HAMAP rule MF_01049

General rule information [?]

Accession	MF_01049
Dates	13-FEB-2003 (Created) 1-JUN-2023 (Last updated, Version 34)
Name	CaiT
Scope(s)	Bacteria Enterobacterales
Template(s)	P31553 (CAIT_ECOLI); B4EY22 (CAIT_PROMH); [ Recover all ]
Triggered by	HAMAP; MF_01049 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CAIT
Protein name	RecName: Full=L-carnitine/gamma-butyrobetaine antiporter;
Gene name	Name=caiT;

Comments [?]

FUNCTION	Catalyzes the exchange of L-carnitine for gamma- butyrobetaine.
CATALYTIC ACTIVITY	Reaction=(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)- carnitine(in) + 4-(trimethylamino)butanoate(out); Xref=Rhea:RHEA:29427, ChEBI:CHEBI:16244, ChEBI:CHEBI:16347;
PATHWAY	Amine and polyamine metabolism; carnitine metabolism.
SUBUNIT	Homotrimer.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.

Keywords [?]

Transport
Antiport
Membrane
Transmembrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Transmembrane helix

Gene Ontology [?]

GO:0044667; Molecular function:(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity

GO:1902603; Biological process:carnitine transmembrane transport

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]