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HAMAP rule MF_00869

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General rule information [?]

Accession MF_00869
Dates 6-FEB-2023 (Created)
7-FEB-2023 (Last updated, Version 2)
Name Fusexin-1
Scope(s) Bacteria
Template(s) C0HM55 (FSX1_UNCAX); [ Recover all ]
Triggered by HAMAP; MF_00869 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FSX1
Protein name RecName: Full=Fusexin 1;
Gene name Name=fsx1;

Comments [?]

FUNCTIONExhibits fusogenic activity, mediates cell-cell fusion when present in both cells (bilateral fusion).
SUBUNITHomotrimer stabilized by interdomain contacts and numerous Ca(2+) and Na(+) ions.
SUBCELLULAR LOCATIONCell surface. Cell membrane; multi-pass membrane protein.
DOMAINThe extracellular N-terminus has 4 domains; the first 3 are structurally similar to fusogens from plants, C.elegans and viruses, while the fourth domain is unique to archaea. Domains I and II are discontinuous. The fusion loop in domain II is stabilized by a Ca(2+) ion so that it protrudes from the molecule.
SIMILARITYBelongs to the HAP2/GCS1 family. Fusexin 1 subfamily.

Keywords [?]

Cell membrane
case <FT:2> or <FT:3> or <FT:4> or <FT:5>
Disulfide bond
end case
case <Feature:Signal>
end case
Transmembrane helix

Gene Ontology [?]

GO:0005886; Cellular component:plasma membrane
GO:0045026; Biological process:plasma membrane fusion

Cross-references [?]

Pfam PF10699; HAP2-GCS1; 0-1;
General Signal; -; 0-1;
General Transmembrane; -; 0-5;

Features [?]

From: FSX1_UNCAX (C0HM55)
Key From To Description Tag Condition FTGroup
REGION 143 148 /note="Fusion loop"
DISULFID 125 155 C-x*-C
DISULFID 389 432 C-x*-C
DISULFID 457 477 C-x*-C
DISULFID 490 506 C-x*-C

Additional information [?]

Size range 536-764 amino acids
Related rules None
Fusion Nter: None Cter: None

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