HAMAP rule MF_00972

General rule information [?]

Accession	MF_00972
Dates	20-AUG-2013 (Created) 19-NOV-2022 (Last updated, Version 8)

Name	tRNA_aden_deaminase

Scope

Bacteria

Templates

P68398 (TADA_ECOLI); O67050 (TADA_AQUAE); Q5XE14 (TADA_STRP6); A9CK16 (TADA_AGRFC); Q99W51 (TADA_STAAM): [Recover all]

Triggered by

HAMAP; MF_00972 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TADA

Protein name

RecName:		Full=tRNA-specific adenosine deaminase;
		EC 3.5.4.33;

Gene name

tadA

Comments [?]

Function	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
Catalytic activity	RHEA:43168: adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+) EC 3.5.4.33

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

Subunit	Homodimer.
Similarity	Belongs to the cytidine and deoxycytidylate deaminase family.

Keywords [?]

Hydrolase
tRNA processing

case <FTGroup:1>

Metal-binding
Zinc

end case

Gene Ontology [?]

GO:0052717; Molecular function: tRNA-specific adenosine-34 deaminase activity.
GO:0002100; Biological process: tRNA wobble adenosine to inosine editing.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

Cross-references [?]

PROSITE	PS00903; CYT_DCMP_DEAMINASES_1; 1;
	PS51747; CYT_DCMP_DEAMINASES_2; 1; trigger=PRU01083;
Pfam	PF00383; dCMP_cyt_deam_1; 1; trigger=;

Features [?]

From: TADA_ECOLI (P68398)

Key From To Description Tag Condition FTGroup

ACT_SITE 59 59 Proton donor E

BINDING 57 57 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 87 87 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic C 1

BINDING 90 90 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic C 1

Additional information [?]

Size range	114-252 amino acids
Related rules	None
Fusion	None

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