HAMAP rule MF_00951

General rule information [?]

Accession	MF_00951
Dates	13-MAR-2013 (Created) 1-JUN-2023 (Last updated, Version 7)

Name

RfaH

Scope

Bacteria; Pseudomonadota

Template

P0AFW0 (RFAH_ECOLI)

Triggered by

HAMAP; MF_00951 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RFAH

Protein name

RecName:

Full=Transcription antitermination protein RfaH;

Gene name

rfaH

Comments [?]

case <OC:Enterobacterales>

Function

Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.

else

Function

Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.

end case

Subunit	Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).
Similarity	Belongs to the RfaH family.

Keywords [?]

DNA-binding
Transcription
Transcription antitermination
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0001073; Molecular function: transcription antitermination factor activity, DNA binding.
GO:0031564; Biological process: transcription antitermination.

Cross-references [?]

Pfam	PF02357; NusG; 1;
NCBIfam	TIGR01955; RfaH; 1;

Additional information [?]

Size range	150-224 amino acids
Related rules	None
Fusion	None

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