HAMAP rule MF_00951

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00951
Accession	MF_00951
Dates	13-MAR-2013 (Created) 1-JUN-2023 (Last updated, Version 7)
Name	RfaH
Scope(s)	Bacteria Pseudomonadota
Template(s)	P0AFW0 (RFAH_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00951 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RFAH
Protein name	RecName: Full=Transcription antitermination protein RfaH;
Gene name	Name=rfaH;

Comments [?]

case <OC:Enterobacterales>
FUNCTION	Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.
else
FUNCTION	Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components.
end case
SUBUNIT	Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).
SIMILARITY	Belongs to the RfaH family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding

GO:0001073; Molecular function:transcription antitermination factor activity, DNA binding

GO:0031564; Biological process:transcription antitermination

Cross-references [?]

Pfam	PF02357; NusG; 1;
NCBIfam	TIGR01955; RfaH; 1;

Features [?]

Additional information [?]