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Annotation rule MF_01028
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General rule information [?]

Accession MF_01028
Dates 29-JUL-2002 (Created)
19-NOV-2019 (Last updated, Version 25)
Name CimA
Scope
Archaea
Template Q58787 (CIMA_METJA)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CIMA
Protein name
RecName: Full=Putative (R)-citramalate synthase CimA;
EC 2.3.1.182;
Gene name
cimA

Comments [?]

Function Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
Catalytic activity RHEA:19045: acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)
EC 2.3.1.182
Pathway Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.
Subunit Homodimer.
Similarity Belongs to the alpha-IPM synthase/homocitrate synthase family.

Keywords [?]


Gene Ontology [?]

GO:0016747; Molecular function: transferase activity, transferring acyl groups other than amino-acyl groups.
GO:0009097; Biological process: isoleucine biosynthetic process.

Cross-references [?]

Pfam PF00682; HMGL-like; 1;
PF08502; LeuA_dimer; 1;
TIGRFAMs TIGR02090; LEU1_arch; 1;
PROSITE PS00815; AIPM_HOMOCIT_SYNTH_1; 1;
PS00816; AIPM_HOMOCIT_SYNTH_2; 1;
PS50991; PYR_CT; 1; trigger=PRU01151;

Additional information [?]

Size range 483-529 amino acids
Related rules MF_01025 (LEU1); MF_00572 (LEU1)
Fusion None
Comments Difficulty to distinguish between LeuA, CimA and AksA subfamilies.