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Annotation rule MF_00951
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General rule information [?]

Accession MF_00951
Dates 13-MAR-2013 (Created)
19-NOV-2019 (Last updated, Version 5)
Name RfaH
Scope
Bacteria; Proteobacteria
Template P0AFW0 (RFAH_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RFAH
Protein name
RecName: Full=Transcription antitermination protein RfaH;
Gene name
rfaH

Comments [?]

case <OC:Enterobacterales>
Function Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.
else
Function Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.
end case
Subunit Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).
Similarity Belongs to the RfaH family.

Keywords [?]

DNA-binding
Transcription
Transcription antitermination
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0001073; Molecular function: transcription antitermination factor activity, DNA binding.
GO:0031564; Biological process: transcription antitermination.

Cross-references [?]

Pfam PF02357; NusG; 1;
TIGRFAMs TIGR01955; RfaH; 1;

Additional information [?]

Size range 150-224 amino acids
Related rules None
Fusion None


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