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Annotation rule MF_00972
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General rule information [?]

Accession MF_00972
Dates 20-AUG-2013 (Created)
19-NOV-2019 (Last updated, Version 6)
Name tRNA_aden_deaminase
Scope
Bacteria
Templates P68398 (TADA_ECOLI); O67050 (TADA_AQUAE); Q5XE14 (TADA_STRP6); A9CK16 (TADA_AGRFC); Q99W51 (TADA_STAAM): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TADA
Protein name
RecName: Full=tRNA-specific adenosine deaminase;
EC 3.5.4.33;
Gene name
tadA

Comments [?]

Function Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Catalytic activity RHEA:43168: adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)
EC 3.5.4.33
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Subunit Homodimer.
Similarity Belongs to the cytidine and deoxycytidylate deaminase family.

Keywords [?]

Hydrolase
tRNA processing
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0052717; Molecular function: tRNA-specific adenosine-34 deaminase activity.
GO:0002100; Biological process: tRNA wobble adenosine to inosine editing.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

PROSITE PS00903; CYT_DCMP_DEAMINASES_1; 1;
PS51747; CYT_DCMP_DEAMINASES_2; 1; trigger=PRU01083;
Pfam PF00383; dCMP_cyt_deam_1; 1; trigger=;

Features [?]

From: TADA_ECOLI (P68398)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     59     59       Proton donor     E  
METAL     57     57       Zinc; via pros nitrogen; catalytic     H   1
METAL     87     87       Zinc; catalytic     C   1
METAL     90     90       Zinc; catalytic     C   1

Additional information [?]

Size range 114-252 amino acids
Related rules None
Fusion None


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