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HAMAP rule MF_01049

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General rule information [?]

Accession MF_01049
Dates 13-FEB-2003 (Created)
29-SEP-2022 (Last updated, Version 33)
Name CaiT
Scope
Bacteria; Enterobacterales
Templates P31553 (CAIT_ECOLI); B4EY22 (CAIT_PROMH): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CAIT
Protein name
RecName: Full=L-carnitine/gamma-butyrobetaine antiporter;
Gene name
caiT

Comments [?]

Function Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
Catalytic activity RHEA:29427: (R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)
Pathway Amine and polyamine metabolism; carnitine metabolism.
Subunit Homotrimer.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.

Keywords [?]

Transport
Antiport
Membrane
Transmembrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Transmembrane helix

Gene Ontology [?]

GO:0044667; Molecular function: (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity.
GO:1902603; Biological process: carnitine transmembrane transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02028; BCCT; 1;
TIGRFAMs TIGR00842; bcct; 1;
PROSITE PS01303; BCCT; 1;

Computed features [?]

General Transmembrane; -; 12; trigger=yes;

Additional information [?]

Size range 504-505 amino acids
Related rules None
Fusion None


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