HAMAP rule MF_00812
General rule information
[?]
Accession |
MF_00812 |
Dates |
22-AUG-2005 (Created) 1-JUN-2023 (Last updated, Version 24) |
Scope |
Bacteria; Pseudomonadota |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Thiopurine S-methyltransferase;
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EC 2.1.1.67;
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AltName:
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Full=Thiopurine methyltransferase;
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Catalytic activity |
Reaction=S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.; EC=2.1.1.67; |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. |
GO:0008119; Molecular function: thiopurine S-methyltransferase activity.
GO:0005737; Cellular component: cytoplasm.
From: TPMT_VIBCH (Q9KSN0) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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11
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11
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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W
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BINDING
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46
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46
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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[LM]
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BINDING
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67
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67
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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E
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BINDING
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122
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122
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/ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789
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R
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Additional information
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Size range |
213-235 amino acids |
Related rules |
None |
Fusion |
None |