HAMAP rule MF_01014
General rule information
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| Accession | MF_01014 |
| Dates | 17-APR-2002 (Created)
28-JUN-2024 (Last updated, Version 43) |
| Name | HisA |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q9X0C7 (HIS4_THEMA); P16250 (HIS4_STRCO); P9WMM5 (HIS4_MYCTU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01014 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HIS4 |
| case not <OC:Mycobacteriaceae> and not <OC:Streptomycetaceae> | |
| Protein name | RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; EC=5.3.1.16; AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; |
| Gene name | Name=hisA; |
| end case | |
| case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae> | |
| Protein name | RecName: Full=Phosphoribosyl isomerase A; AltName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; EC=5.3.1.16; AltName: Full=N-(5'-phosphoribosyl)anthranilate isomerase; Short=PRAI; EC=5.3.1.24; AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; |
| Gene name | Name=priA; Synonyms=hisA; |
| end case | |
Comments
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| case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae> | |
| FUNCTION | Involved in both the histidine and tryptophan biosynthetic pathways. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D- ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5- phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469, ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16; |
| case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae> | |
| CATALYTIC ACTIVITY | Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2- carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate; Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613; EC=5.3.1.24; |
| end case | |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. |
| case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae> | |
| PATHWAY | Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 3/5. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the HisA/HisF family. |
Keywords
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| Cytoplasm | |
| Isomerase | |
| Amino-acid biosynthesis | |
| Histidine biosynthesis | |
| case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae> | |
| Aromatic amino acid biosynthesis | |
| Tryptophan biosynthesis | |
| end case | |
Gene Ontology
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| GO:0003949; Molecular function:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity | |
| case <OCellular component:Mycobacteriaceae> or <OC:Streptomycetaceae> | |
| GO:0004640; Molecular function:phosphoribosylanthranilate isomerase activity | |
| end case | |
| GO:0000105; Biological process:L-histidine biosynthetic process | |
| case <OCellular component:Mycobacteriaceae> or <OC:Streptomycetaceae> | |
| GO:0000162; Biological process:tryptophan biosynthetic process | |
| end case | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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| Pfam | PF00977; His_biosynth; 1; |
| NCBIfam | TIGR00007; TIGR00007; 0-1; |
| NCBIfam | TIGR01919; hisA-trpF; 0-1; |
Features
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| From: HIS4_THEMA (Q9X0C7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 8 | 8 | /note="Proton acceptor" | [DE] | ||||||||
| ACT_SITE | 127 | 127 | /note="Proton donor" | [DE] | ||||||||
Additional information
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| Size range | 229-269 amino acids |
| Related rules |
MF_01013 |
| Fusion | Nter: None Cter: None |