HAMAP rule MF_01017
General rule information
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| Accession | MF_01017 |
| Dates | 24-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 37) |
| Name | NQOR |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P0A8G6 (NQOR_ECOLI); A1A9Q9 (NQOR_ECOK1); C1I202 (PNPB_PSEWB); [ Recover all ] |
| Triggered by |
HAMAP; MF_01017 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NQOR |
| Protein name | RecName: Full=NAD(P)H dehydrogenase (quinone); EC=1.6.5.2; AltName: Full=NAD(P)H:quinone oxidoreductase; Short=NQO; |
Comments
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| CATALYTIC ACTIVITY | Reaction=a quinone + H(+) + NADH = a quinol + NAD(+); Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2; |
| CATALYTIC ACTIVITY | Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2; |
| COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; Note=Binds 1 FMN per monomer.; |
| SIMILARITY | Belongs to the WrbA family. |
Keywords
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Gene Ontology
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| GO:0003955; Molecular function:NAD(P)H dehydrogenase (quinone) activity |
| GO:0050660; Molecular function:flavin adenine dinucleotide binding |
| GO:0050661; Molecular function:NADP binding |
| GO:0051287; Molecular function:NAD binding |
Cross-references
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| Pfam | PF00258; Flavodoxin_1; 1; |
| NCBIfam | TIGR01755; Flav_wrbA; 1; |
| PROSITE | PS50902; FLAVODOXIN_LIKE; 1; |
Features
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| From: NQOR_ECOLI (P0A8G6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | 4 | 189 | /note="Flavodoxin-like" | |||||||||
| BINDING | 10 | 15 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
S-x-[YWH]-[GA]-[HY]-[ILVMT] | ||||||||
| BINDING | 78 | 80 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
[TA]-R-[FY] | ||||||||
| BINDING | 113 | 118 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
S-[TS]-[GA]-[TS]-x(1,2)-G | ||||||||
| BINDING | 12 | 12 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[YW] | ||||||||
| BINDING | 98 | 98 | /ligand="substrate" | W | ||||||||
| BINDING | 133 | 133 | /ligand="FMN" /ligand_id="ChEBI:CHEBI:58210" |
H | ||||||||
Additional information
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| Size range | 188-230 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |