s) Bacteria
Pseudomonadota
Template(s) O86262 (TPMT_PSESJ); [ Recover all ]
Triggered by HAMAP; MF_00812 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TPMT
Protein name RecName: Full=Thiopurine S-methyltransferase;
                 EC=2.1.1.67;
AltName: Full=Thiopurine methyltransferase;
Gene name Name=tpm;

Comments [?]

CATALYTIC ACTIVITY Reaction=S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L- homocysteine + a thiopurine S-methylether.; EC=2.1.1.67;
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

Keywords [?]


Gene Ontology [?]

GO:0008119; Molecular function:thiopurine S-methyltransferase activity
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF05724; TPMT; 1;
PIRSF PIRSF023956; Thiopurine_S-methyltransferase; 1;
NCBIfam TIGR03840; TMPT_Se_Te; 1;
PROSITE PS51585; SAM_MT_TPMT; 1;

Features [?]

From: TPMT_VIBCH (Q9KSN0)
Key From To Description Tag Condition FTGroup
BINDING 11 11 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
W
BINDING 46 46 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[LM]
BINDING 67 67 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
E
BINDING 122 122 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
R

Additional information [?]

Size range 213-235 amino acids
Related rules None
Fusion Nter: None Cter: None



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