HAMAP rule MF_00920
General rule information
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| Accession | MF_00920 |
| Dates | 27-FEB-2012 (Created)
1-JUN-2023 (Last updated, Version 10) |
| Name | FtsY |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P10121 (FTSY_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00920 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FTSY |
| Protein name | RecName: Full=Signal recognition particle receptor FtsY; Short=SRP receptor; EC=3.6.5.4; |
| Gene name | Name=ftsY; |
Comments
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| case <OC:Pseudomonadota> | |
| FUNCTION | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. |
| CATALYTIC ACTIVITY | Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.4; |
| SUBUNIT | Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. |
| else | |
| FUNCTION | Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). |
| CATALYTIC ACTIVITY | Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.4; |
| SUBUNIT | Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. |
| end case | |
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| DOMAIN | Contains an acidic N-terminal A domain, a central N domain and a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains at least two lipid-binding sites. The first site contains the first 14 amino acids (helix 1) and the second binding site is an amphipathic alpha-helix located at the interface between the A- and the N-domain (helix 2). |
| end case | |
| SIMILARITY | Belongs to the GTP-binding SRP family. FtsY subfamily. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Cytoplasm | |
| GTP-binding | |
| Hydrolase | |
| Membrane | |
| Nucleotide-binding | |
| Receptor | |
Gene Ontology
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| GO:0005525; Molecular function:GTP binding |
| GO:0003924; Molecular function:GTPase activity |
| GO:0006612; Biological process:protein targeting to membrane |
| GO:0005737; Cellular component:cytoplasm |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| PROSITE | PS00300; SRP54; 1; |
| Pfam | PF00448; SRP54; 1; |
| Pfam | PF02881; SRP54_N; 1; |
| NCBIfam | TIGR00064; FtsY; 1; |
Features
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| From: FTSY_ECOLI (P10121) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 300 | 307 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
G-x-N-G-x-G-K-T | ||||||||
| BINDING | 382 | 386 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D-[TS]-[AS]-G-R | ||||||||
| BINDING | 446 | 449 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[TS]-K-x-[DE] | ||||||||
Additional information
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| Size range | 288-504 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |