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Annotation rule MF_00920
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General rule information [?]

Accession MF_00920
Dates 27-FEB-2012 (Created)
19-NOV-2019 (Last updated, Version 4)
Name FtsY
Scope
Bacteria
Archaea
Template P10121 (FTSY_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FTSY
Protein name
RecName: Full=Signal recognition particle receptor FtsY;
Short=SRP receptor;
Gene name
ftsY

Comments [?]

case <OC:Proteobacteria>
Function Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
Subunit Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.
else
Function Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Subunit Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm.
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Domain Contains an acidic N-terminal A domain, a central N domain and a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains at least two lipid-binding sites. The first site contains the first 14 amino acids (helix 1) and the second binding site is an amphipathic alpha-helix located at the interface between the A- and the N-domain (helix 2).
end case
Similarity Belongs to the GTP-binding SRP family. FtsY subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0006612; Biological process: protein targeting to membrane.
GO:0005737; Cellular component: cytoplasm.
GO:0031226; Cellular component: intrinsic component of plasma membrane.

Cross-references [?]

PROSITE PS00300; SRP54; 1;
Pfam PF00448; SRP54; 1;
PF02881; SRP54_N; 1;
TIGRFAMs TIGR00064; FtsY; 1;

Features [?]

From: FTSY_ECOLI (P10121)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     300     307       GTP     G-x-N-G-x-G-K-T  
NP_BIND (Optional)     382     386       GTP     D-[TS]-[AS]-G-R  
NP_BIND (Optional)     446     449       GTP     [TS]-K-x-[DE]  

Additional information [?]

Size range 288-504 amino acids
Related rules None
Fusion None