HAMAP rule MF_00972

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00972
Accession	MF_00972
Dates	20-AUG-2013 (Created) 03-SEP-2024 (Last updated, Version 10)
Name	tRNA_aden_deaminase
Scope(s)	Bacteria
Template(s)	P68398; O67050; Q5XE14; A9CK16; Q99W51; [ Recover all ]
Triggered by	HAMAP; MF_00972 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TADA
Protein name	RecName: Full=tRNA-specific adenosine deaminase; EC=3.5.4.33;
Gene name	Name=tadA;

Comments [?]

FUNCTION	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
CATALYTIC ACTIVITY	Reaction=adenosine(34) in tRNA + H2O + H(+) = inosine(34) in tRNA + NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA- COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
case <FTGroup:1>
COFACTOR	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the cytidine and deoxycytidylate deaminase family.

Keywords [?]

Gene Ontology [?]

GO:0052717; Molecular function:tRNA-specific adenosine-34 deaminase activity
GO:0002100; Biological process:tRNA wobble adenosine to inosine editing
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Features [?]

From: TADA_ECOLI (P68398)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

/note="Proton donor"

BINDING

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

BINDING

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

BINDING

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

Additional information [?]