HAMAP rule MF_00869
General rule information
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Accession | MF_00869 |
Dates | 6-FEB-2023 (Created)
7-FEB-2023 (Last updated, Version 2) |
Name | Fusexin-1 |
Scope(s) |
Bacteria Archaea |
Template(s) | C0HM55 (FSX1_UNCAX); [ Recover all ] |
Triggered by |
HAMAP; MF_00869 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | FSX1 |
Protein name | RecName: Full=Fusexin 1; Short=Fsx1; |
Gene name | Name=fsx1; |
Comments
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FUNCTION | Exhibits fusogenic activity, mediates cell-cell fusion when present in both cells (bilateral fusion). |
SUBUNIT | Homotrimer stabilized by interdomain contacts and numerous Ca(2+) and Na(+) ions. |
SUBCELLULAR LOCATION | Cell surface. Cell membrane; multi-pass membrane protein. |
DOMAIN | The extracellular N-terminus has 4 domains; the first 3 are structurally similar to fusogens from plants, C.elegans and viruses, while the fourth domain is unique to archaea. Domains I and II are discontinuous. The fusion loop in domain II is stabilized by a Ca(2+) ion so that it protrudes from the molecule. |
SIMILARITY | Belongs to the HAP2/GCS1 family. Fusexin 1 subfamily. |
Keywords
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Calcium | |
Cell membrane | |
case <FT:2> or <FT:3> or <FT:4> or <FT:5> | |
Disulfide bond | |
end case | |
Membrane | |
Metal-binding | |
case <Feature:Signal> | |
Signal | |
end case | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
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GO:0005886; Cellular component:plasma membrane |
GO:0045026; Biological process:plasma membrane fusion |
Cross-references
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Pfam | PF10699; HAP2-GCS1; 0-1; |
General | Signal; -; 0-1; |
General | Transmembrane; -; 0-5; |
Features
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From: FSX1_UNCAX (C0HM55) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 143 | 148 | /note="Fusion loop" | |||||||||
DISULFID | 125 | 155 | C-x*-C | |||||||||
DISULFID | 389 | 432 | C-x*-C | |||||||||
DISULFID | 457 | 477 | C-x*-C | |||||||||
DISULFID | 490 | 506 | C-x*-C |
Additional information
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Size range | 536-764 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |