HAMAP rule MF_00871

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00871
Accession	MF_00871
Dates	03-SEP-2024 (Created) 04-SEP-2024 (Last updated, Version 3)
Name	RqcP
Scope(s)	Bacteria
Template(s)	P37557; [ Recover all ]
Triggered by	HAMAP; MF_00871 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RQCP
Protein name	RecName: Full=RQC P-site tRNA stabilizing factor; Short=RqcP; AltName: Full=Ribosome-associated protein quality control protein P;
Gene name	Name=rqcP;

Comments [?]

FUNCTION	Key component of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. RqcH recruits Ala-charged tRNA, and with RqcP directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal alanine extensions (Ala tail). The Ala tail promotes nascent chain degradation. RqcP is associated with the translocation-like movement of the peptidyl-tRNA from the A-site into the P-site.
SUBUNIT	Associates with stalled 50S ribosomal subunits. Binds to RqcH, 23S rRNA and the P-site tRNA. Does not require RqcH for association with 50S subunits.
SIMILARITY	Belongs to the RqcP family.

Keywords [?]

Gene Ontology [?]

GO:0019843; Molecular function:rRNA binding

GO:0000049; Molecular function:tRNA binding

GO:0043023; Molecular function:ribosomal large subunit binding

GO:0072344; Biological process:rescue of stalled ribosome

Cross-references [?]

Features [?]

Additional information [?]