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Annotation rule MF_00938
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General rule information [?]

Accession MF_00938
Dates 23-JAN-2013 (Created)
7-JUN-2019 (Last updated, Version 6)
Name ParE_type1
Scope
Bacteria; Proteobacteria
Templates P20083 (PARE_ECOLI); Q59961 (PARE_STRPN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PARE
Protein name
RecName: Full=DNA topoisomerase 4 subunit B;
EC=5.6.2.2;
AltName: Full=Topoisomerase IV subunit B;
Gene name
parE

Comments [?]

Function Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2;.
Subunit Heterotetramer composed of ParC and ParE.
Similarity Belongs to the type II topoisomerase family. ParE type 1 subfamily.

Keywords [?]

ATP-binding
DNA-binding
Isomerase
Nucleotide-binding
Topoisomerase

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (ATP-hydrolyzing) activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006265; Biological process: DNA topological change.

Cross-references [?]

PROSITE PS00177; TOPOISOMERASE_II; 1;
PS50880; TOPRIM; 1; trigger=PRU00995;
Pfam PF00204; DNA_gyraseB; 1;
PF00986; DNA_gyraseB_C; 1;
PF02518; HATPase_c; 1;
PF01751; Toprim; 1;
PRINTS PR00418; TPI2FAMILY; 1;
TIGRFAMs TIGR01055; parE_Gneg; 1;

Features [?]

From: PARE_ECOLI (P20083)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     110     116       ATP     G-L-[HN]-G-V-G-x  
BINDING (Optional)     5     5       ATP     Y  
BINDING (Optional)     42     42       ATP     N  
BINDING (Optional)     69     69       ATP     D  
BINDING (Optional)     334     334       ATP     K  
SITE (Optional)     446     446       Interaction with DNA     N  
SITE (Optional)     497     497       Interaction with DNA     H  
SITE (Optional)     615     615       Interaction with DNA     R  

Additional information [?]

Size range 600-750 amino acids
Related rules None
Fusion None
Comments See MF_00939 for ParE type 2 subfamily.


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