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Annotation rule MF_01014
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General rule information [?]

Accession MF_01014
Dates 17-APR-2002 (Created)
19-NOV-2019 (Last updated, Version 41)
Name HisA
Scope
Bacteria
Archaea
Templates Q9X0C7 (HIS4_THEMA); P16250 (HIS4_STRCO); P9WMM5 (HIS4_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HIS4
case not <OC:Mycobacteriaceae> and not <OC:Streptomycetaceae>
Protein name
RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
EC 5.3.1.16;
AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
Gene name
hisA
end case
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
Protein name
RecName: Full=Phosphoribosyl isomerase A;
AltName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
EC 5.3.1.16;
AltName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
Short=PRAI;
EC 5.3.1.24;
AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
Gene name
priA, hisA
end case

Comments [?]

case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
Function Involved in both the histidine and tryptophan biosynthetic pathways.
end case
Catalytic activity RHEA:15469: 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
EC 5.3.1.16
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
Catalytic activity RHEA:21540: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
EC 5.3.1.24
end case
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
Pathway Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the HisA/HisF family.

Keywords [?]

case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
end case

Gene Ontology [?]

GO:0003949; Molecular function: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity.
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
GO:0004640; Molecular function: phosphoribosylanthranilate isomerase activity.
end case
GO:0000105; Biological process: histidine biosynthetic process.
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
GO:0000162; Biological process: tryptophan biosynthetic process.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00977; His_biosynth; 1;
TIGRFAMs TIGR00007; TIGR00007; 0-1;
TIGR01919; hisA-trpF; 0-1;

Features [?]

From: HIS4_THEMA (Q9X0C7)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     8     8       Proton acceptor     [DE]  
ACT_SITE     127     127       Proton donor     [DE]  

Additional information [?]

Size range 229-269 amino acids
Related rules MF_01013 (HIS6)
Fusion None