HAMAP rule MF_00938
General rule information
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| Accession | MF_00938 |
| Dates | 23-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 12) |
| Name | ParE_type1 |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P20083 (PARE_ECOLI); Q59961 (PARE_STRPN); [ Recover all ] |
| Triggered by |
HAMAP; MF_00938 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PARE |
| Protein name | RecName: Full=DNA topoisomerase 4 subunit B; EC=5.6.2.2; AltName: Full=Topoisomerase IV subunit B; |
| Gene name | Name=parE; |
Comments
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| FUNCTION | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; |
| SUBUNIT | Heterotetramer composed of ParC and ParE. |
| SIMILARITY | Belongs to the type II topoisomerase family. ParE type 1 subfamily. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0003677; Molecular function:DNA binding |
| GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| GO:0007059; Biological process:chromosome segregation |
| GO:0006265; Biological process:DNA topological change |
Cross-references
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| PROSITE | PS00177; TOPOISOMERASE_II; 1; |
| PROSITE | PS50880; TOPRIM; 1; |
| Pfam | PF00204; DNA_gyraseB; 1; |
| Pfam | PF00986; DNA_gyraseB_C; 1; |
| Pfam | PF02518; HATPase_c; 1; |
| Pfam | PF01751; Toprim; 1; |
| PRINTS | PR00418; TPI2FAMILY; 1; |
| NCBIfam | TIGR01055; parE_Gneg; 1; |
Features
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| From: PARE_ECOLI (P20083) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 110 | 116 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-L-[HN]-G-V-G-x | ||||||||
| BINDING | 5 | 5 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
Y | ||||||||
| BINDING | 42 | 42 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
| BINDING | 69 | 69 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
| BINDING | 334 | 334 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| SITE | 446 | 446 | /note="Interaction with DNA" | N | ||||||||
| SITE | 497 | 497 | /note="Interaction with DNA" | H | ||||||||
| SITE | 615 | 615 | /note="Interaction with DNA" | R | ||||||||
Additional information
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| Size range | 600-750 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | See MF_00939 for ParE type 2 subfamily. |