HAMAP rule MF_00812

General rule information [?]

Accession	MF_00812
Dates	22-AUG-2005 (Created) 1-JUN-2023 (Last updated, Version 24)

Name	Thiopur_methtran

Scope

Bacteria; Pseudomonadota

Template

O86262 (TPMT_PSESJ)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TPMT

Protein name

RecName:		Full=Thiopurine S-methyltransferase;
		EC 2.1.1.67;
AltName:		Full=Thiopurine methyltransferase;

Gene name

tpm

Comments [?]

Catalytic activity	Reaction=S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.; EC=2.1.1.67;
Subcellular location	Cytoplasm.
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

Keywords [?]

Gene Ontology [?]

GO:0008119; Molecular function: thiopurine S-methyltransferase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF05724; TPMT; 1;
PIRSF	PIRSF023956; Thiopurine_S-methyltransferase; 1;
NCBIfam	TIGR03840; TMPT_Se_Te; 1;
PROSITE	PS51585; SAM_MT_TPMT; 1;

Features [?]

From: TPMT_VIBCH (Q9KSN0)

Key From To Description Tag Condition FTGroup

BINDING 11 11 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 W

BINDING 46 46 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [LM]

BINDING 67 67 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 E

BINDING 122 122 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 R

Additional information [?]