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HAMAP rule MF_00869

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General rule information [?]

Accession MF_00869
Dates 6-FEB-2023 (Created)
7-FEB-2023 (Last updated, Version 2)
Name Fusexin-1
Template C0HM55 (FSX1_UNCAX)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Fusexin 1;
Gene name

Comments [?]

Function Exhibits fusogenic activity, mediates cell-cell fusion when present in both cells (bilateral fusion).
Subunit Homotrimer stabilized by interdomain contacts and numerous Ca(2+) and Na(+) ions.
Subcellular location Cell surface. Cell membrane; multi-pass membrane protein.
Domain The extracellular N-terminus has 4 domains; the first 3 are structurally similar to fusogens from plants, C.elegans and viruses, while the fourth domain is unique to archaea. Domains I and II are discontinuous. The fusion loop in domain II is stabilized by a Ca(2+) ion so that it protrudes from the molecule.
Similarity Belongs to the HAP2/GCS1 family. Fusexin 1 subfamily.

Keywords [?]

case <FT:2> or <FT:3> or <FT:4> or <FT:5>
end case
case <Feature:Signal>
end case

Gene Ontology [?]

GO:0005886; Cellular component: plasma membrane.
GO:0045026; Biological process: plasma membrane fusion.

Cross-references [?]

Pfam PF10699; HAP2-GCS1; 0-1;

Computed features [?]

General Signal; -; 0-1; trigger=yes;
Transmembrane; -; 0-5; trigger=yes;

Features [?]

From: FSX1_UNCAX (C0HM55)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     143     148       Fusion loop        
DISULFID (Optional)     125     155             C-x*-C  
DISULFID (Optional)     389     432             C-x*-C  
DISULFID (Optional)     457     477             C-x*-C  
DISULFID (Optional)     490     506             C-x*-C  

Additional information [?]

Size range 536-764 amino acids
Related rules None
Fusion None