HAMAP rule MF_01009
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01009 |
| Accession | MF_01009 |
| Dates | 28-FEB-2005 (Created)
21-MAR-2025 (Last updated, Version 22) |
| Name | Thiosulf_sulfurtr |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0A6V5; [ Recover all ] |
| Triggered by |
HAMAP; MF_01009 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GLPE |
| Protein name | RecName: Full=Thiosulfate sulfurtransferase GlpE; EC=2.8.1.1; |
| Gene name | Name=glpE; |
Comments
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| FUNCTION | Transferase that catalyzes the transfer of sulfur from thiosulfate to thiophilic acceptors such as cyanide or dithiols. May function in a CysM-independent thiosulfate assimilation pathway by catalyzing the conversion of thiosulfate to sulfite, which can then be used for L-cysteine biosynthesis. |
| CATALYTIC ACTIVITY | Reaction=thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H(+); Xref=Rhea:RHEA:16881, ChEBI:CHEBI:15378, ChEBI:CHEBI:17359, ChEBI:CHEBI:18022, ChEBI:CHEBI:18407, ChEBI:CHEBI:33542; EC=2.8.1.1; |
| CATALYTIC ACTIVITY | Reaction=thiosulfate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + sulfite + 2 H(+); Xref=Rhea:RHEA:83859, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:17359, ChEBI:CHEBI:29919, ChEBI:CHEBI:29950, ChEBI:CHEBI:33542, ChEBI:CHEBI:50058; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the GlpE family. |
Keywords
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Gene Ontology
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| GO:0004792; Molecular function:thiosulfate-cyanide sulfurtransferase activity |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: GLPE_ECOLI (P0A6V5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 65 | 65 | /note="Cysteine persulfide intermediate" | C | ||||||||
Additional information
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| Size range | 95-140 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |