HAMAP rule MF_00869
General rule information
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| Accession | MF_00869 |
| Dates | 6-FEB-2023 (Created) 7-FEB-2023 (Last updated, Version 2) |
| Name | Fusexin-1 |
| Scope | Bacteria
Archaea |
| Template | C0HM55 (FSX1_UNCAX) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Exhibits fusogenic activity, mediates cell-cell fusion when present in both cells (bilateral fusion). |
| Subunit | Homotrimer stabilized by interdomain contacts and numerous Ca(2+) and Na(+) ions. |
| Subcellular location | Cell surface. Cell membrane; multi-pass membrane protein. |
| Domain | The extracellular N-terminus has 4 domains; the first 3 are structurally similar to fusogens from plants, C.elegans and viruses, while the fourth domain is unique to archaea. Domains I and II are discontinuous. The fusion loop in domain II is stabilized by a Ca(2+) ion so that it protrudes from the molecule. |
| Similarity | Belongs to the HAP2/GCS1 family. Fusexin 1 subfamily. |
Keywords
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case <FT:2> or <FT:3> or <FT:4> or <FT:5>
end case
case <Feature:Signal>
end case
Gene Ontology
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GO:0005886; Cellular component: plasma membrane.
GO:0045026; Biological process: plasma membrane fusion.
GO:0045026; Biological process: plasma membrane fusion.
Cross-references
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| Pfam | PF10699; HAP2-GCS1; 0-1; |
Computed features
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| General | Signal; -; 0-1; trigger=yes; |
| Transmembrane; -; 0-5; trigger=yes; |
Features
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| From: FSX1_UNCAX (C0HM55) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 143 | 148 | Fusion loop | |||||||||
| DISULFID (Optional) | 125 | 155 | C-x*-C | |||||||||
| DISULFID (Optional) | 389 | 432 | C-x*-C | |||||||||
| DISULFID (Optional) | 457 | 477 | C-x*-C | |||||||||
| DISULFID (Optional) | 490 | 506 | C-x*-C | |||||||||
Additional information
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| Size range | 536-764 amino acids |
| Related rules | None |
| Fusion | None |