HAMAP rule MF_00972
General rule information
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Accession | MF_00972 |
Dates | 20-AUG-2013 (Created) 19-NOV-2022 (Last updated, Version 8) |
Name | tRNA_aden_deaminase |
Scope | Bacteria |
Templates | P68398 (TADA_ECOLI); O67050 (TADA_AQUAE); Q5XE14 (TADA_STRP6); A9CK16 (TADA_AGRFC); Q99W51 (TADA_STAAM): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2). |
Catalytic activity | RHEA:43168: adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)
EC 3.5.4.33 |
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Subunit | Homodimer. |
Similarity | Belongs to the cytidine and deoxycytidylate deaminase family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0052717; Molecular function: tRNA-specific adenosine-34 deaminase activity.
GO:0002100; Biological process: tRNA wobble adenosine to inosine editing.
GO:0002100; Biological process: tRNA wobble adenosine to inosine editing.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
Cross-references
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PROSITE | PS00903; CYT_DCMP_DEAMINASES_1; 1; |
PS51747; CYT_DCMP_DEAMINASES_2; 1; trigger=PRU01083; | |
Pfam | PF00383; dCMP_cyt_deam_1; 1; trigger=; |
Features
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From: TADA_ECOLI (P68398) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 59 | 59 | Proton donor | E | ||||||||
BINDING | 57 | 57 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 87 | 87 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | C | 1 | |||||||
BINDING | 90 | 90 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | C | 1 |
Additional information
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Size range | 114-252 amino acids |
Related rules | None |
Fusion | None |