HAMAP rule MF_01028
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01028 |
| Accession | MF_01028 |
| Dates | 28-FEB-2005 (Created)
03-SEP-2024 (Last updated, Version 23) |
| Name | CimA |
| Scope(s) |
Archaea |
| Template(s) | Q58787; [ Recover all ] |
| Triggered by |
HAMAP; MF_01028 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CIMA |
| Protein name | RecName: Full=Putative (R)-citramalate synthase CimA; EC=2.3.3.21; |
| Gene name | Name=cimA; |
Comments
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| FUNCTION | Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. |
| CATALYTIC ACTIVITY | Reaction=pyruvate + acetyl-CoA + H2O = (3R)-citramalate + CoA + H(+); Xref=Rhea:RHEA:19045, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30934, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.3.21; |
| PATHWAY | Amino-acid biosynthesis; L-isoleucine biosynthesis; 2- oxobutanoate from pyruvate: step 1/3. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the alpha-IPM synthase/homocitrate synthase family. |
Keywords
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Gene Ontology
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| GO:0016747; Molecular function:acyltransferase activity, transferring groups other than amino-acyl groups |
| GO:0009097; Biological process:isoleucine biosynthetic process |
Cross-references
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| Pfam | PF00682; HMGL-like; 1; |
| Pfam | PF08502; LeuA_dimer; 1; |
| NCBIfam | TIGR02090; LEU1_arch; 1; |
| PROSITE | PS00815; AIPM_HOMOCIT_SYNTH_1; 1; |
| PROSITE | PS00816; AIPM_HOMOCIT_SYNTH_2; 1; |
| PROSITE | PS50991; PYR_CT; 1; |
Features
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Additional information
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| Size range | 483-529 amino acids |
| Related rules |
MF_01025 MF_00572 |
| Fusion | Nter: None Cter: None |
| Comments | Difficulty to distinguish between LeuA, CimA and AksA subfamilies. |